Discovery of Feeding Regulatory Peptides and The Importance of Peptide Discovery Research
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- IDA TAKANORI
- Division for Identification and Analysis of Bioactive Peptides, Department of Bioactive Peptides, Frontier Science Research Center, University of Miyazaki
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- MATSUI KAZUMA
- Division of Molecular Genetics, Institute of Life Science, Kurume University
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- NAGATA SAYAKA
- Department of Food Science and Technology, Faculty of Health and Nutrition, Minami Kyushu University
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- NAKAMACHI TOMOYA
- Laboratory of Regulatory Biology, Faculty of Science, Academic Assembly, University of Toyama
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- SHIIMURA YUKI
- Division of Molecular Genetics, Institute of Life Science, Kurume University Department of Cell Biology, Graduate School of Medicine, Kyoto University
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- SATO TAKAHIRO
- Division of Molecular Genetics, Institute of Life Science, Kurume University
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- KOJIMA MASAYASU
- Division of Molecular Genetics, Institute of Life Science, Kurume University
書誌事項
- 公開日
- 2024-12-31
- 資源種別
- journal article
- DOI
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- 10.2739/kurumemedj.ms7134001
- 公開者
- 久留米大学医学部 The Kurume Medical Journal 編集部
この論文をさがす
説明
<p>Summary: Bioactive peptides consist of multiple linked amino acids that are secreted from cells and act on specific receptors in order to transmit information from one cell to another. Through signal transduction, bioactive peptides regulate various physiological functions in the body, and the discovery of new bioactive peptides is therefore likely to lead to the development of various diagnostic and therapeutic agents. In this article, we have focused on the bioactive peptides that are known as feeding regulatory peptides. They are among the bioactive peptides discovered as ligands for G protein-coupled receptors (GPCRs), and we have reviewed their diverse functions. In addition, the status of structural analysis of GPCRs, which is necessary in the drug discovery process, and research on orphan GPCRs, for which new ligands are expected to be discovered in the future, is introduced to systematize modern peptide research and discuss future developments in bioactive peptide research.</p>
収録刊行物
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- Ｔｈｅ Ｋｕｒｕｍｅ Ｍｅｄｉｃａｌ Ｊｏｕｒｎａｌ
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Ｔｈｅ Ｋｕｒｕｍｅ Ｍｅｄｉｃａｌ Ｊｏｕｒｎａｌ 71 (3.4), 89-109, 2024-12-31
久留米大学医学部 The Kurume Medical Journal 編集部