{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679145013760.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1248/cpb.27.1715"}},{"identifier":{"@type":"COI","@value":"1:CAS:528:DyaE1MXlvVKlu78%3D"}},{"identifier":{"@type":"PMID","@value":"94276"}},{"identifier":{"@type":"URI","@value":"http://www.jstage.jst.go.jp/article/cpb1958/27/8/27_8_1715/_pdf"}},{"identifier":{"@type":"NAID","@value":"110003623720"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/1980106367"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Antiallergic effects of the adrenergic .BETA.-stimulant trimetoquinol in rats and guinea pigs."},{"@value":"Antiallergic effects of the adrenergic β-stimulant trimetoquinol in rats and guinea pigs"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Trimetoquinol (TMQ), like isoproterenol (Iso), inhibited not only the in vitro anaphylactic release of histamine from minced guinea pig lung tissue but also passive cutaneous anaphylaxis (PCA) in rats and guinea pigs and systemic anaphylaxis in guinea pigs. In these inhibitory effects, TMQ was more potent than Iso and other β-adrenergic stimulants (orciprenaline, salbutamol and terbutaline) in vivo, and 1000 times more active than disodium cromoglycate in vitro. In rat PCA, orally administered TMQ was fully effective as early as 5 min after administration and showed a longer duration of action than Iso. Furthermore, TMQ did not greatly affect the vascular permeability, unlike Iso, which markedly inhibited histamine-induced dye leakage on the rat skin, suggesting that the inhibition of PCA by Iso may be partly ascribed to this action on the capillary vessels, and therefore that the anti-anaphylactic activity of TMQ should be that much greater than that of Iso. When rat mast cells were incubated with TMQ, the cellular level of adenosine-3', 5'-cyclic monophosphate (cAMP) was elevated. The inhibition of in vitro histamine release by TMQ and the elevation of cAMP in the mast cells by TMQ and Iso were both antagonized by propranolol, but not by practolol. These results indicate that TMQ and Iso inhibit the anaphylactic reactions by β-adrenergic mechanisms, probably of a β<SUB>2</SUB>-type."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679145013888","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254217970"}],"foaf:name":[{"@language":"en","@value":"TSUZURAHARA KEI"},{"@language":"ja","@value":"黒葛原 啓"}]},{"@id":"https://cir.nii.ac.jp/crid/1410290696864467328","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254217971"}],"foaf:name":[{"@language":"en","@value":"ONO YASUTOSHI"},{"@language":"ja","@value":"小野 保利"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679145013760","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254217972"}],"foaf:name":[{"@language":"en","@value":"OGIWARA KAZUO"},{"@language":"ja","@value":"荻原 和男"}]},{"@id":"https://cir.nii.ac.jp/crid/1410290696864467330","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254217973"}],"foaf:name":[{"@language":"en","@value":"MURATA TAKASHI"},{"@language":"ja","@value":"村田 隆司"}]},{"@id":"https://cir.nii.ac.jp/crid/1410290696864467329","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254217974"}],"foaf:name":[{"@language":"en","@value":"TAKEYAMA SHIGEYUKI"},{"@language":"ja","@value":"竹山 茂之"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00092363"},{"@type":"EISSN","@value":"13475223"},{"@type":"NCID","@value":"AA00602100"}],"prism:publicationName":[{"@language":"ja","@value":"ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ"},{"@language":"en","@value":"Chemical and Pharmaceutical Bulletin"},{"@language":"en","@value":"Chem. Pharm. Bull."},{"@language":"en","@value":"CHEMICAL & PHARMACEUTICAL BULLETIN"},{"@language":"ja","@value":"Ｃｈｅｍ．　Ｐｈａｒｍ．　Ｂｕｌｌ．"}],"dc:publisher":[{"@language":"en","@value":"The Pharmaceutical Society of Japan"},{"@language":"ja","@value":"公益社団法人 日本薬学会"}],"prism:publicationDate":"1979","prism:volume":"27","prism:number":"8","prism:startingPage":"1715","prism:endingPage":"1724"},"reviewed":"false","url":[{"@id":"http://www.jstage.jst.go.jp/article/cpb1958/27/8/27_8_1715/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/1980106367"}],"availableAt":"1979","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=vascular%20permeability","dc:title":"vascular permeability"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390001204290652672","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Studies on a new antiallergic pyridinecarboxamide TA-5707F and its sodium salt (TA-5707) I. Inhibition of IGE-induced passive cutaneous anaphylaxis (PCA) in rats."},{"@value":"Studies on a New Antiallergic Pyridinecarboxamide TA-5707F and Its Sodium Salt (TA-5707) I. Inhibition of IGE-lnduced Passive Cutaneous Anaphylaxis (PCA) in Rats"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0029436727"},{"@type":"CROSSREF","@value":"10.1248/cpb.27.1715"},{"@type":"PUBMED","@value":"94276"},{"@type":"CIA","@value":"110003623720"},{"@type":"CROSSREF","@value":"10.1254/jjp.40.37_references_DOI_VK1VSl26zOF6EJhySq1fyyrHQ1O"}]}