{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390017732462127360.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.33160/yam.2024.02.001"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/yam/67/1/67_2024.02.001/_pdf"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2025111472"}}],"dc:title":[{"@language":"en","@value":"Roles of Microglia in Neurodegenerative Diseases"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"<p>In recent years, microglia have attracted attention owing to their roles in                    various neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s                    disease, and amyotrophic lateral sclerosis. Microglia, which are brain-resident                    macrophages, not only act as immune cells but also perform other functions in                    the body. Interestingly, they exert contrasting effects on different                    neurodegenerative diseases. In addition to the previously reported M1 (toxic)                    and M2 (protective) types, microglia now also include disease-associated                    microglia owing to a more elaborate classification. Understanding this detailed                    classification is necessary to elucidate the association between microglia and                    neurodegenerative diseases. In this review, we discuss the diverse roles of                    microglia in neurodegenerative diseases and highlight their potential as                    therapeutic targets.</p>"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410017732462127360","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Nakaso Kazuhiro"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Biochemistry, Department of Pathophysiological and                            Therapeutic Sciences, School of Medicine, Faculty of Medicine, Tottori                            University, 683-8503 Yonago, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"LISSN","@value":"05135710"},{"@type":"EISSN","@value":"13468049"}],"prism:publicationName":[{"@language":"ja","@value":"Yonago Acta Medica"},{"@language":"en","@value":"Yonago Acta Medica"},{"@language":"en","@value":"Yonago Acta Med."}],"dc:publisher":[{"@language":"en","@value":"Tottori University Medical Press"},{"@language":"ja","@value":"ヨナゴ・アクタ・メディカ刊行会"}],"prism:publicationDate":"2024","prism:volume":"67","prism:number":"1","prism:startingPage":"1","prism:endingPage":"8"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://www.jstage.jst.go.jp/article/yam/67/1/67_2024.02.001/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2025111472"}],"availableAt":"2024","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Alzheimer%E2%80%99s%20disease","dc:title":"Alzheimer’s disease"},{"@id":"https://cir.nii.ac.jp/all?q=inflammation","dc:title":"inflammation"},{"@id":"https://cir.nii.ac.jp/all?q=microglia","dc:title":"microglia"},{"@id":"https://cir.nii.ac.jp/all?q=Parkinson%E2%80%99s%20disease","dc:title":"Parkinson’s disease"},{"@id":"https://cir.nii.ac.jp/all?q=therapeutic%20target","dc:title":"therapeutic 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