This is a prospective interventional study to evaluate whether vaginal progesterone（VP）reduces spontaneous preterm birth（sPTB）incidence in pregnant Japanese women with prior spontaneous second-trimester miscarriages（sSTM）or sPTB. The VP group were included singleton pregnancies with prior sSTM or sPTB. VP was administered to the participants between 16+0 and 33+6 weeks of gestation. Maternal background, perinatal outcomes were investigated for eligible patients and compared with the historical control outcomes among participants with singleton pregnancies with prior sSTM or sPTB managed without VP. The main outcome was the incidence of sPTB ＜ 36 weeks of gestation. A total of 79 and 76 pregnancies in the VP and control groups were analyzed. The incidences of prior sSTM and prior sPTB ＜ 28 weeks of gestation were significantly higher in the VP group, and the median earliest gestational ages for prior sSTM and sPTB were significantly earlier in the VP group. The incidence of sPTB ＜ 36 weeks of gestation was lower in the VP group（8.9%）than in the control group（17.1%）. The study findings suggest the possible benefits of VP in reducing the recurrent sPTB.
"},{"@language":"ja","@value":"流早産既往妊婦に対するプロゲステロン腟坐剤（VP）の早産予防効果について検証した前方視介入試験である．VP群の対象は妊娠中期自然流産（sSTM）または自然早産（sPTB）既往のある無症状の単胎妊娠とし，妊娠16+0週～33+6週にVP投与を行った．ヒストリカルコホートを対照群とし，VP投与のないsSTM/sPTB既往のある無症状の単胎妊娠を対象とした．主要評価項目を妊娠36週未満の早産割合とし，両群を比較検討した．VP群は79名，対照群は76名が対象となり，sSTM既往および妊娠28週未満のsPTB既往の割合はVP群で有意に高く，複数回のsSTM/sPTB既往のうち最も早い分娩週数の中央値はVP群が対照群より早かった．妊娠36週未満の早産割合はVP群で8.9%，対照群で17.1%とVP群の方が低かった．流早産既往妊婦へのVP投与は反復早産予防において有用である可能性が示唆された．
"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410020984115941637","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Sato Yuka"},{"@language":"ja","@value":"佐藤 由佳"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University"},{"@language":"ja","@value":"九州大学病院産婦人科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410020984115941760","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"日高 庸博"},{"@language":"en","@value":"Hidaka Nobuhiro"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学病院産婦人科"},{"@language":"en","@value":"Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University"},{"@language":"ja","@value":"福岡市立こども病院産科"},{"@language":"en","@value":"Department of Obstetrics, Fukuoka Children’s Hospital"}]},{"@id":"https://cir.nii.ac.jp/crid/1410020984115941761","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Sakai Atsuhiko"},{"@language":"ja","@value":"坂井 淳彦"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University"},{"@language":"ja","@value":"九州大学病院産婦人科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410020984115941633","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Kido Saki"},{"@language":"ja","@value":"城戸 咲"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学病院産婦人科"},{"@language":"en","@value":"Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410020984115941762","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Fujita Yasuyuki"},{"@language":"ja","@value":"藤田 恭之"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University"},{"@language":"ja","@value":"九州大学病院産婦人科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410020984115941632","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Inoue Hirosuke"},{"@language":"ja","@value":"井上 普介"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学病院小児科"},{"@language":"en","@value":"Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410020984115941635","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Ohga Shouichi"},{"@language":"ja","@value":"大賀 正一"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University"},{"@language":"ja","@value":"九州大学病院小児科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410020984115941636","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Ochiai Masayuki"},{"@language":"ja","@value":"落合 正行"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University"},{"@language":"ja","@value":"九州大学病院小児科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410020984115941634","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Kato Kiyoko"},{"@language":"ja","@value":"加藤 聖子"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University"},{"@language":"ja","@value":"九州大学病院産婦人科"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"1348964X"},{"@type":"EISSN","@value":"24354996"}],"prism:publicationName":[{"@language":"en","@value":"Journal of Japan Society of Perinatal and Neonatal Medicine"},{"@language":"ja","@value":"日本周産期・新生児医学会雑誌"},{"@language":"en","@value":"jjspnm"}],"dc:publisher":[{"@language":"en","@value":"Japan Society of Perinatal and Neonatal Medicine"},{"@language":"ja","@value":"一般社団法人 日本周産期・新生児医学会"}],"prism:publicationDate":"2024","prism:volume":"60","prism:number":"3","prism:startingPage":"429","prism:endingPage":"434"},"url":[{"@id":"https://search.jamas.or.jp/link/ui/2025092857"}],"availableAt":"2024","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=preterm%20birth%20prevention","dc:title":"preterm birth prevention"},{"@id":"https://cir.nii.ac.jp/all?q=prior%20preterm%20birth","dc:title":"prior preterm birth"},{"@id":"https://cir.nii.ac.jp/all?q=vaginal%20progesterone","dc:title":"vaginal progesterone"},{"@id":"https://cir.nii.ac.jp/all?q=preterm%20birth%20prevention","dc:title":"preterm birth prevention"},{"@id":"https://cir.nii.ac.jp/all?q=prior%20preterm%20birth","dc:title":"prior preterm birth"},{"@id":"https://cir.nii.ac.jp/all?q=vaginal%20progesterone","dc:title":"vaginal progesterone"}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:2013588401"}]}