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The <i>β</i>-(phosphonoxy)ethyl (PE) and carboxymethyl (CM) analogs of <i>Escherichia coli</i> type having six acyl groups and those of the biosynthetic precursor type having four acyl groups were synthesized via a divergent synthetic route. The <i>E. coli</i> type <i>β</i>-(phosphonoxy)ethyl analog, which was previously reported to be not endotoxic, showed strong immunostimulating activity comparable to the natural-type <i>α</i>-analog. The acidic functional groups are concluded to be essential but their strict spatial arrangement is not required for expression of the biological activity."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326235681152","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80192722"},{"@type":"NRID","@value":"1000080192722"},{"@type":"NRID","@value":"9000021782546"},{"@type":"NRID","@value":"9000253073817"},{"@type":"NRID","@value":"9000256026962"},{"@type":"NRID","@value":"9000256020200"},{"@type":"NRID","@value":"9000256018585"},{"@type":"NRID","@value":"9000242565785"},{"@type":"NRID","@value":"9000311788303"},{"@type":"NRID","@value":"9000406221776"},{"@type":"NRID","@value":"9000256016071"},{"@type":"NRID","@value":"9000002162633"},{"@type":"NRID","@value":"9000021878200"},{"@type":"NRID","@value":"9000404852052"},{"@type":"NRID","@value":"9000256008892"},{"@type":"NRID","@value":"9000257738182"},{"@type":"NRID","@value":"9000021805970"},{"@type":"NRID","@value":"9000256022462"},{"@type":"NRID","@value":"9000257728237"},{"@type":"NRID","@value":"9000409009219"},{"@type":"NRID","@value":"9000404530379"},{"@type":"NRID","@value":"9000256011452"},{"@type":"NRID","@value":"9000006764310"},{"@type":"NRID","@value":"9000020727089"},{"@type":"NRID","@value":"9000021765560"},{"@type":"NRID","@value":"9000411532888"},{"@type":"NRID","@value":"9000283394357"},{"@type":"NRID","@value":"9000019241104"},{"@type":"NRID","@value":"9000403403446"},{"@type":"NRID","@value":"9000255696961"},{"@type":"NRID","@value":"9000002144424"},{"@type":"NRID","@value":"9000406018103"},{"@type":"NRID","@value":"9000001472029"},{"@type":"NRID","@value":"9000021867722"},{"@type":"NRID","@value":"9000353371892"},{"@type":"NRID","@value":"9000397864514"},{"@type":"NRID","@value":"9000403403449"},{"@type":"NRID","@value":"9000256020827"},{"@type":"NRID","@value":"9000260215456"},{"@type":"NRID","@value":"9000021870098"},{"@type":"NRID","@value":"9000410485966"},{"@type":"NRID","@value":"9000258733676"},{"@type":"NRID","@value":"9000408488503"},{"@type":"NRID","@value":"9000256016156"},{"@type":"NRID","@value":"9000256020612"},{"@type":"NRID","@value":"9000257723667"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0076573"}],"foaf:name":[{"@language":"en","@value":"Fukase 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