{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679247602176.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1254/fpj.100.67"}},{"identifier":{"@type":"COI","@value":"1:CAS:528:DyaK38XltVChsro%3D"}},{"identifier":{"@type":"PMID","@value":"1644371"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"3789643"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/3789643"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I3789643"}},{"identifier":{"@type":"NAID","@value":"130000760437"}},{"identifier":{"@type":"NAID","@value":"10007370827"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/1994047722"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Effect of SL-1010 (sodium hyaluronate with high molecular weight) on experimental osteoarthritis induced by intra-articularly applied papain in rabbits."},{"@value":"ウサギ膝関節内へのパパイン注入による実験的変形性関節症に対する高分子量ヒアルロン酸ナトリウム（ＳＬ‐１０１０）の効果"},{"@language":"ja-Kana","@value":"ウサギ シツカンセツナイ エ ノ パパイン チュウニュウ ニ ヨル ジッケンテ"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Sodium hyaluronate (HA) with a molecular weight of approximately 600, 000 ?? 1, 200, 000 is, reportedly effective against osteoarthritis (OA). However, since HA with higher molecular weight is expected to be more effective against OA, we investigated the effects of HA (SL-1010) newly produced by fermentation with a molecular weight of 1, 800, 000 ?? 2, 100, 000 on the experimental OA induced by intraarticular injection of papain, into the knee joint of the rabbit, in comparison with those of HA with a molecular weight of about 950, 000 (HA-95). When 0.4, 0.8, and 1.6% papain (0.5ml) was injected into the knee joint of the animal twice with a 3-day interval, there were dose-dependent degenerative changes and a decrease in sulfated glycosaminoglycan (S-GAG) in the articular cartilage with slight synovial inflammatory changes 6 weeks after the final injection of papain. In this OA model, intraarticular application of SL-1010 slightly reduced the degeneration of articular cartilage, compared with the injections of HA-95 or saline (control). SL-1010 also caused a significant recovery in the S-GAG level which was decreased in the cartilage of the OA model, compared with the control. In addition, SL-1010 inhibited the release of <SUP>35</SUP>S-GAG from the cartilage obtained from normal and OA model joints. These results suggest that SL-1010 is effective in inhibiting the degeneration of cartilage in the OA model, probably due to the recovery of the S-GAG level by reducing the release of S-GAG from the cartilage."},{"@value":"分子量約60万～120万のヒアルロン酸ナトリウム(HA)が変形性関節症(OA)に有効であることが報告されているが，さらに分子量の高いHAの方が有効性も高いと考えられるため，新規に発酵法で得られた分子量約180万～210万のHA(SL-1010)の効果をウサギ膝関節内へのパパイン注入により発症したOAモデルを用い検討した．ウサギ膝関節内に3日間隔で2回0.4，0.8および1.6%パパイン溶液0.5mlを注入した場合，用量に依存して軟骨基質の変性，軟骨中の硫酸化グリコサミノグリカン(S-GAG)量の減少が認められ，滑膜の炎症が軽微であるOAモデルが得られた．SL-1010投与群では，このモデルにおける軟骨基質の変性および軟骨細胞数の減少の程度は生理食塩液を投与した対照群および平均分子量約95万のHA(HA-95)投与群に比べやや軽度であった．また，SL-1010投与群ではOAモデルにおいて低下した軟骨中のS-GAG量が対照群と比較し，有意に回復した．さらにSL-1010はウサギの正常関節およびOAモデル関節から採取した軟骨からの<SUP>35</SUP>S-GAGの遊離を抑制する傾向を示した．以上の成績より，SL-1010はウサギを用いたパパイン注入によるOAモデルにおける軟骨変性の抑制に有効であることが示唆された．この作用は，S-GAG遊離を抑制することにより，低下した軟骨中のS-GAG量を回復することが大きく関与しているものと考えられる．"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679247602182","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021220212"}],"foaf:name":[{"@language":"en","@value":"KITOH Yasuhiko"},{"@language":"ja","@value":"鬼頭 康彦"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Hikone Research Laboratories, MARUHO, Co., Ltd."},{"@language":"ja","@value":"マルホ(株)開発本部研究所彦根分室"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679247602180","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021220223"}],"foaf:name":[{"@language":"en","@value":"KATSURAMAKI Tsuneo"},{"@language":"ja","@value":"桂巻 常夫"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Hikone Research Laboratories, MARUHO, Co., Ltd."},{"@language":"ja","@value":"マルホ(株)開発本部研究所彦根分室"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679247602179","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021220228"}],"foaf:name":[{"@language":"en","@value":"TANAKA Hirokazu"},{"@language":"ja","@value":"田中 浩和"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Hikone Research Laboratories, MARUHO, Co., Ltd."},{"@language":"ja","@value":"マルホ(株)開発本部研究所彦根分室"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679247602177","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021220233"}],"foaf:name":[{"@language":"en","@value":"TANAKA Michiko"},{"@language":"ja","@value":"田中 道子"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Hikone Research Laboratories, MARUHO, Co., Ltd."},{"@language":"ja","@value":"マルホ(株)開発本部研究所彦根分室"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679247602183","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021220242"}],"foaf:name":[{"@language":"en","@value":"KITABAYASHI Noriko"},{"@language":"ja","@value":"北林 範子"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Hikone Research Laboratories, MARUHO, Co., Ltd."},{"@language":"ja","@value":"マルホ(株)開発本部研究所彦根分室"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679247602176","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021220259"}],"foaf:name":[{"@language":"en","@value":"UMEMOTO Junji"},{"@language":"ja","@value":"梅本 準治"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Ooyodo Research Laboratories, MARUHO, Co., Ltd."},{"@language":"ja","@value":"マルホ(株)開発本部研究所大淀研究所"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679247602181","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021220265"}],"foaf:name":[{"@language":"en","@value":"NAMBA Kazuhiko"},{"@language":"ja","@value":"難波 和彦"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Hikone Research Laboratories, MARUHO, Co., Ltd."},{"@language":"ja","@value":"マルホ(株)開発本部研究所彦根分室"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679247602184","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021220255"}],"foaf:name":[{"@language":"en","@value":"FUJIMORI Shigeki"},{"@language":"ja","@value":"藤森 茂樹"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"マルホ(株)開発本部研究所彦根分室"},{"@language":"en","@value":"Hikone Research Laboratories, MARUHO, Co., Ltd."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679247602178","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021220248"}],"foaf:name":[{"@language":"en","@value":"KATAOKA Masanori"},{"@language":"ja","@value":"片岡 正憲"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"マルホ(株)開発本部研究所大淀研究所"},{"@language":"en","@value":"Ooyodo Research Laboratories, MARUHO, Co., Ltd."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00155691"},{"@type":"EISSN","@value":"13478397"},{"@type":"NDL_BIB_ID","@value":"000000018989"},{"@type":"ISSN","@value":"00155691"},{"@type":"LISSN","@value":"00155691"},{"@type":"NCID","@value":"AN00198335"}],"prism:publicationName":[{"@language":"en","@value":"Folia Pharmacologica Japonica"},{"@language":"ja","@value":"日本薬理学雑誌"},{"@language":"en","@value":"Folia Pharmacol. Jpn."},{"@language":"ja","@value":"日薬理誌"},{"@language":"en","@value":"Folia Pharmacologica Japonica"},{"@language":"ja","@value":"日本薬理学雑誌"}],"dc:publisher":[{"@language":"en","@value":"The Japanese Pharmacological Society"},{"@language":"ja","@value":"公益社団法人 日本薬理学会"}],"prism:publicationDate":"1992","prism:volume":"100","prism:number":"1","prism:startingPage":"67","prism:endingPage":"76"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/bib/3789643"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I3789643"},{"@id":"https://search.jamas.or.jp/link/ui/1994047722"}],"availableAt":"1992","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390282679684210048","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Clinical Model of Leg Weakness Induced by Intraarticular Administration of Papain in Pigs"},{"@language":"ja","@value":"パパイン関節内投与により誘発した豚脚弱症の臨床モデル"}]},{"@id":"https://cir.nii.ac.jp/crid/1573668924326656256","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"ウサギ膝関節腔内へのCollagenase 注入による実験的変形性膝関節症に対するHyaluronan の作用"},{"@language":"en","@value":"Effect of Hyaluronan on the Experimental Osteoarthritis Induced by Intra-articular Injection of Collagenase in Knee joint of Rabbits"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0007879087"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I3789643"},{"@type":"CROSSREF","@value":"10.1254/fpj.100.67"},{"@type":"PUBMED","@value":"1644371"},{"@type":"CIA","@value":"10007370827"},{"@type":"CIA","@value":"130000760437"},{"@type":"CROSSREF","@value":"10.5938/youton.46.183_references_DOI_UtsQmFFWeLlO44OgV58Q6v1jHtd"}]}