{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679143264384.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1248/cpb.28.1183"}},{"identifier":{"@type":"COI","@value":"1:CAS:528:DyaL3cXktlOguro%3D"}},{"identifier":{"@type":"PMID","@value":"7418110"}},{"identifier":{"@type":"URI","@value":"http://www.jstage.jst.go.jp/article/cpb1958/28/4/28_4_1183/_pdf"}},{"identifier":{"@type":"NAID","@value":"110003662464"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/1981046107"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Anti-inflammatory activities of hederagenin and crude saponin isolated from Sapindus mukorossi GAERTN."}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"The anti-inflammatory activities of hederagenin and crude saponin isolated from Sapindus mukorossi GAERTN were investigated utilizing carrageenin-induced edema, granuloma pouch and adjuvant arthritis in rats. The effects of these agents on vascular permeability and acetic acid-induced writhing in mice were also examined. In some experiments, the results were compared with those obtained with saikogenin A, crude platycodin, platycodigenin and oleanolic acid. Anti-inflammatory activity on carrageenin edema was observed with i. p. and p. o. administered crude saponin, while hederagenin and the other agents used showed activity only when administered i. p. Hederagenin, 100 and 200 mg/kg p. o. per day for 7 days, showed no significant inhibitory effect on granuloma and exudate formations in rats, while crude saponin, 100 and 200 mg/kg p. o., showed significant effects. Crude saponin, 200 mg/kg p. o. per day for 21 days, significantly inhibited the development of hind paw edema associated with adjuvant arthritis in rats, but hederagenin, 50-200 mg/kg p. o., did not. Crude saponin, 400 mg/kg p. o., inhibited the increase in vascular permeability and the number of writhings induced by acetic acid in mice. The results suggest that hederagenin and crude saponin, as well as the other agents used, show some degree of anti-inflammatory activity, especially in the case of saponin."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679143264384","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254684694"}],"foaf:name":[{"@language":"en","@value":"TAKAGI KEIJIRO"},{"@language":"ja","@value":"高木 敬次郎"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679143264386","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254684695"}],"foaf:name":[{"@language":"en","@value":"PARK EUNHEE"},{"@language":"ja","@value":"朴 恩希"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679143264385","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254684696"}],"foaf:name":[{"@language":"en","@value":"KATO HITOSHI"},{"@language":"ja","@value":"加藤 仁"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00092363"},{"@type":"EISSN","@value":"13475223"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/00092363"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/00092363"},{"@type":"NCID","@value":"AA00602100"}],"prism:publicationName":[{"@language":"ja","@value":"ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ"},{"@language":"en","@value":"Chemical and Pharmaceutical Bulletin"},{"@language":"en","@value":"Chem. Pharm. Bull."},{"@language":"en","@value":"CHEMICAL & PHARMACEUTICAL BULLETIN"},{"@language":"ja","@value":"Ｃｈｅｍ．　Ｐｈａｒｍ．　Ｂｕｌｌ．"}],"dc:publisher":[{"@language":"en","@value":"The Pharmaceutical Society of Japan"},{"@language":"ja","@value":"公益社団法人 日本薬学会"}],"prism:publicationDate":"1980","prism:volume":"28","prism:number":"4","prism:startingPage":"1183","prism:endingPage":"1188"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://www.jstage.jst.go.jp/article/cpb1958/28/4/28_4_1183/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/1981046107"}],"availableAt":"1980","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=anti-inflammatory%20activity","dc:title":"anti-inflammatory activity"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001335764654336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Target molecules of food phytochemicals: food science bound for the next dimension."}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206332232192","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"洗浄液中におけるムクロジ果皮の汚染防止効果"},{"@language":"en","@value":"Effects of Mukuroji Pericarp on Deposition of Carbon Black onto Fabrics in Washing Bath"},{"@language":"ja-Kana","@value":"センジョウエキ チュウ ニ オケル ムクロジ カヒ ノ オセン ボウシ コウカ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679144869632","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Anti-platelet Aggregation Triterpene Saponins from the Galls of Sapindus mukorossi"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679430952704","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Physico-Chemical Properties of Monodesmoside Saponins of Sapindaceae(Sapindus mukurossi Gaertn) at Air/Water and Oil/Water Interfaces."}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679602556672","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of SKI306X on Arachidonate Metabolism and Other Inflammatory Mediators"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0018960935"},{"@type":"CROSSREF","@value":"10.1248/cpb.28.1183"},{"@type":"PUBMED","@value":"7418110"},{"@type":"CIA","@value":"110003662464"},{"@type":"OPENAIRE","@value":"doi_dedup___::a987604a4968734b3d253564288aa970"},{"@type":"CROSSREF","@value":"10.1039/c2fo10274a_references_DOI_1zf930JNT5LrOgFQ0iwiwZvrVL"},{"@type":"CROSSREF","@value":"10.3136/fsti9596t9798.2.34_references_DOI_1zf930JNT5LrOgFQ0iwiwZvrVL"},{"@type":"CROSSREF","@value":"10.1248/cpb.55.1412_references_DOI_1zf930JNT5LrOgFQ0iwiwZvrVL"},{"@type":"CROSSREF","@value":"10.1248/bpb.28.1615_references_DOI_1zf930JNT5LrOgFQ0iwiwZvrVL"}]}