THE PIVOTAL POSITION OF THE MITOCHONDRIAL THIOL GROUP EXPOSED BY DINITROPHENOL LOCATED BY MEANS OF ATP ENERGIZED MITOCHONDRIAL VOLUME CHANGES REQUIRING GRAMICIDIN, SHOWDOMYCIN, AND DINITRIPHENOL
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- HADLER HERBERT I.
- Department of Chemistry, Southern Illinois University
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- CLAYBOURN BOB E.
- Department of Chemistry, Southern Illinois University
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- TSCHANG TAI Po
- Department of Chemistry, Southern Illinois University
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- MOREAU TERRY L.
- Department of Chemistry, Southern Illinois University
Bibliographic Information
- Other Title
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- The pivotal position of the mitochondrial thiol group exposed by dinitrophenol located by means of ATP energized mitochondrial volume changes requiring gramicidin,showdomycin,and dinitrophenol
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Description
An appropriate concentration of DNP (2, 4-dinitrophenol) is capable of inhibiting the ATP energized mitochondrial volume change induced by gramicidin in the presence of the permeant ions potassium and L-malate. The further addition of the non-mercurial thiol reagent, showdomycin reinstates, an effect of gramicidin which is dependent upon potassium ion. Thus the strategically located nucleophilic mitochondrial thiol group exposed by DNP occupies a pivotal position between two cycles. One of the cycles meshes with the respiratory chain and the other cycle meshes with ATP. This latter cycle contains the site sensitive to gramicidin.
Journal
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- The Journal of Antibiotics
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The Journal of Antibiotics 22 (5), 183-188, 1969
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
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Keywords
Details 詳細情報について
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- CRID
- 1390282679129375488
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- NII Article ID
- 130003498180
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- NII Book ID
- AA0069330X
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- COI
- 1:CAS:528:DyaF1MXkt1Sltbs%3D
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- ISSN
- 18811469
- 00218820
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- NDL BIB ID
- 8510043
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- PubMed
- 5811390
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed