Roles of Microglia in Neurodegenerative Diseases

DOI Web Site 1 Citations 63 References Open Access
  • Nakaso Kazuhiro
    Division of Biochemistry, Department of Pathophysiological and Therapeutic Sciences, School of Medicine, Faculty of Medicine, Tottori University, 683-8503 Yonago, Japan

Bibliographic Information

Published
2024
DOI
  • 10.33160/yam.2024.02.001
Publisher
Tottori University Medical Press

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Description

<p>In recent years, microglia have attracted attention owing to their roles in various neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Microglia, which are brain-resident macrophages, not only act as immune cells but also perform other functions in the body. Interestingly, they exert contrasting effects on different neurodegenerative diseases. In addition to the previously reported M1 (toxic) and M2 (protective) types, microglia now also include disease-associated microglia owing to a more elaborate classification. Understanding this detailed classification is necessary to elucidate the association between microglia and neurodegenerative diseases. In this review, we discuss the diverse roles of microglia in neurodegenerative diseases and highlight their potential as therapeutic targets.</p>

Journal

  • Yonago Acta Medica

    Yonago Acta Medica 67 (1), 1-8, 2024

    Tottori University Medical Press

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