{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679155144192.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1248/cpb.c16-00682"}},{"identifier":{"@type":"PMID","@value":"27904085"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"027752864"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/027752864"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I027752864"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/cpb/64/12/64_c16-00682/_pdf"}},{"identifier":{"@type":"NAID","@value":"130005170647"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2017193316"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Antiviral Activity and Molecular Geometry of Some New Symmetrical Tris(aminoalkyl)amine Derivatives"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"<p>We report the preparation of new tripodal receptor-type <i>C</i><sub>3</sub>- and <i>C<sub>S</sub></i>-symmetrical molecules constructed on a tris(2-aminoethyl)amine (TAEA) template. Both the anti-herpes simplex virus type 1 (anti-HSV-1) activity and cytotoxic activity of synthesized receptor-type derivatives were evaluated in order to find a characteristic structural feature for these bioactivities of compounds. Among the compounds of synthesized symmetrical TAEA-related derivatives, compound <b>13k</b> showed high anti-HSV-1 activity (50% effective concentration (EC<sub>50</sub>)=16.7 µM) and low cytotoxicity (50% cytotoxic concentration (CC<sub>50</sub>)=>200 µM). The presence of a hydrogen bond donor proton in the molecule is thought to be an important structural factor for expressing potential anti-HSV-1 activities.</p>"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410001204161145347","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000005136078"},{"@type":"NRID","@value":"9000017563019"},{"@type":"NRID","@value":"9000240034774"},{"@type":"NRID","@value":"9000397688027"},{"@type":"NRID","@value":"9000265245975"},{"@type":"NRID","@value":"9000005186076"},{"@type":"NRID","@value":"9000345195390"},{"@type":"NRID","@value":"9000367022509"},{"@type":"NRID","@value":"9000022184943"},{"@type":"NRID","@value":"9000254234221"},{"@type":"NRID","@value":"9000309571681"},{"@type":"NRID","@value":"9000019947571"},{"@type":"KAKEN_RESEARCHERS","@value":"50157583"},{"@type":"NRID","@value":"1000050157583"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0050993"}],"foaf:name":[{"@language":"en","@value":"Mibu Nobuko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Faculty of Pharmaceutical Sciences, Fukuoka University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679155144195","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Yokomizo Kazumi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Faculty of Pharmaceutical Sciences, Sojo University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679155144193","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Murakami Kana"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Faculty of Pharmaceutical Sciences, Fukuoka University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679155144197","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Ono Yurika"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Faculty of Pharmaceutical Sciences, Fukuoka University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679155144198","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Ishimaru Masato"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Faculty of Pharmaceutical Sciences, Fukuoka University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679155144200","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Otsubo Marie"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Faculty of Pharmaceutical Sciences, Fukuoka University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679155144201","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Inao Hiroshi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Faculty of Pharmaceutical Sciences, Sojo University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679155144196","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Ono Yutaro"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Faculty of Pharmaceutical Sciences, Sojo University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679155144192","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Zhou Jian-Rong"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Faculty of Pharmaceutical Sciences, Sojo University"}]},{"@id":"https://cir.nii.ac.jp/crid/1030566608929760771","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00078677"},{"@type":"NRID","@value":"1000000078677"},{"@type":"NRID","@value":"9000020469945"},{"@type":"NRID","@value":"9000395379019"},{"@type":"NRID","@value":"9000265245978"},{"@type":"NRID","@value":"9000324664101"},{"@type":"NRID","@value":"9000367022679"},{"@type":"NRID","@value":"9000382233325"},{"@type":"NRID","@value":"9000326646100"},{"@type":"NRID","@value":"9000367022518"},{"@type":"NRID","@value":"9000309571684"},{"@type":"NRID","@value":"9000019947578"},{"@type":"NRID","@value":"9000255679289"},{"@type":"NRID","@value":"9000255958382"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0074387"}],"foaf:name":[{"@language":"en","@value":"Sumoto Kunihiro"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Faculty of Pharmaceutical Sciences, Fukuoka University"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00092363"},{"@type":"EISSN","@value":"13475223"},{"@type":"NDL_BIB_ID","@value":"000000120512"},{"@type":"ISSN","@value":"00092363"},{"@type":"LISSN","@value":"00092363"},{"@type":"NCID","@value":"AA00602100"}],"prism:publicationName":[{"@language":"ja","@value":"ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ"},{"@language":"en","@value":"Chemical and Pharmaceutical Bulletin"},{"@language":"en","@value":"Chem. Pharm. Bull."},{"@language":"en","@value":"CHEMICAL & PHARMACEUTICAL BULLETIN"},{"@language":"ja","@value":"Ｃｈｅｍ．　Ｐｈａｒｍ．　Ｂｕｌｌ．"}],"dc:publisher":[{"@language":"en","@value":"The Pharmaceutical Society of Japan"},{"@language":"ja","@value":"公益社団法人 日本薬学会"}],"prism:publicationDate":"2016","prism:volume":"64","prism:number":"12","prism:startingPage":"1769","prism:endingPage":"1780"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://id.ndl.go.jp/bib/027752864"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I027752864"},{"@id":"https://www.jstage.jst.go.jp/article/cpb/64/12/64_c16-00682/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2017193316"}],"availableAt":"2016","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=tris(2-aminoethyl)amine","dc:title":"tris(2-aminoethyl)amine"},{"@id":"https://cir.nii.ac.jp/all?q=%3Ci%3EC%3C/i%3E%3Csub%3E3%3C/sub%3E%20symmetry","dc:title":"<i>C</i><sub>3</sub> symmetry"},{"@id":"https://cir.nii.ac.jp/all?q=%3Ci%3EC%3Csub%3ES%3C/sub%3E%3C/i%3E%20symmetry","dc:title":"<i>C<sub>S</sub></i> symmetry"},{"@id":"https://cir.nii.ac.jp/all?q=anti-herpes%20simplex%20virus%20type%201","dc:title":"anti-herpes simplex virus type 1"},{"@id":"https://cir.nii.ac.jp/all?q=tripodal%20receptor-type","dc:title":"tripodal receptor-type"},{"@id":"https://cir.nii.ac.jp/all?q=plaque%20reduction%20assay","dc:title":"plaque reduction assay"},{"@id":"https://cir.nii.ac.jp/all?q=tris(2-aminoethyl)amine","dc:title":"tris(2-aminoethyl)amine"},{"@id":"https://cir.nii.ac.jp/all?q=%3Ci%3EC%3C/i%3E%3Csub%3E3%3C/sub%3E%20symmetry","dc:title":"<i>C</i><sub>3</sub> symmetry"},{"@id":"https://cir.nii.ac.jp/all?q=%3Ci%3EC%3Csub%3ES%3C/sub%3E%3C/i%3E%20symmetry","dc:title":"<i>C<sub>S</sub></i> symmetry"},{"@id":"https://cir.nii.ac.jp/all?q=anti-herpes%20simplex%20virus%20type%201","dc:title":"anti-herpes simplex virus type 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