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A Highly Enantioselective Synthesis of Phenylephrine, Levamisole, Carnitine and Propranolol."}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"The complexes of pyrrolidine bisphosphine ligands (CPMs) with rhodium (I) were found to be efficient catalysts for asymmetric hydrogenation of α-amino ketone hydrochloride derivatives. Utilizing this methodology, we have developed efficient asymmetric syntheses of the optically active β-amino alcohols, phenylephrine, levamisole, carnitine and propranolol."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679137755264","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254710656"}],"foaf:name":[{"@language":"en","@value":"SAKURABA Shunji"},{"@language":"ja","@value":"桜庭 俊司"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679137755267","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254710657"}],"foaf:name":[{"@language":"en","@value":"TAKAHASHI Hisashi"},{"@language":"ja","@value":"高橋 寿"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679137755266","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254710658"}],"foaf:name":[{"@language":"en","@value":"TAKEDA Hideo"},{"@language":"ja","@value":"竹田 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Kazuo"},{"@language":"ja","@value":"阿知波 一雄"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00092363"},{"@type":"EISSN","@value":"13475223"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/00092363"}],"prism:publicationName":[{"@language":"ja","@value":"ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ"},{"@language":"en","@value":"Chemical and Pharmaceutical Bulletin"},{"@language":"en","@value":"Chem. Pharm. Bull."},{"@language":"en","@value":"CHEMICAL & PHARMACEUTICAL BULLETIN"},{"@language":"ja","@value":"Ｃｈｅｍ．　Ｐｈａｒｍ．　Ｂｕｌｌ．"}],"dc:publisher":[{"@language":"en","@value":"The Pharmaceutical Society of Japan"},{"@language":"ja","@value":"公益社団法人 日本薬学会"}],"prism:publicationDate":"1995","prism:volume":"43","prism:number":"5","prism:startingPage":"738","prism:endingPage":"747"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://www.jstage.jst.go.jp/article/cpb1958/43/5/43_5_738/_pdf"}],"availableAt":"1995","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=catalytic%20asymmetric%20hydrogenation","dc:title":"catalytic asymmetric hydrogenation"},{"@id":"https://cir.nii.ac.jp/all?q=rhodium%20complex","dc:title":"rhodium complex"},{"@id":"https://cir.nii.ac.jp/all?q=chiral%20bisphosphine","dc:title":"chiral bisphosphine"},{"@id":"https://cir.nii.ac.jp/all?q=%CE%B1-amino%20ketone","dc:title":"α-amino ketone"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004230310462464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Diastereo‐ and Enantioselective <i>anti</i>‐Selective Hydrogenation of α‐Amino‐β‐keto Ester Hydrochlorides and Related Compounds Using Transition‐Metal–Chiral‐Bisphosphine Catalysts"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204170789120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Preparation of Axially Chiral Biphenyl Diphosphine Ligands and Their Application in Asymmetric Hydrogenation"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0003322123"},{"@type":"CROSSREF","@value":"10.1248/cpb.43.738"},{"@type":"CIA","@value":"130003946821"},{"@type":"OPENAIRE","@value":"doi_dedup___::bf7d8f818f6de05a9143a6b75bf6512f"},{"@type":"CROSSREF","@value":"10.1002/tcr.201300032_references_DOI_Dkef7BNBYMjhWYgJsrN2c3ZPYZr"},{"@type":"CROSSREF","@value":"10.1248/cpb.52.1445_references_DOI_Dkef7BNBYMjhWYgJsrN2c3ZPYZr"}]}