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Targeting Mitochondria to Inhibit Aflatoxin Production: Mechanistic Insight
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- Kushiro Masayo
- Institute of Food Research, National Agriculture and Food Research Organization (NARO), 2-1-12 Kannondai, Tsukuba, Ibaraki 305-8642, Japan
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- Furukawa Tomohiro
- Institute of Food Research, National Agriculture and Food Research Organization (NARO), 2-1-12 Kannondai, Tsukuba, Ibaraki 305-8642, Japan
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- Nakagawa Hiroyuki
- Research Center for Advanced Analysis, Core Technology Research Headquarters, NARO, 2-1-12 Kannondai, Tsukuba, Ibaraki 305-8642, Japan
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- Sakuda Shohei
- Faculty of Science and Engineering, Teikyo University, 1-1 Toyosatodai, Utsunomiya, Tochigi 320-8551, Japan
Bibliographic Information
- Published
- 2025
- DOI
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- 10.14252/foodsafetyfscj.d-25-00001
- Publisher
- Food Safety Commission, Cabinet Office, Government of Japan
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Description
<p>Contamination of agricultural crops by aflatoxin, a potent carcinogenic fungal toxin, is a global issue that poses serious health risks to humans and livestock while inflicting significant economic damage on the agricultural sector. Specific inhibitors of aflatoxin production hold promise not only as effective agents for controlling aflatoxin contamination, but also as valuable tools for uncovering the regulatory mechanisms of secondary metabolism through the elucidation of their modes of action. Unexpectedly, inhibitors whose modes of action we have clarified were found to target mitochondrial components, rather than proteins directly involved in the aflatoxin biosynthetic pathway. In this article, we review inhibitors and inhibitory mixtures that act on mitochondria and explore the relationship between mitochondrial function and aflatoxin production through their modes of action.</p>
Journal
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- Food Safety
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Food Safety 13 (3), 46-55, 2025
Food Safety Commission, Cabinet Office, Government of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390024246558378496
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- ISSN
- 21878404
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
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- Abstract License Flag
- Disallowed
