Simulation study of helper T cell growth and differentiation

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  • NAKAOKA Shinji
    理化学研究所免疫・アレルギー科学総合研究センター
  • AIHARA Kazuyuki
    東京大学生産技術研究所　情報・エレクトロニクス系部門

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Other Title
  • ヘルパーT細胞の増殖・分化シミュレーション
  • ヘルパー Tサイボウ ノ ゾウショク ・ ブンカ シミュレーション

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Description

Helper T cells emerge from naive T cells via lineage commitment. Helper T cells play a pivotal role in adaptive immune response to remove antigen. Most of previous mathematical studies only consider either population dynamics of T cell clonal expansion or intracellular change of gene expression for transcription factors. In the present paper, on the other hand, we construct an individual based model which describes intra- and inter-cellular dynamics of T cell lineage commitment, and then carry out stochastic simulations to investigate how balance between two specific subsets is maintained. The method presented here can be effectively utilized to trace dynamics of a cell population such as immune cells which generically change their behavioral pattern during development.

Journal

  • SEISAN KENKYU

    SEISAN KENKYU 65 (3), 273-280, 2013

    Institute of Industrial Science The University of Tokyo

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