Triterpenoids from Hippophae rhamnoides L. and Their Nitric Oxide Production-Inhibitory and DPPH Radical-Scavenging Activities

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  • Yang Zhi-Gang
    China National Administration Center for Seabuckthorn Development, Ministry of Water Resources, P. R. China College of Pharmacy, Nihon University
  • Li He-Ran
    College of Pharmacy, Nihon University
  • Wang Li-Yan
    College of Pharmacy, Nihon University
  • Li Yong-Hai
    China National Administration Center for Seabuckthorn Development, Ministry of Water Resources, P. R. China
  • Lu Shun-Guang
    China National Administration Center for Seabuckthorn Development, Ministry of Water Resources, P. R. China
  • Wen Xiu-Feng
    China National Administration Center for Seabuckthorn Development, Ministry of Water Resources, P. R. China
  • Wang Jue
    College of Pharmacy, Nihon University
  • Daikonya Akihiro
    College of Pharmacy, Nihon University
  • Kitanaka Susumu
    College of Pharmacy, Nihon University

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説明

In our investigation on the chemical constituents of Hippophae rhamnoides L., the chloroform-soluble fraction of the 80% acetone extract of branch bark was observed to inhibit nitric oxide (NO) production in a lipopolysaccharide and recombinant mouse interferon-γ-activated murine macrophage-like cell line, RAW 264.7 cells. Two new triterpenoids, 2-O-trans-p-coumaroyl maslinic acid (1) and 2-O-caffeoyl maslinic acid (2), and three known triterpenoids, oleanolic acid (3), 3-O-trans-p-coumaroyl oleanolic acid (4), and 3-O-caffeoyl oleanolic acid (5), and 6-methoxy-2H-1-benzopyran (6) and β-sitosterol (7) were isolated from the branch bark extract. Their inhibitory activities on the production of NO in RAW 264.7 cells and radical-scavenging activities were examined.

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