{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679140366464.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1248/cpb.47.96"}},{"identifier":{"@type":"COI","@value":"1:CAS:528:DyaK1MXmt12iuw%3D%3D"}},{"identifier":{"@type":"PMID","@value":"9987830"}},{"identifier":{"@type":"URI","@value":"http://www.jstage.jst.go.jp/article/cpb1958/47/1/47_1_96/_pdf"}},{"identifier":{"@type":"NAID","@value":"130003947676"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Antiproliferative Constituents from Umbelliferae Plants. V. A New Furanocoumarin and Falcarindiol Furanocoumarin Ethers from the Root of Angelica japonica."}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"The CHCl<SUB>3</SUB> extract of the root of Angelica japonica showed high inhibitory activity against human gastric adenocarcinoma (MK-1) cell growth. From this extract, a new furanocoumarin named japoangelone and four furanocoumarin ethers of falcarindiol, named japoangelols A-D, were isolated together with caffeic acid methyl ester, four polyacetylenic compounds (panaxynol, falcarindiol, 8-O-acetylfalcarindiol, and (9Z)-1, 9-heptadecadiene-4, 6-diyne-3, 8, 11-triol), eight coumarins (osthol, isoimperatorin, scopoletin, byakangelicin, xanthotoxin, bergapten, oxypeucedanin methanolate, and oxypeucedanin hydrate), and two chromones (3'-O-acetylhamaudol, and hamaudol). The structures of the new isolates were determined based on spectral evidence. The ED<SUB>50</SUB> of isolates against MK-1, HeLa, and B16F10 cell lines are reported."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679140366336","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254714687"}],"foaf:name":[{"@language":"en","@value":"FUJIOKA Toshihiro"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679140366465","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254714688"}],"foaf:name":[{"@language":"en","@value":"FURUMI Kazuhiro"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679140366467","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254714689"}],"foaf:name":[{"@language":"en","@value":"FUJII Hiroko"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658434329220","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10078678"},{"@type":"NRID","@value":"1000010078678"},{"@type":"NRID","@value":"9000254714390"},{"@type":"NRID","@value":"9000005232026"},{"@type":"NRID","@value":"9000005208528"},{"@type":"NRID","@value":"9000254714383"},{"@type":"NRID","@value":"9000254337458"},{"@type":"NRID","@value":"9000005129252"},{"@type":"NRID","@value":"9000254714690"},{"@type":"NRID","@value":"9000254715770"},{"@type":"NRID","@value":"9000254241490"},{"@type":"NRID","@value":"9000254708627"},{"@type":"NRID","@value":"9000364924328"},{"@type":"NRID","@value":"9000254717253"},{"@type":"NRID","@value":"9000364942664"},{"@type":"NRID","@value":"9000364941305"},{"@type":"NRID","@value":"9000364942397"},{"@type":"NRID","@value":"9000364942179"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0036872"}],"foaf:name":[{"@language":"en","@value":"OKABE Hikaru"}]},{"@id":"https://cir.nii.ac.jp/crid/1030566608929760774","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60078681"},{"@type":"NRID","@value":"1000060078681"},{"@type":"NRID","@value":"9000005171385"},{"@type":"NRID","@value":"9000254671264"},{"@type":"NRID","@value":"9000254233486"},{"@type":"NRID","@value":"9000254236221"},{"@type":"NRID","@value":"9000259860996"},{"@type":"NRID","@value":"9000014453931"},{"@type":"NRID","@value":"9000254712296"},{"@type":"NRID","@value":"9000254698714"},{"@type":"NRID","@value":"9000397716933"},{"@type":"NRID","@value":"9000014453961"},{"@type":"NRID","@value":"9000254231380"},{"@type":"NRID","@value":"9000397716760"},{"@type":"NRID","@value":"9000397716047"},{"@type":"NRID","@value":"9000254221314"},{"@type":"NRID","@value":"9000254223918"},{"@type":"NRID","@value":"9000254712162"},{"@type":"NRID","@value":"9000254714691"},{"@type":"NRID","@value":"9000254690742"},{"@type":"NRID","@value":"9000254678208"},{"@type":"NRID","@value":"9000254213755"},{"@type":"NRID","@value":"9000254231657"}],"foaf:name":[{"@language":"en","@value":"MIHASHI Kunihide"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679140366340","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254714692"}],"foaf:name":[{"@language":"en","@value":"NAKANO Yukitaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679140366464","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254714693"}],"foaf:name":[{"@language":"en","@value":"MATSUNAGA Hisashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679140366466","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254714694"}],"foaf:name":[{"@language":"en","@value":"KATANO Mitsuo"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679140366337","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254714695"}],"foaf:name":[{"@language":"en","@value":"MORI Masato"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00092363"},{"@type":"EISSN","@value":"13475223"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/00092363"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/00092363"}],"prism:publicationName":[{"@language":"ja","@value":"ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ"},{"@language":"en","@value":"Chemical and Pharmaceutical Bulletin"},{"@language":"en","@value":"Chem. Pharm. Bull."},{"@language":"en","@value":"CHEMICAL & PHARMACEUTICAL BULLETIN"},{"@language":"ja","@value":"Ｃｈｅｍ．　Ｐｈａｒｍ．　Ｂｕｌｌ．"}],"dc:publisher":[{"@language":"en","@value":"The Pharmaceutical Society of Japan"},{"@language":"ja","@value":"公益社団法人 日本薬学会"}],"prism:publicationDate":"1999","prism:volume":"47","prism:number":"1","prism:startingPage":"96","prism:endingPage":"100"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://www.jstage.jst.go.jp/article/cpb1958/47/1/47_1_96/_pdf"}],"availableAt":"1999","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Angelica%20japonica","dc:title":"Angelica japonica"},{"@id":"https://cir.nii.ac.jp/all?q=Umbelliferae","dc:title":"Umbelliferae"},{"@id":"https://cir.nii.ac.jp/all?q=antiproliferative%20constituent","dc:title":"antiproliferative constituent"},{"@id":"https://cir.nii.ac.jp/all?q=furanocoumarin","dc:title":"furanocoumarin"},{"@id":"https://cir.nii.ac.jp/all?q=japoangelol","dc:title":"japoangelol"},{"@id":"https://cir.nii.ac.jp/all?q=falcarindiol%20furanocoumarin%20ethers","dc:title":"falcarindiol furanocoumarin ethers"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360849941004153600","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Metabolomic profiling of Saposhnikoviae Radix from Mongolia by LC–IT–TOF–MS/MS and multivariate statistical analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204163375488","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Antiproliferative Constituents from Umbelliferae Plants. 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