{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679067891712.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.5650/jos.58.355"}},{"identifier":{"@type":"COI","@value":"1:STN:280:DC%2BD1MzptVakuw%3D%3D"}},{"identifier":{"@type":"PMID","@value":"19491530"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"10251872"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/10251872"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I10251872"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/jos/58/7/58_7_355/_pdf"}},{"identifier":{"@type":"NAID","@value":"130000126086"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2009310321"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Dietary Alpha-Linolenic Acid Inhibits Angiotensin-Converting Enzyme Activity and mRNA Expression Levels in the Aorta of Spontaneously Hypertensive Rats"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Several studies have shown that dietary alpha-linolenic acid (ALA) is associated with a reduced risk of cardiovascular disease and has an antihypertensive effect. Blood pressure is regulated mainly by angiotensin-converting enzyme (ACE). In the present study, we investigated the effect of dietary ALA on ACE to clarify the mechanism of the antihypertensive effect in spontaneously hypertensive rats (SHR). Six-week-old SHR were fed a diet containing either 10% ALA-rich flaxseed oil or high oleic safflower oil as a control for four weeks. Systolic blood pressure (SBP) was measured by the tail cuff method once weekly. At the end of the feeding period, ACE activity was determined in the heart, aorta, lung and kidney. ACE mRNA in these organs was also measured by real-time PCR analysis. SBP in the ALA group was significantly lower than in the control group at 2, 3, and 4 weeks. The ACE activity and mRNA expression levels in the ALA group were significantly lower than in the control only in the aorta. In conclusion, the present findings suggest that the blood pressure-lowering mechanism of dietary ALA may be involved in the reduction of ACE activity and mRNA expression levels in the aorta of SHR."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679067891712","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021929016"}],"foaf:name":[{"@language":"en","@value":"Takeuchi Hiroyuki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Central Research Laboratory, The Nisshin OilliO Group, Ltd."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679067891715","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021929008"}],"foaf:name":[{"@language":"en","@value":"Ogawa Akiko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Central Research Laboratory, The Nisshin OilliO Group, Ltd."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679067891713","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021929015"}],"foaf:name":[{"@language":"en","@value":"Aoyama Toshiaki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Central Research Laboratory, The Nisshin OilliO Group, Ltd."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679067891714","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021929011"}],"foaf:name":[{"@language":"en","@value":"Suzuki Yo"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Central Research Laboratory, The Nisshin OilliO Group, Ltd."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13458957"},{"@type":"LISSN","@value":"13458957"},{"@type":"EISSN","@value":"13473352"},{"@type":"CODEN","@value":"JOSOAP"},{"@type":"NDL_BIB_ID","@value":"000000163016"},{"@type":"ISSN","@value":"13458957"},{"@type":"NCID","@value":"AA11503337"}],"prism:publicationName":[{"@language":"en","@value":"Journal of Oleo Science"},{"@language":"en","@value":"J. Oleo Sci."}],"dc:publisher":[{"@language":"en","@value":"Japan Oil Chemists' Society"},{"@language":"ja","@value":"公益社団法人 日本油化学会"}],"prism:publicationDate":"2009","prism:volume":"58","prism:number":"7","prism:startingPage":"355","prism:endingPage":"360"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/bib/10251872"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I10251872"},{"@id":"https://www.jstage.jst.go.jp/article/jos/58/7/58_7_355/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2009310321"}],"availableAt":"2009","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=alpha-linolenic%20acid","dc:title":"alpha-linolenic acid"},{"@id":"https://cir.nii.ac.jp/all?q=hypertension","dc:title":"hypertension"},{"@id":"https://cir.nii.ac.jp/all?q=angiotensin-converting%20enzyme","dc:title":"angiotensin-converting enzyme"},{"@id":"https://cir.nii.ac.jp/all?q=aorta","dc:title":"aorta"},{"@id":"https://cir.nii.ac.jp/all?q=spontaneously%20hypertensive%20rats","dc:title":"spontaneously hypertensive rats"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011143820702848","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Blood Pressure and Stroke"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146547686400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Local renin-angiotensin systems"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619183842048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Comparative study of the blood pressure effects of four different vegetable fats on young, spontaneously hypertensive rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620313417856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Angiotensin I converting enzyme."}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095733307904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"α-Linolenic Acid and Risk of Nonfatal Acute Myocardial Infarction"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096049976448","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Food Omega-3 Fatty Acid Intake of Individuals (Total, Linolenic Acid, Long-Chain) and Their Blood Pressure"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570549809152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"THE VASCULAR TISSUE ANGIOTENSIN I‐CONVERTING ENZYME ACTIVITY AND AORTIC ELASTIN CONTENT IN STROKE‐PRONE SPONTANEOUSLY HYPERTENSIVE RATS FED FISH DIET"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570815573120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571536252160","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dietary Linolenic Acid Is Associated With a Lower Prevalence of Hypertension in the NHLBI Family Heart Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521235496448","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of a diet rich in linseed oil on complex viscosity and blood pressure in spontaneously hypertensive rats (SHR)"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468411382016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Vascular Angiotensin-Converting Enzyme Activity in Man and other Species"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469797499136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dietary α-Linolenic Acid Intake and Risk of Sudden Cardiac Death and Coronary Heart Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470554445696","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Angiotensin Converting Enzyme (ACE) in the Kidney"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419487351936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"THE TISSUE RENIN‐ANGIOTENSIN SYSTEM AND ITS FUNCTIONAL ROLE"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419680601088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Antihypertensive effect of dietary sunflowerseed oil and linseed oil in spontaneously hypertensive rats during a multigeneration feeding study"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420823344256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Systolic and Diastolic Blood Pressure Lowering as Determinants of Cardiovascular Outcome"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895321744896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genetic Linkage of the\n            <i>ACE</i>\n            Gene to Plasma Angiotensin-Converting Enzyme Activity but Not to Blood 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Seeds and Oxidative Stability of Cold-pressed Oil (Green Nut Oil)"},{"@value":"Physicochemical Properties of Plukenetia volubilis L. Seeds and Oxidative Stability of Cold-pressed Oil (Green Nut Oil)"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204721436544","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Significant Target Organs for Hypertension and Cardiac Hypertrophy by Angiotensin-Converting Enzyme Inhibitors"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205234780928","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effectiveness of Active Dietary Education Program Including Flaxseed Oil Intake in Improving Metabolic Syndrome"},{"@language":"ja","@value":"メタボリックシンドローム改善のための亜麻仁油摂取を含む実践プログラムに基づく栄養教育効果の評価"},{"@language":"ja-Kana","@value":"メタボリックシンドローム カイゼン ノ タメ ノ アマニユ セッシュ オ フクム ジッセン プログラム ニ モトズク エイヨウ キョウイク コウカ ノ ヒョウカ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679068720000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Lowering Systolic Blood Pressure and Increases in Vasodilator Levels in SHR with Oral .ALPHA.-Linolenic Acid Administration"},{"@value":"Lowering systolic blood pressure and increases in vasodilator levels in SHR with oral α-linolenic acid administration"},{"@language":"ja-Kana","@value":"Lowering systolic blood pressure and increases in vasodilator levels in SHR with oral a linolenic acid administration"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679069042688","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Favorable Effects of Flaxseed Supplemented Diet on Liver and Kidney Functions in Hypertensive Wistar Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681451681408","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Design of a Highly Potent Anti-hypertensive Peptide Based on Ovokinin(2-7)."}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0033162837"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I10251872"},{"@type":"CROSSREF","@value":"10.5650/jos.58.355"},{"@type":"PUBMED","@value":"19491530"},{"@type":"CIA","@value":"130000126086"},{"@type":"CROSSREF","@value":"10.5650/jos.62.709_references_DOI_SAdnAriAtKc9HVXoiCT02bvIKYm"},{"@type":"CROSSREF","@value":"10.3136/fstr.19.875_references_DOI_SAdnAriAtKc9HVXoiCT02bvIKYm"}]}