{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390014093884110080.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.11249/jsbpjjpp.34.1_7"}}],"dc:title":[{"@language":"en","@value":"Blood metabolome analysis focusing on mental disorders from depression to hikikomori"},{"@language":"ja","@value":"精神疾患の血液メタボローム解析研究：うつ病から社会的ひきこもりまで"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Patients with mental disorders rarely visit psychiatrists from the early stages of illness, which tends to delay the introduction of appropriate medical care. On the other hand, it is not uncommon for these patients to visit non‐psychiatric physicians for their physical symptoms. Therefore, development of biomarkers by blood sampling that can be performed outside of psychiatry will lead to early detection and intervention of mental disorders. With this expectation, we are searching for objective blood biomarkers of mental disorders. \n We herein introduce about blood metabolome analysis and present our recent studies focusing on depression and hikikomori (pathological social withdrawal) . We have found significant associations between depressive severity and 3‐hydroxybutyrate, suicidal ideation and kynurenine metabolites, and hikikomori and acylcarnitine/arginine. Establishment of objective biological evaluation systems for mental disorders is expected to lead to the realization of early detection and intervention of mental disorders as well as to the elimination of prejudice and stigma against mental disorders."},{"@language":"ja","@value":"うつ病など精神疾患をもつ患者が発症初期から精神医療機関を受診することはまれであり，適切な精神医療の導入は遅れがちである。他方，こうした患者は身体症状のために身体科を受診していることがまれではない。しかるに，筆者らは精神科以外でも実施可能な採血による血液バイオマーカーの開発が，精神疾患の早期発見・早期介入につながることを期待して，血液を用いた精神疾患の客観的バイオマーカー開発を進めている。本稿では，血液メタボローム解析について概説し，うつ病やひきこもりに関連した研究の成果を紹介する。筆者らはこれまで抑うつ重症度と3ヒドロキシ酪酸，自殺とキヌレニン経路代謝物，ひきこもりとアシルカルニチン／アルギニンとの関連を萌芽的に見いだしてきた。こうした研究の発展により精神疾患を採血で客観的に生物学的に評価できるシステムが構築されることで，精神疾患の早期発見・早期介入の実現に加えて精神疾患への偏見解消が期待される。"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410014093884110080","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"加藤 隆弘"},{"@language":"en","@value":"Kato Takahiro A"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University"},{"@language":"ja","@value":"九州大学大学院医学研究院精神病態医学"},{"@language":"en","@value":"Mood Disorder/Hikikomori Clinic, Department of Neuropsychiatry, Kyushu University Hospital"},{"@language":"ja","@value":"九州大学病院精神科神経科・気分障害ひきこもり外来"}]},{"@id":"https://cir.nii.ac.jp/crid/1410014093884110082","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Matsushima Toshio"},{"@language":"ja","@value":"松島 敏夫"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学大学院医学研究院精神病態医学"},{"@language":"en","@value":"Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University"},{"@language":"en","@value":"Mood Disorder/Hikikomori Clinic, Department of Neuropsychiatry, Kyushu University Hospital"},{"@language":"ja","@value":"九州大学病院精神科神経科・気分障害ひきこもり外来"}]},{"@id":"https://cir.nii.ac.jp/crid/1410014093884110081","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Setoyama Daiki"},{"@language":"ja","@value":"瀬戸山 大樹"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学病院検査部"},{"@language":"en","@value":"Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Hospital"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"21866465"},{"@type":"PISSN","@value":"21866619"}],"prism:publicationName":[{"@language":"ja","@value":"日本生物学的精神医学会誌"},{"@language":"en","@value":"Japanese Journal of Biological Psychiatry"},{"@language":"ja","@value":"日本生物学的精神医学会誌"},{"@language":"en","@value":"Japanese Journal of Biological Psychiatry"}],"dc:publisher":[{"@language":"en","@value":"Japanese Society of Biological Psychiatry"},{"@language":"ja","@value":"日本生物学的精神医学会"}],"prism:publicationDate":"2023","prism:volume":"34","prism:number":"1","prism:startingPage":"7","prism:endingPage":"12"},"availableAt":"2023","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=metabolome%20analysis","dc:title":"metabolome analysis"},{"@id":"https://cir.nii.ac.jp/all?q=blood%20biomarker","dc:title":"blood biomarker"},{"@id":"https://cir.nii.ac.jp/all?q=depression","dc:title":"depression"},{"@id":"https://cir.nii.ac.jp/all?q=suicide%20prevention","dc:title":"suicide prevention"},{"@id":"https://cir.nii.ac.jp/all?q=hikikomori","dc:title":"hikikomori"},{"@id":"https://cir.nii.ac.jp/all?q=stigma","dc:title":"stigma"}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:2010403822"}]}