High incidence of disseminated intravascular coagulation and acute cerebral infarction in acute myeloid leukemia with cup-like nuclei
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- Watanabe Naoki
- Department of Hematology, Juntendo University Shizuoka Hospital, Shizuoka, Japan,
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- Kitahara Hideaki
- Department of Hematology, Juntendo University Shizuoka Hospital, Shizuoka, Japan,
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- Honda Tadahiro
- Department of Hematology, Juntendo University Shizuoka Hospital, Shizuoka, Japan,
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- Iwasaki Hisayo
- Department of Hematology, Juntendo University Shizuoka Hospital, Shizuoka, Japan,
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- Iwao Noriaki
- Department of Hematology, Juntendo University Shizuoka Hospital, Shizuoka, Japan,
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- Komatsu Norio
- Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan
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- Koike Michiaki
- Department of Hematology, Juntendo University Shizuoka Hospital, Shizuoka, Japan,
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Description
<p>In this study, we examined a cohort of Japanese patients with acute myeloid leukemia (AML) with cup-like nuclei. In particular, we attempted to provide a detailed definition of the clinical features of AML with cup-like nuclei. The clinical records of patients diagnosed with de novo AML were collected retrospectively. We showed that approximately 23% of all patients with AML diagnosed during the study period had AML with cup-like nuclei. All three cup-like AML cases had FLT3-ITD mutations. In addition, we reported a high incidence of disseminated intravascular coagulation and acute cerebral infarction in patients with AML with cup-like nuclei. Our results show that AML with cup-like nuclei may be more common than expected. Due to these unique characteristics, recognition of this morphology is recommended.</p>
Journal
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- Journal of Clinical and Experimental Hematopathology
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Journal of Clinical and Experimental Hematopathology 62 (4), 249-252, 2022
The Japanese Society for Lymphoreticular Tissue Research
