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- Rasyid Faradiba Abdul
- School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University
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- Fukuyoshi Shuichi
- School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University
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- Ando Hirokazu
- School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University
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- Miyake Katsunori
- School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University
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- Atsumi Toshiyuki
- School of Pharmacy, Kyushu University of Health and Welfare
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- Fujie Tetsuo
- Advanced Science Research Center, Kanazawa University
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- Saito Yohei
- School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University
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- Goto Masuo
- UNC Eshelman School of Pharmacy, University of North Carolina
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- Shinya Tomohiro
- School of Pharmacy, Kyushu University of Health and Welfare
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- Mikage Masayuki
- Faculty of Agriculture, Tokyo University of Agriculture
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- Sasaki Yohei
- School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University
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- Nakagawa-Goto Kyoko
- School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University UNC Eshelman School of Pharmacy, University of North Carolina
書誌事項
- タイトル別名
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- A Novel Clerodane Diterpene from <i>Vitex cofassus</i>
この論文をさがす
説明
<p>New clerodane diterpene, 16-hydroxy-pentandralactone (1) and known diterpene acuminolide (2) were isolated from the methanol extract of Vitex cofassus leaves. The chemical structure and the absolute configuration of 1 were determined by MS, NMR and electron circular dichroism (ECD) experiments. The isolated compounds were evaluated for their antiproliferative activities against a panel of human tumor cell lines, including a multidrug-resistant (MDR) cell line. Both compounds showed potent antiproliferative activities against all the tested cell lines with IC50 values of 5.4–11.4 µM. Their effects on cell viability were also tested using vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cells (HUVECs). Compound 1 inhibited VEGF-stimulated HUVEC proliferation in a dose-dependent manner. Based on these results, compound 1 could be a candidate for antitumor agent and inhibitor of angiogenesis.</p>
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 65 (1), 116-120, 2017
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679154530304
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- NII論文ID
- 130005187753
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 027820084
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- PubMed
- 28049908
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可