New Inhibitor against Nuclear Factor of Activated T Cells Transcription from Ribs fasciculatum var. chinense
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- Dat Nguyen Tien
- College of Pharmacy, Chungnam National University, Korea
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- Cai Xing Fu
- College of Pharmacy, Chungnam National University, Korea
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- Shen Quanghai
- College of Pharmacy, Chungnam National University, Korea
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- Lee Im Seon
- College of Pharmacy, Chungnam National University, Korea
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- Kim Young Ho
- College of Pharmacy, Chungnam National University, Korea
書誌事項
- タイトル別名
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- New Inhibitor against Nuclear Factor of Activated T Cells Transcription from Ribes fasciculatum var. chinense
- 公開日
- 2005
- 資源種別
- journal article
- DOI
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- 10.1248/cpb.53.114
- 公開者
- 公益社団法人 日本薬学会
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説明
Two new compounds were isolated from the stem and twigs of Ribes fasciculatum var. chinense and their structures were identified to be threo-(7S,8R)-1-(4-hydroxyphenyl)-2-[4-(E)-propenylphenoxy]-propan-1-ol (1), and 5,4′-dihydroxy-7-methoxyflavone-3-O-[α-L-rhamnopyranosyl(1→3)-O-α-L-rhamnopyranosyl(1→6)-O-β-D-glucopyranoside] (2). With nine other known components, they were tested on inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor. Compound 1 showed a potent inhibitory activity (IC50=15.6 μM), while compounds 4, 5 and 9 showed moderate inhibitory activity (IC50 22.4, 24.5 and 25.7 μM, respectively).
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 53 (1), 114-117, 2005
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679147614720
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- NII論文ID
- 10016651725
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 7201049
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- PubMed
- 15635244
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- NDLサーチ
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
