Optimization of inhaled anesthesia for <i>Octodon degus</i> using electroencephalography

DOI 機関リポジトリ 機関リポジトリ 機関リポジトリ (HANDLE) 機関リポジトリ (HANDLE) ほか2件をすべて表示 一部だけ表示 参考文献43件 オープンアクセス
  • Ikai Yuki
    Division of Bio-resources, Department of Biotechnology, Frontier Science Research Center, University of Miyazaki, Kihara 5200, Kiyotake, Miyazaki 889-1692, Japan Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, Kihara 5200, Kiyotake, Miyazaki 889-1692, Japan
  • Nagura-Kato Goro A.
    Division of Bio-resources, Department of Biotechnology, Frontier Science Research Center, University of Miyazaki, Kihara 5200, Kiyotake, Miyazaki 889-1692, Japan
  • Sakamoto Shinsuke H.
    Department of Animal and Grassland Sciences, Faculty of Agriculture, University of Miyazaki, 1-1 Gakuen Kibanadai-nishi, Miyazaki 889-2192, Japan
  • Shinohara Akio
    Division of Bio-resources, Department of Biotechnology, Frontier Science Research Center, University of Miyazaki, Kihara 5200, Kiyotake, Miyazaki 889-1692, Japan
  • Koshimoto Chihiro
    Division of Bio-resources, Department of Biotechnology, Frontier Science Research Center, University of Miyazaki, Kihara 5200, Kiyotake, Miyazaki 889-1692, Japan

書誌事項

公開日
2025
資源種別
journal article
DOI
  • 10.1538/expanim.24-0017
公開者
公益社団法人 日本実験動物学会

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説明

<p> Physiological responses to inhaled anesthetics vary among species. Therefore, a precise anesthetic technique is important for each individual species. In this study, we focused on the degu (Octodon degus), a small herbivorous rodent. Degus have recently begun to be used as laboratory models for brain research because of certain human-like characteristics, such as spontaneous development of Alzheimer’s disease. In this study, we evaluated appropriate induction and maintenance anesthesia conditions for isoflurane and sevoflurane in degus by a stimulation test, electroencephalography (EEG), minimum alveolar concentration (MAC), and vital signs. During induction, more rapid time to loss of the righting reflex and deeper anesthesia in degus were observed in isoflurane. The MAC value for degus were 1.75 ± 0.0% in isoflurane and 2.25 ± 0.27% in sevoflurane. Whereas some degus were awake during maintenance anesthesia using both anesthetics at concentrations of ≤2%, no rats were awake when using sevoflurane at a concentration of 2%. The duration of the total flat EEG, a measure of the depth of maintenance anesthesia, was longer for isoflurane than for sevoflurane. Furthermore, higher concentrations of both anesthetics suppressed the respiratory rate in degus. These new findings regarding inhalation anesthesia in degus will contribute to future developments in the fields of laboratory animals and veterinary medicine.</p>

収録刊行物

  • Experimental Animals

    Experimental Animals 74 (1), 93-103, 2025

    公益社団法人 日本実験動物学会

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