{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679138501632.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1248/cpb.32.3620"}},{"identifier":{"@type":"PMID","@value":"6525656"}},{"identifier":{"@type":"URI","@value":"http://www.jstage.jst.go.jp/article/cpb1958/32/9/32_9_3620/_pdf"}},{"identifier":{"@type":"NAID","@value":"130003769707"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Comparative effects of DL, D and L-3-pyridylalanine on serotonin concentration and tryptophan-serotonin metabolizing enzymes."}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"The administration of DL-3-pyridylalanine (DL-3-PA, DL-α-amino-3-pyridinepropanoic acid) or L-3-PA significantly increased brain serotonin (5-HT) concentration without affecting the other tissue 5-HT concentrations in male Wistar rats. The increase in brain 5-HT upon the administration of DL or L-3-PA was maintained for a long time (at least 96h). DL and L-3-PA decreased tryptophan pyrrolase activity in the liver and increased free tryptophan concentration in the serum. These effects found in rats given a 100mg/kg dose of DL-3-PA were not statistically different from those in rats given a 50mg/kg dose of L-3-PA. DL and L-3-PA hardly affected the activities of L-tryptophan 5-hydroxylase, 5-hydroxy-L-tryptophan decarboxylase and monoamine oxidase in the brain. D-3-PA had no effect on 5-HT concentration or tryptophan-5-HT metabolizing enzymes in rats. These results suggest that the action of DL-3-PA is due to L-3-PA, not D-3-PA."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1030003658420811904","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00078693"},{"@type":"NRID","@value":"1000000078693"},{"@type":"NRID","@value":"9000254219277"},{"@type":"NRID","@value":"9000005232203"},{"@type":"NRID","@value":"9000005134662"},{"@type":"NRID","@value":"9000254222854"},{"@type":"NRID","@value":"9000254231273"},{"@type":"NRID","@value":"9000258571860"},{"@type":"NRID","@value":"9000020069462"},{"@type":"NRID","@value":"9000254235644"},{"@type":"NRID","@value":"9000009577425"},{"@type":"NRID","@value":"9000392640117"},{"@type":"NRID","@value":"9000392673735"},{"@type":"NRID","@value":"9000254225041"},{"@type":"NRID","@value":"9000391916610"},{"@type":"NRID","@value":"9000254691415"},{"@type":"NRID","@value":"9000392639595"},{"@type":"NRID","@value":"9000254673880"},{"@type":"NRID","@value":"9000005200561"},{"@type":"NRID","@value":"9000283796262"},{"@type":"NRID","@value":"9000392659971"},{"@type":"NRID","@value":"9000254222525"},{"@type":"NRID","@value":"9000254693923"},{"@type":"NRID","@value":"9000254680460"}],"foaf:name":[{"@language":"en","@value":"SHIMENO HIROSHI"},{"@language":"ja","@value":"占野 廣司"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679138501760","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254222855"}],"foaf:name":[{"@language":"en","@value":"FUKUMOTO YOKO"},{"@language":"ja","@value":"福元 洋子"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679138501634","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000005134666"}],"foaf:name":[{"@language":"en","@value":"FUJI MASAKATSU"},{"@language":"ja","@value":"藤 将勝"}]},{"@id":"https://cir.nii.ac.jp/crid/1030848083296244481","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70078682"},{"@type":"NRID","@value":"1000070078682"},{"@type":"NRID","@value":"9000254219280"},{"@type":"NRID","@value":"9000005134660"},{"@type":"NRID","@value":"9000254686278"},{"@type":"NRID","@value":"9000254222857"},{"@type":"NRID","@value":"9000254686606"},{"@type":"NRID","@value":"9000254231274"},{"@type":"NRID","@value":"9000254691120"},{"@type":"NRID","@value":"9000254213223"},{"@type":"NRID","@value":"9000020069470"},{"@type":"NRID","@value":"9000254235645"},{"@type":"NRID","@value":"9000018016663"},{"@type":"NRID","@value":"9000254222861"},{"@type":"NRID","@value":"9000254222244"},{"@type":"NRID","@value":"9000254225042"},{"@type":"NRID","@value":"9000021844098"},{"@type":"NRID","@value":"9000254671501"},{"@type":"NRID","@value":"9000254218394"},{"@type":"NRID","@value":"9000254691416"},{"@type":"NRID","@value":"9000254223206"},{"@type":"NRID","@value":"9000254222528"},{"@type":"NRID","@value":"9000254693924"},{"@type":"NRID","@value":"9000254686790"},{"@type":"NRID","@value":"9000254680462"}],"foaf:name":[{"@language":"en","@value":"NAGAMATSU ATSUO"},{"@language":"ja","@value":"永松 淳雄"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00092363"},{"@type":"EISSN","@value":"13475223"}],"prism:publicationName":[{"@language":"ja","@value":"ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ"},{"@language":"en","@value":"Chemical and Pharmaceutical Bulletin"},{"@language":"en","@value":"Chem. Pharm. Bull."},{"@language":"en","@value":"CHEMICAL & PHARMACEUTICAL BULLETIN"},{"@language":"ja","@value":"Ｃｈｅｍ．　Ｐｈａｒｍ．　Ｂｕｌｌ．"}],"dc:publisher":[{"@language":"en","@value":"The Pharmaceutical Society of Japan"},{"@language":"ja","@value":"公益社団法人 日本薬学会"}],"prism:publicationDate":"1984","prism:volume":"32","prism:number":"9","prism:startingPage":"3620","prism:endingPage":"3625"},"reviewed":"false","url":[{"@id":"http://www.jstage.jst.go.jp/article/cpb1958/32/9/32_9_3620/_pdf"}],"availableAt":"1984","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=serum%20free%20tryptophan","dc:title":"serum free tryptophan"}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0016991227"},{"@type":"CROSSREF","@value":"10.1248/cpb.32.3620"},{"@type":"PUBMED","@value":"6525656"},{"@type":"CIA","@value":"130003769707"}]}