Role of Norepinephrine in the Lack of Reflex Tachycardia after Angiotensin Converting Enzyme Inhibitor Treatment.
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- YAGI ATSUKO
- Second Department of Internal Medicine, Gunma University School of Medicine
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- ICHIKAWA SHUICHI
- Cardiovascular Hospital of Central Japan
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- SAKAMAKI TETSUO
- Second Department of Internal Medicine, Gunma University School of Medicine
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- ONO ZENPEI
- Second Department of Internal Medicine, Gunma University School of Medicine
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- SATO KUNIO
- Second Department of Internal Medicine, Gunma University School of Medicine
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- NAKAMURA TETSUYA
- Second Department of Internal Medicine, Gunma University School of Medicine
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- MURATA KAZUHIKO
- Second Department of Internal Medicine, Gunma University School of Medicine
説明
YAGI, A., ICHIKAWA, S., SAKAMAKI, T., ONO, Z., SATO, K., NAKAMURA, T. and MURATA, K. Role of Norepinephrine in the Lack of Reflex Tachycardia after Angiotensin Converting Enzyme Inhibitor Treatment. Tohoku J. Exp. Med., 1992, 166 (4), 429-437-Angiotensin converting enzyme inhibitors decrease blood pressure without causing reflex tachycardia in hypertensives, but do not always do so in normotensives. To investigate this phenomenon, hemodynamic changes in normotensive rabbits receiving a subpressor dose of norepinephrine were studied following captopril or diltiazem treatment. We also investigated the effect of captopril on baroreceptor reflex in relation to norepinephrine infusion; the baroreflex sensitivity was determined by the relationship between mean arterial pressure and pulse interval receiving graded doses of phenylephrine. Captopril infusion decreased mean arterial pressure and pulse interval from 84±4 to 74±5 mmHg and 244±7.4 to 216±7.6msec, respectively. In contrast, in rabbits receiving a norepinephrine infusion captopril lowered mean arterial pressure to the same extent (92±5 to 76±3mmHg, p<0.05) without producing reflex tachycardia. When diltiazem was administered, reflex tachycardia occurred in rabbits both with and without a norepinephrine infusion. There was no difference in the baroreflex sensitivity between rabbits receiving norepinephrine with and without captopril treatment. However, the baroreflex curve showed a slight shift to lower pressures after norepinephrine infusion in the rabbits receiving captopril. These results suggest that elevating circulating norepinephrine might be involved in preventing reflex tachycardia after captopril.
収録刊行物
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 166 (4), 429-437, 1992
東北ジャーナル刊行会