{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390022543037990272.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1267/ahc.25-00002"}},{"identifier":{"@type":"HDL","@value":"http://hdl.handle.net/10458/0002001286"}},{"identifier":{"@type":"URI","@value":"https://miyazaki-u.repo.nii.ac.jp/records/2001286"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/ahc/58/2/58_25-00002/_pdf"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Non-Cytotoxic Photodynamic Therapy with Talaporfin Sodium Reduces the Expression of CXCR4 and Enhances Chemotherapeutic Efficacy in Undifferentiated Gastric Cancer Cell Line HGC27"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"<p>Gastric cancer (GC), particularly the undifferentiated type, is frequently associated with peritoneal metastasis, which significantly worsens prognosis due to its resistance to conventional treatments. Photodynamic therapy (PDT) is localized treatment using a photosensitizer (PS) activated by light of a specific wavelength to generate cytotoxic reactive oxygen species that induce cell death. Severe adverse events were reported from clinical trials investigating PDT for peritoneal dissemination conducted until the early 2000s, leaving its safety and clinical effectiveness unestablished. The present study explored whether “non-cytotoxic” PDT using talaporfin sodium (TS) could enhance efficacy of chemotherapeutic agents in undifferentiated GC cell line HGC27. Cell viability was evaluated with MTT assay following TS-PDT, and the synergistic effect between non-cytotoxic TS-PDT and anticancer drug SN-38 was assessed. Changes in expression of drug resistance markers were analyzed through qRT-PCR, Western blotting, and immunocytochemistry. We found that non-cytotoxic TS-PDT enhanced the efficacy of chemotherapy in the undifferentiated GC cell line and reduced the expression of C-X-C chemokine receptor type 4, a key marker associated with GC stem-like properties. These findings highlight the potential of non-cytotoxic TS-PDT as a synergistic treatment approach. We conclude that non-cytotoxic TS-PDT could enhance drug sensitivity and offers a promising therapeutic strategy for GC.</p>"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420282801192322176","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90851585"},{"@type":"NRID","@value":"1000090851585"}],"foaf:name":[{"@language":"en","@value":"Kai Kengo"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Anatomy, Histochemistry and Cell Biology, Faculty of Medicine, University of Miyazaki"},{"@language":"en","@value":"Department of Surgery, Faculty of Medicine, University of 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Yoshitaka"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Anatomy, Histochemistry and Cell Biology, Faculty of Medicine, University of Miyazaki"},{"@language":"en","@value":"Frontier Science Research Center, Faculty of Medicine, University of Miyazaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751163979008","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60380838"},{"@type":"NRID","@value":"1000060380838"},{"@type":"NRID","@value":"9000257837110"},{"@type":"NRID","@value":"9000258223598"},{"@type":"NRID","@value":"9000283471793"},{"@type":"NRID","@value":"9000409993567"},{"@type":"NRID","@value":"9000409861769"}],"foaf:name":[{"@language":"en","@value":"Nanashima Atsushi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Surgery, Faculty of Medicine, University of Miyazaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1410022543037990273","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Mori Ryoma"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Applied Chemistry, Faculty of Engineering, University of Miyazaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276190515456","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90363572"},{"@type":"NRID","@value":"1000090363572"},{"@type":"NRID","@value":"9000006818883"},{"@type":"NRID","@value":"9000261677127"},{"@type":"NRID","@value":"9000003801997"},{"@type":"NRID","@value":"9000301712583"},{"@type":"NRID","@value":"9000256025652"},{"@type":"NRID","@value":"9000000966190"},{"@type":"NRID","@value":"9000256029841"},{"@type":"NRID","@value":"9000273020188"},{"@type":"NRID","@value":"9000257729652"},{"@type":"NRID","@value":"9000257726441"},{"@type":"NRID","@value":"9000000476310"},{"@type":"NRID","@value":"9000257733003"},{"@type":"NRID","@value":"9000413237797"},{"@type":"NRID","@value":"9000019960505"},{"@type":"NRID","@value":"9000255702380"},{"@type":"NRID","@value":"9000256028403"},{"@type":"NRID","@value":"9000396109920"},{"@type":"NRID","@value":"9000256024300"},{"@type":"NRID","@value":"9000257722003"},{"@type":"NRID","@value":"9000347128002"},{"@type":"NRID","@value":"9000409993566"},{"@type":"NRID","@value":"9000389944011"},{"@type":"NRID","@value":"9000413238490"},{"@type":"NRID","@value":"9000257732845"},{"@type":"NRID","@value":"9000255702873"},{"@type":"NRID","@value":"9000283299225"},{"@type":"NRID","@value":"9000275831300"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0111275"}],"foaf:name":[{"@language":"en","@value":"Matsumoto Jin"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Applied Chemistry, Faculty of Engineering, University of Miyazaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1410021857378031872","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90979361"},{"@type":"NRID","@value":"1000090979361"}],"foaf:name":[{"@language":"en","@value":"Higuchi Kazuhiro"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Surgery, Faculty of Medicine, University of Miyazaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1410022543037990272","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Fidya"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Anatomy, Histochemistry and Cell Biology, Faculty of Medicine, University of Miyazaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1410022543037990282","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Shimamawari Koki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Applied Chemistry, Faculty of Engineering, University of Miyazaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326210874368","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50700085"},{"@type":"NRID","@value":"1000050700085"},{"@type":"NRID","@value":"9000409011231"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/takumiishizuka"}],"foaf:name":[{"@language":"en","@value":"Ishizuka Takumi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Anatomy, Histochemistry and Cell Biology, Faculty of Medicine, University of Miyazaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1410022543037990277","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Kubota Toshiki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Anatomy, Histochemistry and Cell Biology, Faculty of Medicine, University of Miyazaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1410022543037990278","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Lkham-Erdene Baljinnyam"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Anatomy, Histochemistry and Cell Biology, Faculty of Medicine, University of Miyazaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276185350400","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40612370"},{"@type":"NRID","@value":"1000040612370"},{"@type":"NRID","@value":"9000404094647"}],"foaf:name":[{"@language":"en","@value":"Ikenoue Makoto"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Surgery, Faculty of Medicine, University of 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Cytochem."},{"@language":"en","@value":"Acta Histochemica et Cytochemica"},{"@language":"en","@value":"Acta Histochem. Cytochem"},{"@language":"ja","@value":"Ａｃｔａ　Ｈｉｓｔｏｃｈｅｍｉｃａ　ｅｔ　Ｃｙｔｏｃｈｅｍｉｃａ"},{"@language":"ja","@value":"Ａｃｔａ　Ｈｉｓｔｏｃｈｅｍ．　Ｃｙｔｏｃｈｅｍ"}],"dc:publisher":[{"@language":"en","@value":"JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY"},{"@language":"ja","@value":"日本組織細胞化学会"}],"prism:publicationDate":"2025-04-26","prism:volume":"58","prism:number":"2","prism:startingPage":"69","prism:endingPage":"79"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://miyazaki-u.repo.nii.ac.jp/records/2001286"},{"@id":"https://www.jstage.jst.go.jp/article/ahc/58/2/58_25-00002/_pdf"}],"availableAt":"2025-04-26","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=photodynamic%20therapy","dc:title":"photodynamic therapy"},{"@id":"https://cir.nii.ac.jp/all?q=gastric%20cancer%20cell","dc:title":"gastric cancer cell"},{"@id":"https://cir.nii.ac.jp/all?q=non-cytotoxic%20PDT","dc:title":"non-cytotoxic PDT"},{"@id":"https://cir.nii.ac.jp/all?q=synergistic%20treatment","dc:title":"synergistic treatment"},{"@id":"https://cir.nii.ac.jp/all?q=C-X-C%20chemokine%20receptor%20type%204","dc:title":"C-X-C chemokine receptor type 4"}],"dcterms:subject":[{"subjectScheme":"Other","notation":[{"@language":"en","@value":"C-X-C chemokine receptor type 4"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"gastric cancer cell"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"non-cytotoxic PDT"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"photodynamic therapy"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"synergistic treatment"}]}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040018274934208384","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24K11937"},{"@type":"JGN","@value":"JP24K11937"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K11937/"}],"notation":[{"@language":"ja","@value":"PDP効果に基づく胃癌腹膜播種に対する簡便かつ安全な光治療の開発"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050564285805333248","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A multicenter phase II study of salvage photodynamic therapy using talaporfin sodium (ME2906) and a diode laser (PNL6405EPG) for local failure after chemoradiotherapy or radiotherapy for esophageal cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232015595008","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Photodynamic therapy of human biliary 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