{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679220095360.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2152/jmi.60.256"}},{"identifier":{"@type":"COI","@value":"1:STN:280:DC%2BC2c7jtVWksw%3D%3D"}},{"identifier":{"@type":"PMID","@value":"24190044"}},{"identifier":{"@type":"URI","@value":"https://tokushima-u.repo.nii.ac.jp/records/2002525"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/jmi/60/3.4/60_256/_pdf"}},{"identifier":{"@type":"NAID","@value":"130004822691"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2014299049"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Immunohistochemical investigation of the coma blister and its pathogenesis"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"The erythematous patches and vesicles that are observed in coma patients, usually from an overdose of medication, are known as coma blisters. However, it is unknown whether the degenerated sweat gland is a necrosis or apoptosis. We immunohistochemically examined such skin lesions to investigate the characteristics and pathogenesis of the coma blister. Skin lesions were obtained from a forensic autopsy case, a woman in her thirties, of caffeine intoxication. Those lesions were observed in the left femoral, the lower left thigh, and the right knee. Histologically, the skin lesions showed that the keratinocytes had necrosed and the epidermis was thin in some areas. Eccrine sweat gland degeneration was observed. Obvious inflammatory cell infiltrations were not detected. Immunohistochemically, we stained each skin lesion against CD3, CD8, CD45RO, cytokeratin, 70 kD heat shock protein, ubiquitin, 150 kD oxygen regulated protein, and caspase-cleaved keratin 18 neo-epitope M30. They were also stained with an in situ apoptosis detection kit. Degenerated sweat glands featured CD45RO and M30 immunoreactivity. Immunohistochemical staining for CD45RO, CK-L, and M30 might be useful to observe sweat gland degeneration in the coma blister. Therefore, the apoptosis might be related to coma blisters and sweat gland degenerations. J. Med. Invest. 60: 256-261, August, 2013"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326223676672","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70301687"},{"@type":"NRID","@value":"1000070301687"},{"@type":"NRID","@value":"9000001563567"},{"@type":"NRID","@value":"9000318581696"},{"@type":"NRID","@value":"9000009039833"},{"@type":"NRID","@value":"9000397675798"},{"@type":"NRID","@value":"9000402392393"},{"@type":"NRID","@value":"9000283281765"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0163402"}],"foaf:name":[{"@language":"en","@value":"Kashiwagi Masayuki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Forensic Medicine, Faculty of Medicine, Fukuoka University"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751152804736","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60359916"},{"@type":"NRID","@value":"1000060359916"},{"@type":"NRID","@value":"9000345230500"},{"@type":"NRID","@value":"9000020801293"},{"@type":"NRID","@value":"9000003581260"},{"@type":"NRID","@value":"9000409175734"},{"@type":"NRID","@value":"9000347253516"},{"@type":"NRID","@value":"9000257900291"},{"@type":"NRID","@value":"9000283280717"},{"@type":"NRID","@value":"9000283281766"},{"@type":"NRID","@value":"9000004512831"}],"foaf:name":[{"@language":"en","@value":"Ishigami Akiko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Forensic Medicine, Institute of Health Biosciences, the University of Tokushima, Graduate School"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679220095360","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000283281767"}],"foaf:name":[{"@language":"en","@value":"Hara Kenji"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Forensic Medicine, Faculty of Medicine, Fukuoka University"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276177140608","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70309920"},{"@type":"NRID","@value":"1000070309920"},{"@type":"NRID","@value":"9000006807281"},{"@type":"NRID","@value":"9000318581697"},{"@type":"NRID","@value":"9000018243217"},{"@type":"NRID","@value":"9000397675797"},{"@type":"NRID","@value":"9000402392396"},{"@type":"NRID","@value":"9000325463235"},{"@type":"NRID","@value":"9000283281768"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000003315"}],"foaf:name":[{"@language":"en","@value":"Matsusue Aya"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Forensic Medicine, Faculty of Medicine, Fukuoka University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679220095365","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000283281769"}],"foaf:name":[{"@language":"en","@value":"Waters Brian"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Forensic Medicine, Faculty of Medicine, Fukuoka University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679220095366","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000283281770"}],"foaf:name":[{"@language":"en","@value":"Takayama Mio"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Forensic Medicine, Faculty of Medicine, Fukuoka University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679220095364","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000283281771"}],"foaf:name":[{"@language":"en","@value":"Tokunaga Itsuo"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Forensic Medicine, Institute of Health Biosciences, the University of Tokushima, Graduate School"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326211413632","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60283561"},{"@type":"NRID","@value":"1000060283561"},{"@type":"NRID","@value":"9000369738985"},{"@type":"NRID","@value":"9000345230502"},{"@type":"NRID","@value":"9000107393762"},{"@type":"NRID","@value":"9000369739408"},{"@type":"NRID","@value":"9000409175739"},{"@type":"NRID","@value":"9000347253519"},{"@type":"NRID","@value":"9000257900819"},{"@type":"NRID","@value":"9000283281772"}],"foaf:name":[{"@language":"en","@value":"Nishimura Akiyoshi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Forensic Medicine, Institute of Health Biosciences, the University of Tokushima, Graduate School"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658339520007","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10205122"},{"@type":"NRID","@value":"1000010205122"},{"@type":"NRID","@value":"9000004340398"},{"@type":"NRID","@value":"9000347663680"},{"@type":"NRID","@value":"9000008024227"},{"@type":"NRID","@value":"9000107393763"},{"@type":"NRID","@value":"9000006872025"},{"@type":"NRID","@value":"9000318581701"},{"@type":"NRID","@value":"9000017146793"},{"@type":"NRID","@value":"9000017617250"},{"@type":"NRID","@value":"9000005453599"},{"@type":"NRID","@value":"9000403312631"},{"@type":"NRID","@value":"9000018671329"},{"@type":"NRID","@value":"9000347664586"},{"@type":"NRID","@value":"9000254158207"},{"@type":"NRID","@value":"9000398565600"},{"@type":"NRID","@value":"9000397829484"},{"@type":"NRID","@value":"9000335186420"},{"@type":"NRID","@value":"9000402392398"},{"@type":"NRID","@value":"9000257900292"},{"@type":"NRID","@value":"9000004148500"},{"@type":"NRID","@value":"9000283333199"},{"@type":"NRID","@value":"9000310733235"},{"@type":"NRID","@value":"9000002517280"},{"@type":"NRID","@value":"9000283281773"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0172606"}],"foaf:name":[{"@language":"en","@value":"Kubo Shin-ichi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Forensic Medicine, Faculty of Medicine, Fukuoka University"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13431420"},{"@type":"LISSN","@value":"13431420"},{"@type":"EISSN","@value":"13496867"},{"@type":"ISSN","@value":"13431420"},{"@type":"NCID","@value":"AA11166929"}],"prism:publicationName":[{"@language":"en","@value":"The Journal of Medical Investigation"},{"@language":"en","@value":"J. Med. Invest."}],"dc:publisher":[{"@language":"en","@value":"The University of Tokushima Faculty of Medicine"},{"@language":"ja","@value":"国立大学法人　徳島大学医学部"}],"prism:publicationDate":"2013","prism:volume":"60","prism:number":"3.4","prism:startingPage":"256","prism:endingPage":"261"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://tokushima-u.repo.nii.ac.jp/records/2002525"},{"@id":"https://www.jstage.jst.go.jp/article/jmi/60/3.4/60_256/_pdf"},{"@id":"http://repo.lib.tokushima-u.ac.jp/106365"},{"@id":"https://search.jamas.or.jp/link/ui/2014299049"}],"availableAt":"2013","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=coma%20blister","dc:title":"coma blister"},{"@id":"https://cir.nii.ac.jp/all?q=sweat%20gland%20degeneration","dc:title":"sweat gland degeneration"},{"@id":"https://cir.nii.ac.jp/all?q=apoptosis","dc:title":"apoptosis"},{"@id":"https://cir.nii.ac.jp/all?q=intoxication","dc:title":"intoxication"},{"@id":"https://cir.nii.ac.jp/all?q=forensic%20autopsy%20cases","dc:title":"forensic autopsy cases"}],"dcterms:subject":[{"subjectScheme":"Other","notation":[{"@language":"en","@value":"coma blister"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"sweat gland degeneration"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"apoptosis"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"intoxication"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"forensic autopsy cases"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360292619067157632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Occurrence of Bullous Lesions in Acute Barbiturate 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