{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679221384192.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2152/jmi.52.65"}},{"identifier":{"@type":"PMID","@value":"15751275"}},{"identifier":{"@type":"URI","@value":"https://tokushima-u.repo.nii.ac.jp/records/2003955"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/jmi/52/1,2/52_1,2_65/_pdf"}},{"identifier":{"@type":"NAID","@value":"130004465065"}},{"identifier":{"@type":"NAID","@value":"120006378385"}},{"identifier":{"@type":"NAID","@value":"110002253169"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2006150125"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Inhibitory effects of asiatic acid and CPT-11 on growth of HT-29 cells"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Asiatic acid is a pentacyclic triterpene contained in medicinal plants. The cytotoxic effect of this compound and its augmentative effect on the anticancer drug irinotecan hydrochloride (CPT-11) were investigated in the human colon adenocarcinoma cell line HT-29. Asiatic acid dose-dependently showed cytotoxicity in HT-29 cells. DNA fragmentation, annexin-positive apoptotic cells, and caspase-3 activation were observed in a dose-dependent manner. A caspase-3 inhibitor suppressed the DNA ladder formation in a concentration-dependent manner. Bcl-2 and Bcl-x<SUB>L</SUB> proteins were decreased by asiatic acid treatment. These results indicate that asiatic acid induced apoptosis in HT-29 cells via caspase-3 activation. Cytotoxic effects of combined treatment with CPT-11 and asiatic acid on HT-29 cells were further examined. Simultaneous treatment or sequential exposure first to asiatic acid and then to CPT-11 showed an additive effect. Synergism was observed when cells were first exposed to CPT-11 and then to asiatic acid. These results suggest that asiatic acid can be used as an agent for increasing sensitivity of colon cancer cells to treatment with CPT-11 or as an agent for reducing adverse effects of CPT-11. J. Med. Invest. 52: 65-73, February, 2005"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679221384193","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000380126117"},{"@type":"NRID","@value":"9000257899720"}],"foaf:name":[{"@language":"en","@value":"Bunpo Piyawan"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Molecular Bacteriology, Institute of Health Biosciences, The University of Tokushima Graduate School"},{"@language":"en","@value":"Department of Biochemistry, Faculty of Medicine, Chiang Mai University"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326220112640","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40189303"},{"@type":"NRID","@value":"1000040189303"},{"@type":"NRID","@value":"9000003006691"},{"@type":"NRID","@value":"9000414552380"},{"@type":"NRID","@value":"9000376924754"},{"@type":"NRID","@value":"9000370765093"},{"@type":"NRID","@value":"9000003585909"},{"@type":"NRID","@value":"9000253020344"},{"@type":"NRID","@value":"9000006143523"},{"@type":"NRID","@value":"9000283280366"},{"@type":"NRID","@value":"9000380126118"},{"@type":"NRID","@value":"9000257899798"},{"@type":"NRID","@value":"9000331887130"},{"@type":"NRID","@value":"9000253019184"},{"@type":"NRID","@value":"9000255895620"},{"@type":"NRID","@value":"9000414844191"},{"@type":"NRID","@value":"9000345278935"},{"@type":"NRID","@value":"9000253018234"},{"@type":"NRID","@value":"9000318581782"},{"@type":"NRID","@value":"9000283280652"},{"@type":"NRID","@value":"9000256069782"},{"@type":"NRID","@value":"9000283281521"},{"@type":"NRID","@value":"9000257899721"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0054329"}],"foaf:name":[{"@language":"en","@value":"Kataoka Keiko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Molecular Bacteriology, Institute of Health Biosciences, The University of Tokushima Graduate 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Hideki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Molecular Bacteriology, Institute of Health Biosciences, The University of Tokushima Graduate School"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679221384196","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000003195704"},{"@type":"NRID","@value":"9000253020346"},{"@type":"NRID","@value":"9000380126120"},{"@type":"NRID","@value":"9000257899796"},{"@type":"NRID","@value":"9000257899723"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0054333"}],"foaf:name":[{"@language":"en","@value":"Nakayama Haruyuki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Molecular Bacteriology, Institute of Health Biosciences, The University of Tokushima Graduate 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Tomomi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Molecular Bacteriology, Institute of Health Biosciences, The University of Tokushima Graduate School"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679221384195","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000380126122"},{"@type":"NRID","@value":"9000257899725"}],"foaf:name":[{"@language":"en","@value":"Vinitketkumnuen Usanee"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Biochemistry, Faculty of Medicine, Chiang Mai University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679221384194","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000380126123"},{"@type":"NRID","@value":"9000257899726"}],"foaf:name":[{"@language":"en","@value":"Ohnishi Yoshinari"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Molecular Bacteriology, Institute of Health Biosciences, The University of Tokushima Graduate 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Invest."}],"dc:publisher":[{"@language":"en","@value":"The University of Tokushima Faculty of Medicine"},{"@language":"ja","@value":"国立大学法人　徳島大学医学部"}],"prism:publicationDate":"2005","prism:volume":"52","prism:number":"1,2","prism:startingPage":"65","prism:endingPage":"73"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://tokushima-u.repo.nii.ac.jp/records/2003955"},{"@id":"https://www.jstage.jst.go.jp/article/jmi/52/1,2/52_1,2_65/_pdf"},{"@id":"https://repo.lib.tokushima-u.ac.jp/110758"},{"@id":"https://search.jamas.or.jp/link/ui/2006150125"}],"availableAt":"2005","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=asiatic%20acid","dc:title":"asiatic acid"},{"@id":"https://cir.nii.ac.jp/all?q=apoptosis","dc:title":"apoptosis"},{"@id":"https://cir.nii.ac.jp/all?q=CPT-11","dc:title":"CPT-11"},{"@id":"https://cir.nii.ac.jp/all?q=combination","dc:title":"combination"},{"@id":"https://cir.nii.ac.jp/all?q=cytotoxicity","dc:title":"cytotoxicity"}],"dcterms:subject":[{"subjectScheme":"Other","notation":[{"@language":"en","@value":"asiatic acid"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"apoptosis"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"CPT-11"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"combination"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"cytotoxicity"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011143838890496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phase I/II trial of weekly cisplatin, etoposide, and irinotecan chemotherapy for metastatic lung cancer: JCOG 9507"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144034702976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naive patients and patients pretreated with fluorouracil-based chemotherapy."}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144554097536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Enhanced sensitivity to irinotecan by Cdk1 inhibition in the p53-deficient HT29 human colon cancer cell line"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146212901504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mitochondria and Apoptosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619321820800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Apoptosis in anititumor strategies: Modulation of cell cycle or differentiation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619838339456","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Proliferative inhibition, cell-cycle dysregulation, and induction of apoptosis by ursolic acid in human non-small cell lung cancer A549 cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095188254080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Apoptosis of Lung Cancer Cells Caused by Some Anti-cancer Agents (MMC, CPT-11, ADM) is Inhibited by BCL-2"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095544980352","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ursolic acid-induced down-regulation of MMP-9 gene is mediated through the nuclear translocation of glucocorticoid receptor in HT1080 human fibrosarcoma cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095594236672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568522545664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Induction of apoptosis by ursolic acid through activation of caspases and down-regulation of c-IAPs in human prostate epithelial cells."}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570280184576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A phase II irinotecan–cisplatin combination in advanced pancreatic cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045223221504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inhibitory effects of Centella asiatica on azoxymethane-induced aberrant crypt focus formation and carcinogenesis in the intestines of F344 rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518699057024","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Surfing the p53 network"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519659326208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cytotoxic and anti-tumour properties of certain taxa of Umbelliferae with special reference to Centella asiatica (L.) 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