{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679147614720.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1248/cpb.53.114"}},{"identifier":{"@type":"PMID","@value":"15635244"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"7201049"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/7201049"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I7201049"}},{"identifier":{"@type":"URI","@value":"http://www.jstage.jst.go.jp/article/cpb/53/1/53_1_114/_pdf"}},{"identifier":{"@type":"NAID","@value":"10016651725"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"New Inhibitor against Nuclear Factor of Activated T Cells Transcription from Ribes fasciculatum var. chinense"},{"@value":"New Inhibitor against Nuclear Factor of Activated T Cells Transcription from Ribs fasciculatum var. chinense"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Two new compounds were isolated from the stem and twigs of <i>Ribes fasciculatum</i> var. <i>chinense</i> and their structures were identified to be <i>threo</i>-(7<i>S</i>,8<i>R</i>)-1-(4-hydroxyphenyl)-2-[4-(<i>E</i>)-propenylphenoxy]-propan-1-ol (1), and 5,4′-dihydroxy-7-methoxyflavone-3-<i>O</i>-[α-<small>L</small>-rhamnopyranosyl(1→3)-<i>O</i>-α-<small>L</small>-rhamnopyranosyl(1→6)-<i>O</i>-β-<small>D</small>-glucopyranoside] (2). With nine other known components, they were tested on inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor. Compound 1 showed a potent inhibitory activity (IC<sub>50</sub>=15.6 μ<small>M</small>), while compounds 4, 5 and 9 showed moderate inhibitory activity (IC<sub>50</sub> 22.4, 24.5 and 25.7 μ<small>M</small>, respectively)."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410001204162399878","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000001637706"}],"foaf:name":[{"@language":"en","@value":"Dat Nguyen Tien"}],"jpcoar:affiliationName":[{"@language":"en","@value":"College of Pharmacy, Chungnam National University, Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204162399874","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000001637709"},{"@type":"NRID","@value":"9000021301669"}],"foaf:name":[{"@language":"en","@value":"Cai Xing Fu"}],"jpcoar:affiliationName":[{"@language":"en","@value":"College of Pharmacy, Chungnam National University, Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679147614722","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000001637713"}],"foaf:name":[{"@language":"en","@value":"Shen Quanghai"}],"jpcoar:affiliationName":[{"@language":"en","@value":"College of Pharmacy, Chungnam National University, Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204621844609","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000001637716"}],"foaf:name":[{"@language":"en","@value":"Lee Im Seon"}],"jpcoar:affiliationName":[{"@language":"en","@value":"College of Pharmacy, Chungnam National University, Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679147614723","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Kim Young Ho"}],"jpcoar:affiliationName":[{"@language":"en","@value":"College of Pharmacy, Chungnam National University, Korea"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00092363"},{"@type":"EISSN","@value":"13475223"},{"@type":"NDL_BIB_ID","@value":"000000120512"},{"@type":"ISSN","@value":"00092363"},{"@type":"LISSN","@value":"00092363"},{"@type":"NCID","@value":"AA00602100"}],"prism:publicationName":[{"@language":"ja","@value":"ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ"},{"@language":"en","@value":"Chemical and Pharmaceutical Bulletin"},{"@language":"en","@value":"Chem. Pharm. Bull."},{"@language":"en","@value":"CHEMICAL & PHARMACEUTICAL BULLETIN"},{"@language":"ja","@value":"Ｃｈｅｍ．　Ｐｈａｒｍ．　Ｂｕｌｌ．"}],"dc:publisher":[{"@language":"en","@value":"The Pharmaceutical Society of Japan"},{"@language":"ja","@value":"公益社団法人 日本薬学会"}],"prism:publicationDate":"2005","prism:volume":"53","prism:number":"1","prism:startingPage":"114","prism:endingPage":"117"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/bib/7201049"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I7201049"},{"@id":"http://www.jstage.jst.go.jp/article/cpb/53/1/53_1_114/_pdf"}],"availableAt":"2005","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%3Ci%3ERibes%20fasciculatum%3C/i%3E%20var.%20%3Ci%3Echinense%3C/i%3E","dc:title":"<i>Ribes fasciculatum</i> var. <i>chinense</i>"},{"@id":"https://cir.nii.ac.jp/all?q=Saxifragaceae","dc:title":"Saxifragaceae"},{"@id":"https://cir.nii.ac.jp/all?q=NFAT%20transcription%20factor","dc:title":"NFAT transcription factor"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011144836465920","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dhurrin, (−)-catechin, flavonol glycosides and flavones from Chamaebatia foliolosa"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146468827520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cyclosporin A-sensitive signaling pathway involving calcineurin regulates survival of reactive astrocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620330258176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transcriptional regulation of the IL-2 gene"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621122697088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Isolation and Characterization of Novel Benzoates, Cinnamates, Flavonoids, and Lignans from Riesling Wine and Screening for Antioxidant 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