{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679069498880.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.5650/jos.ess15044"}},{"identifier":{"@type":"PMID","@value":"26136176"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"026523381"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/026523381"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I026523381"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/jos/64/7/64_ess15044/_pdf"}},{"identifier":{"@type":"NAID","@value":"130005085917"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2016061676"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Competitive Solubilization of Cholesterol/Cholesteryl Oleate and Seven Species of Sterol/Stanol in Model Intestinal Solution System"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"The addition of plant sterols/stanols (sterols or stanols) can reduce the solubilization of cholesterol in a model intestinal solution system. We studied the molecular structure of seven different sterols/stanols and the effect they had on the solubilization of cholesterol or cholesterol ester in a model intestinal solution. The differences in the molecular structures of the sterol/stanol species influenced their abilities to reduce the solubility of cholesterol in the competitive solubilization experiments. Cholestanol whose molecular structure resembled cholesterol was the most effective at reducing the solubilization of cholesterol and cholesterol ester, with the solubilities of cholesterol and cholesteryl oleate being 41% and 39% respectively of the values observed for the single solubilizate systems. <i>β</i>-Sitosterol was also able to reduce the solubilities of cholesterol and cholesteryl oleate to 43% and 45% of those observed in a single solubilizate system. Both, stigmasterol and brassicasterol have an unsaturated double bond in a steroid side chain and did not exhibit major cholesterol-lowering effects. These results were reflected by the Gibbs free energy change values (Δ<i>G</i><sup>0</sup>) for solubilization, where the sterol/stanol species with cholesterol-lowering effects had similar or larger negative Δ<i>G</i><sup>0</sup> values than those observed for cholesterol."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420845751145109248","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90384635"},{"@type":"NRID","@value":"1000090384635"},{"@type":"NRID","@value":"9000001462489"},{"@type":"NRID","@value":"9000297482089"},{"@type":"NRID","@value":"9000367427878"},{"@type":"NRID","@value":"9000256026292"},{"@type":"NRID","@value":"9000409288418"},{"@type":"NRID","@value":"9000256024345"},{"@type":"NRID","@value":"9000258615313"},{"@type":"NRID","@value":"9000256012518"},{"@type":"NRID","@value":"9000347641887"},{"@type":"NRID","@value":"9000412545777"},{"@type":"NRID","@value":"9000009798419"},{"@type":"NRID","@value":"9000404106028"},{"@type":"NRID","@value":"9000409288396"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/matsuokakei"}],"foaf:name":[{"@language":"en","@value":"Matsuoka Keisuke"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Faculty of Education, Laboratory of Chemistry, Saitama University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679069498882","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000297482090"}],"foaf:name":[{"@language":"en","@value":"Kase Asumi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Physical Chemistry, Showa Pharmaceutical University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679069498883","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000297482091"}],"foaf:name":[{"@language":"en","@value":"Matsuo Takashi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Physical Chemistry, Showa Pharmaceutical University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679069498880","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000297482092"}],"foaf:name":[{"@language":"en","@value":"Ashida Yusuke"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Physical Chemistry, Showa Pharmaceutical University"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13458957"},{"@type":"LISSN","@value":"13458957"},{"@type":"EISSN","@value":"13473352"},{"@type":"CODEN","@value":"JOSOAP"},{"@type":"NDL_BIB_ID","@value":"000000163016"},{"@type":"ISSN","@value":"13458957"},{"@type":"NCID","@value":"AA11503337"}],"prism:publicationName":[{"@language":"en","@value":"Journal of Oleo Science"},{"@language":"en","@value":"J. Oleo Sci."}],"dc:publisher":[{"@language":"en","@value":"Japan Oil Chemists' Society"},{"@language":"ja","@value":"公益社団法人 日本油化学会"}],"prism:publicationDate":"2015","prism:volume":"64","prism:number":"7","prism:startingPage":"783","prism:endingPage":"791"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://id.ndl.go.jp/bib/026523381"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I026523381"},{"@id":"https://www.jstage.jst.go.jp/article/jos/64/7/64_ess15044/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2016061676"}],"availableAt":"2015","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=bile%20salt","dc:title":"bile salt"},{"@id":"https://cir.nii.ac.jp/all?q=solubilization","dc:title":"solubilization"},{"@id":"https://cir.nii.ac.jp/all?q=cholesterol","dc:title":"cholesterol"},{"@id":"https://cir.nii.ac.jp/all?q=sterol","dc:title":"sterol"},{"@id":"https://cir.nii.ac.jp/all?q=stanol","dc:title":"stanol"},{"@id":"https://cir.nii.ac.jp/all?q=model%20intestinal%20solution","dc:title":"model intestinal solution"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011146638127232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mortality by cause for eight regions of the world: Global Burden of Disease Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182007202304","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Competitive solubilization of cholesterol and six species of sterol/stanol in bile salt micelles"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093728693632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 1. Phase behavior and aggregation states of model lipid systems patterned after aqueous duodenal contents of healthy adult human beings"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094202442496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Micelle formation of sodium cholate and solubilization into the micelle"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846640789674752","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Competitive solubilization of cholesterol and β-sitosterol with changing biliary lipid compositions in model intestinal solution"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569535764608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Plant stanol and sterol esters in prevention of cardiovascular diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044111414784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Comparison of Efficacy of Plant Stanol Ester and Sterol Ester: Short-Term and Longer-Term Studies"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044901012736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Efficacy and Safety of Plant Stanols and Sterols in the Management of Blood Cholesterol Levels"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045521988224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Thermodynamic and molecular determinants of sterol solubilities in bile salt micelles"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045522327808","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of phytosterols and phytostanols on the solubilization of cholesterol by dietary mixed micelles: an in vitro study"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519159278080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Selective Solubilization of Sterols by Bile Salt Micelles in Water:  A Thermodynamic Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520560449408","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"O/W Emulsion of <i>n</i>-Alkylbenzene/Ionic Surfactant/Water Systems"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994911372672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Solubility in and affinity for the bile salt micelle of plant sterols are important determinants of their intestinal absorption in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469114421120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Study of thermodynamic parameters for solubilization of plant sterol and stanol in bile salt micelles"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943550359040","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Solubilization of cholesterol and polycyclic aromatic compounds into sodium bile salt micelles (Part 2)"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944688926848","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Temperature dependence of solubilities in water and heats of fusion of solid aromatic hydrocarbons"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895374506496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Solubilisation micellaire du cholestérol par les sels biliaires et les lecithines extraits de la bile humaine"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369478177024","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Thermodynamic study on competitive solubilization of cholesterol and β-sitosterol in bile salt micelles"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370948121984","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nonesterified Phytosterols Dissolved and Recrystallized in Oil Reduce Plasma Cholesterol in Gerbils and Humans"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318936314624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Quasielastic light-scattering studies of aqueous biliary lipid systems. Mixed micelle formation in bile salt-lecithin solutions"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793766095616","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Influence of processing on sterols of edible vegetable oils"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269691048192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Metabolic effects of plant sterols and stanols (Review)"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270182751232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Preparation and Properties of a Cholesterol Oxidase from Nocardia sp. and Its Application to the Enzymatic Assay of Total Cholesterol in Serum"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206325163136","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of sitosterol and sitostanol on micellar solubility of cholesterol."}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206326531840","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Hypolipidemic Effect of the Autoclaved Extract Prepared from Pea (<i>Pisum sativum</i> L.) Pods In Vivo and In Vitro"},{"@value":"Hypolipidemic Effect of the Autoclaved Extract Prepared from Pea (Pisum sativum L.) Pods In Vivo and In Vitro"}]},{"@id":"https://cir.nii.ac.jp/crid/1522543654672065536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NMR study on solubilization of sterols and aromatic compounds in sodium taurodeoxycholate micelles"},{"@language":"ja-Kana","@value":"NMR study on solubilization of sterols and aromatic compounds in sodium taurodeoxycholate micelles"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:2000659166"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I026523381"},{"@type":"CROSSREF","@value":"10.5650/jos.ess15044"},{"@type":"PUBMED","@value":"26136176"},{"@type":"CIA","@value":"130005085917"},{"@type":"OPENAIRE","@value":"doi_dedup___::abb21669ee2cfd6894e6634a2f6ca5fd"},{"@type":"CROSSREF","@value":"10.3177/jnsv.62.322_references_DOI_KuQcYsUx9QSnFR5tE6CHaskuQ4m"}]}