Synthesis of .ALPHA.,.ALPHA.-Dibromo Esters as Precursors of Ynolates.

  • Shindo Mitsuru
    Institute for Medicinal Resources, University of Tokushima PRESTO, Japan Science and Technology Corporation (JST)
  • Sato Yusuke
    Institute for Medicinal Resources, University of Tokushima
  • Koretsune Ryoko
    Institute for Medicinal Resources, University of Tokushima
  • Yoshikawa Takashi
    Institute for Medicinal Resources, University of Tokushima
  • Matsumoto Kenji
    Institute for Medicinal Resources, University of Tokushima
  • Itoh Kotaro
    PRESTO, Japan Science and Technology Corporation (JST)
  • Shishido Kozo
    Institute for Medicinal Resources, University of Tokushima

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Aliphatic α,α-dibromo esters, precursors of ynolates, were synthesized via bromination of lithium α-bromo ester enolates with 1,2-dibromotetrafluoroethane in good yields. α-Trimethylsilyl-α,α-dibromo esters were synthesized via radical bromination.

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