Alcohol-related upper gastrointestinal diseases encompass a spectrum of conditions, prominently including esophageal squamous cell carcinoma, alongside head and neck cancers such as hypopharyngeal cancer, and gastric cancer. Notably, esophageal squamous cell carcinoma exhibits a strong association with the ethanol content in alcohol and the aldehydes generated during alcohol metabolism. To identify patients at high risk for alcohol-related upper gastrointestinal diseases, it is important to utilize alcohol-related questionnaires and genetic polymorphism association tests targeting alcohol metabolism enzymes. Furthermore, image-enhanced endoscopy is useful for diagnosing hypopharyngeal and esophageal squamous cell carcinomas. Early diagnosis of alcohol-related upper gastrointestinal diseases requires performing endoscopic observations tailored to the patientʼs risk level.
"},{"@language":"ja","@value":"アルコールに関連する上部消化管疾患は，食道扁平上皮癌が代表であるが，下咽頭癌をはじめとする頭頸部癌，さらには胃癌も含まれる．特に食道扁平上皮癌の発癌は，アルコールに含まれるエタノールおよびアルコール代謝中に生じるアルデヒドとの強い関連がある．そのため，高リスク患者の拾い上げには，アルコールに関連する問診票やアルコール代謝関連酵素の遺伝子多型関連検査の活用が重要である．さらに実際の食道扁平上皮癌および下咽頭癌の診断には，画像強調観察を併用した診断が有用であり，患者のリスクに合わせた内視鏡観察を行うことが重要である．
"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410019435379975298","@type":"Researcher","foaf:name":[{"@language":"en","@value":"SASAKI Fumisato"},{"@language":"ja","@value":"佐々木 文郷"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"鹿児島大学大学院 医歯学総合研究科消化器疾患・生活習慣病学"},{"@language":"en","@value":"Digestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences."}]},{"@id":"https://cir.nii.ac.jp/crid/1410019435379975296","@type":"Researcher","foaf:name":[{"@language":"en","@value":"KANMURA Shuji"},{"@language":"ja","@value":"上村 修司"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"鹿児島大学大学院 医歯学総合研究科消化器疾患・生活習慣病学"},{"@language":"en","@value":"Digestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences."}]},{"@id":"https://cir.nii.ac.jp/crid/1410019435379975297","@type":"Researcher","foaf:name":[{"@language":"en","@value":"IDO Akio"},{"@language":"ja","@value":"井戸 章雄"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"鹿児島大学大学院 医歯学総合研究科消化器疾患・生活習慣病学"},{"@language":"en","@value":"Digestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03871207"},{"@type":"LISSN","@value":"03871207"},{"@type":"EISSN","@value":"18845738"}],"prism:publicationName":[{"@language":"ja","@value":"日本消化器内視鏡学会雑誌"},{"@language":"en","@value":"GASTROENTEROLOGICAL ENDOSCOPY"},{"@language":"en","@value":"Gastroenterol. Endosc."},{"@language":"en","@value":"Gastroenterol Endosc"},{"@language":"en","@value":"gastroenterol endosc"},{"@language":"en","@value":"GASTROENTEROL ENDOSC"},{"@language":"ja","@value":"日本消化器内視鏡学会雑誌"},{"@language":"en","@value":"Gastroenterological Endoscopy"}],"dc:publisher":[{"@language":"en","@value":"Japan Gastroenterological Endoscopy Society"},{"@language":"ja","@value":"一般社団法人 日本消化器内視鏡学会"}],"prism:publicationDate":"2024","prism:volume":"66","prism:number":"7","prism:startingPage":"1447","prism:endingPage":"1457"},"url":[{"@id":"https://search.jamas.or.jp/link/ui/2025002357"}],"availableAt":"2024","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E9%A3%9F%E9%81%93%E6%89%81%E5%B9%B3%E4%B8%8A%E7%9A%AE%E7%99%8C","dc:title":"食道扁平上皮癌"},{"@id":"https://cir.nii.ac.jp/all?q=%E4%B8%8B%E5%92%BD%E9%A0%AD%E7%99%8C","dc:title":"下咽頭癌"},{"@id":"https://cir.nii.ac.jp/all?q=%E9%A0%AD%E9%A0%B8%E9%83%A8%E7%99%8C","dc:title":"頭頸部癌"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%83%83%E7%99%8C","dc:title":"胃癌"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%A2%E3%83%AB%E3%82%B3%E3%83%BC%E3%83%AB","dc:title":"アルコール"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%A2%E3%83%AB%E3%82%B3%E3%83%BC%E3%83%AB%E8%84%B1%E6%B0%B4%E7%B4%A0%E9%85%B5%E7%B4%A01B%E5%9E%8B","dc:title":"アルコール脱水素酵素1B型"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%A2%E3%83%AB%E3%83%87%E3%83%92%E3%83%89%E8%84%B1%E6%B0%B4%E7%B4%A0%E9%85%B5%E7%B4%A0%EF%BC%92%E5%9E%8B","dc:title":"アルデヒド脱水素酵素２型"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%A2%E3%82%BB%E3%83%88%E3%82%A2%E3%83%AB%E3%83%87%E3%83%92%E3%83%89","dc:title":"アセトアルデヒド"}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:2013269544"}]}