{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679121947136.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.7164/antibiotics.45.1064"}},{"identifier":{"@type":"COI","@value":"1:CAS:528:DyaK38Xls1eltr8%3D"}},{"identifier":{"@type":"PMID","@value":"1381344"}},{"identifier":{"@type":"NAID","@value":"130003502314"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"WS9326A, a novel tachykinin antagonist isolated from Streptomyces violaceusniger No. 9326. II Biological and pharmacological properties of WS9326A and tetrahydro-WS9326A (FK224)."},{"@value":"WS9326A, a novel tachykinin antagonist isolated from Streptomyces violaceusniger No. 9326. II. Biological and pharmacological properties of WS93326A and terahydro-WS9326A (FK224)"}],"dcterms:alternative":[{"@language":"en","@value":"II. BIOLOGICAL AND PHARMACOLOGICAL PROPERTIES OF WS9326A AND TETRAHYDRO-WS9326A (FK224)"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"WS9326A binds competitively to [<sup>3</sup>H]substance P (NK-1 receptor) binding sites on guinea-pig lung membranes (IC<sub>50</sub> = 3.6 × 10<sup>-6</sup> M), and acts as a tachykinin antagonist in various functional assays.<br> WS9326A inhibited tracheal constrictions produced by exogenously added substance P and neurokinin A, with IC<sub>50</sub> values of 9.7 × 10<sup>-6</sup> M and 3.5 × 10<sup>-6</sup> M, respectively. WS9326A inhibited neurokinin A-induced bronchoconstriction in a dose dependent manner when administered to guinea-pigs intravenously together with neurokinin A, and was also effective in preventing capsaicin-induced bronchoconstriction, which is known to be caused by release of endogenous tachykinins (substance P and neurokinin A).<br> FK224 (tetrahydro-WS9326A; catalytic hydrogenation of WS9326A gave FK224) was more potent than WS9326A in the [<sup>3</sup>H]substance P receptor binding assay using guinea-pig lung membrane (IC<sub>50</sub> = 1.0 × 10<sup>-7</sup> M)."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679121947141","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000253077547"}],"foaf:name":[{"@language":"en","@value":"HASHIMOTO MICHIZANE"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., 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