{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390021920647207808.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1295/kobunshi.74.3_128"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/kobunshi/74/3/74_128/_pdf"}}],"dc:title":[{"@language":"en","@value":"Design of Biocompatible Soft-Biomaterials"},{"@language":"ja","@value":"生体親和性ソフトバイオマテリアルの設計"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"

We investigated human umbilical vein endothelial cells (HUVECs)-polymer and platelet-polymer interaction behavior by measuring the adhesion strength using single-cell force spectroscopy. The hydration state of the polymer interface was observed using frequency-modulation atomic force microscopy. We discovered that HUVECs can attach and spread on the poly(2-methoxyethyl acrylate) (PMEA) with strong adhesion strength compared to other polymers. We also discovered that the hydration layers on the PMEA were closely related to their weak platelet adhesion behavior. Cell adhesions and denaturation degree of adsorbed proteins were controlled by intermediate water (IW) contents. Based on our results, it can be concluded that PMEA is a promising candidate for the construction of stents and artificial small-diameter blood vessels owing to the presence of IW on the biointerface. Using the principle of IW, which is common in hydrated biomolecules and biocompatible polymers, we found the synthetic methodology to create novel functional polymers moving toward a more high-throughput way. The concept provides significant opportunities for pioneering medical devices.

"},{"@language":"ja","@value":"1．はじめに
\n医療分野はわが国の成長戦略に位置付けられ、国際競争力のある製品開発への取り組みが期待されている。高齢社会において健康長寿の実現のためにニーズの大きい製品には、生体親和性が必須である。また、より"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410021920647207808","@type":"Researcher","foaf:name":[{"@language":"en","@value":"TANAKA Masaru"},{"@language":"ja","@value":"田中 賢"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"九州大学先導物質化学研究所ソフトマテリアル部門ソフトマテリアル学際化学分野"},{"@language":"en","@value":"Kyushu University"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"04541138"},{"@type":"LISSN","@value":"04541138"},{"@type":"EISSN","@value":"21859825"}],"prism:publicationName":[{"@language":"en","@value":"POLYMERS"},{"@language":"ja","@value":"高分子"},{"@language":"en","@value":"Kobunshi"},{"@language":"ja","@value":"高分子"}],"dc:publisher":[{"@language":"en","@value":"The Society of Polymer Science, Japan"},{"@language":"ja","@value":"公益社団法人 高分子学会"}],"prism:publicationDate":"2025","prism:volume":"74","prism:number":"3","prism:startingPage":"128","prism:endingPage":"129"},"reviewed":"false","url":[{"@id":"https://www.jstage.jst.go.jp/article/kobunshi/74/3/74_128/_pdf"}],"availableAt":"2025","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Hydration%20Water","dc:title":"Hydration Water"},{"@id":"https://cir.nii.ac.jp/all?q=Hydrated%20Polymer","dc:title":"Hydrated Polymer"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Adsorption","dc:title":"Protein Adsorption"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Adhesion","dc:title":"Cell Adhesion"},{"@id":"https://cir.nii.ac.jp/all?q=Medical%20Devices","dc:title":"Medical Devices"},{"@id":"https://cir.nii.ac.jp/all?q=Stents","dc:title":"Stents"},{"@id":"https://cir.nii.ac.jp/all?q=Surfaces","dc:title":"Surfaces"},{"@id":"https://cir.nii.ac.jp/all?q=Biointerfaces","dc:title":"Biointerfaces"},{"@id":"https://cir.nii.ac.jp/all?q=Hydration%20Water","dc:title":"Hydration Water"},{"@id":"https://cir.nii.ac.jp/all?q=Hydrated%20Polymer","dc:title":"Hydrated Polymer"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Adsorption","dc:title":"Protein Adsorption"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Adhesion","dc:title":"Cell Adhesion"},{"@id":"https://cir.nii.ac.jp/all?q=Medical%20Devices","dc:title":"Medical Devices"},{"@id":"https://cir.nii.ac.jp/all?q=Stents","dc:title":"Stents"},{"@id":"https://cir.nii.ac.jp/all?q=Surfaces","dc:title":"Surfaces"},{"@id":"https://cir.nii.ac.jp/all?q=Biointerfaces","dc:title":"Biointerfaces"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360017279832686080","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Simultaneous control of the mechanical properties and adhesion of human umbilical vein endothelial cells to suppress platelet adhesion on a supramolecular 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