Annonamine, a New Aporphine Alkaloid from the Leaves of Annona muricata

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  • Matsushige Ayano
    Department of Xenobiotic Metabolism and Molecular Toxicology, Graduate School of Biomedical Sciences, Hiroshima University
  • Kotake Yaichiro
    Department of Xenobiotic Metabolism and Molecular Toxicology, Graduate School of Biomedical Sciences, Hiroshima University
  • Matsunami Katsuyoshi
    Department of Pharmacognosy, Graduate School of Biomedical Sciences, Hiroshima University
  • Otsuka Hideaki
    Department of Pharmacognosy, Graduate School of Biomedical Sciences, Hiroshima University
  • Ohta Shigeru
    Department of Xenobiotic Metabolism and Molecular Toxicology, Graduate School of Biomedical Sciences, Hiroshima University
  • Takeda Yoshio
    Faculty of Pharmacy, Yasuda Women’s University

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Atypical Parkinsonism in the Caribbean Island Guadeloupe is thought to be associated with the consumption of plants of the Annonaceae family, especially Annona muricata (soursop). In this study, a new aporphine alkaloid named annonamine (1) was isolated from the leaves of A. muricata L. together with four known benzylisoquinoline alkaloids (2—5). The structures of the isolated compounds were elucidated by the spectroscopic method.

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