{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679250081024.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1254/fpj.106.41"}},{"identifier":{"@type":"COI","@value":"1:CAS:528:DyaK2MXmslGhsbk%3D"}},{"identifier":{"@type":"PMID","@value":"7590522"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"3633232"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/3633232"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I3633232"}},{"identifier":{"@type":"NAID","@value":"10006060721"}},{"identifier":{"@type":"NAID","@value":"30034987315"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/1996001769"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Anti-atheromatous effects of fenofibrate, a hypolipidemic drug. I. Anti-atheromatous effects are independent of its hypolipidemic effect in cholesterol-fed rabbits."},{"@value":"抗高脂血症薬フェノフィブラートの抗動脈硬化作用　（Ｉ）　コレステロール負荷ウサギにおける血清脂質低下作用を介さない抗動脈硬化作用"},{"@language":"ja-Kana","@value":"コウ コウ シケツショウヤク フェノフィブラート ノ コウ ドウミャク コウカ"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Anti-atheromatous effects of fenofibrate were studied in cholesterol-fed rabbits. Rabbits in the control group (HCD) and fenofibrate group (F-HCD) were fed the 0.5% cholesterol diet and the 0.5% cholesterol plus 0.11 % fenofibrate diet (corresponding to ca. 30 mg/kg/day), respectively, for 2, 4 or 10 weeks. Fenofibrate did not change serum levels of total cholesterol, HDL-choelsterol and triglyceride during the feeding period. The percentage of plaque area (PPA) formation in the thoracic aorta was time-dependently increased. PPA values were reduced in the rabbits treated with fenofibrate for 2 and 4 weeks, but not in those treated for 10 weeks. Fenofibrate had no effect on the plaque thickness. The percentage of circulating free platelets in the HCD group was reduced at the 4th week of feeding, but that in the F-HCD group was not. The anti-platelet effect of fenofibrate might cause the anti-atheromatous effect. Fenofibric acid, an active metabolite of fenofibrate, had no inhibitory effect on LDL peroxidation in vitro. From these results, we conclude that fenofibrate manifests an anti-atheromatous effect independent of the hypolipidemic effect in cholesterol-fed rabbits and that it may inhibit an early event in the atherogenesis."},{"@value":"コレステロール負荷ウサギにおけるフェノフィブラ―トの抗動脈硬化作用を検討した．対照動物には0.5%コレステロール含有食(HCD)を，フェノフィブラート投与動物には0.5%コレステロールおよび0.11%フェノフィブラート(約30mg/kg/dayに相当)含有食を2，4および10週間与えた．フェノフィブラートは血清総コレステロール，高密度リポタンパク(HDL)コレステロールおよびトリグリセライド濃度に影響しなかった．対照群の胸部大動脈の粥状硬化面積%(PPA)は負荷期間とともに高まり，フェノフィブラートは負荷2週および4週においては著明にPPA値を低下させたが，この作用は負荷10週ではみられなかった．また，いずれの時期においてもフェノフィブラートは脂質沈着部位の厚みおよび病理組織像に影響しなかった．フェノフィブラートはHCD負荷による非凝集血小板%の低下を抑制し，フェノフィブラートの抗動脈硬化作用の一部は抗血小板作用に起因する可能性が考えられた．フェノフィブラートの活性代謝物，フェノフィブリン酸はin vitroでの低密度リポタンパクの過酸化を抑制しなかった．以上のように，コレステロール負荷ウサギにおいてフェノフィブラートは血清脂質低下作用に起因しない抗動脈硬化作用を有することが認められた．またこの作用は動脈硬化進展の初期段階の抑制により発現したと考えられた．"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679250081027","@type":"Researcher","foaf:name":[{"@language":"en","@value":"SAITOH Kiyoshi"},{"@language":"ja","@value":"斉藤 清"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"グレラン製薬(株)開発研究センター"},{"@language":"en","@value":"Research Center, Grelan Pharmaceutical Co., Ltd."}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204273369986","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000000438996"}],"foaf:name":[{"@language":"en","@value":"MORI Toshio"},{"@language":"ja","@value":"森 敏男"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"グレラン製薬(株)開発研究センター"},{"@language":"en","@value":"Research Center, Grelan Pharmaceutical Co., Ltd."}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204273369985","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000000438997"}],"foaf:name":[{"@language":"en","@value":"KASAI Hirotaka"},{"@language":"ja","@value":"河西 宏高"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"グレラン製薬(株)開発研究センター"},{"@language":"en","@value":"Research Center, Grelan Pharmaceutical Co., Ltd."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679250081026","@type":"Researcher","foaf:name":[{"@language":"en","@value":"NAGAYAMA Takashi"},{"@language":"ja","@value":"永山 隆"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"グレラン製薬(株)開発研究センター"},{"@language":"en","@value":"Research Center, Grelan Pharmaceutical Co., Ltd."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679250081029","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000000438999"}],"foaf:name":[{"@language":"en","@value":"TSUCHIYA Akiko"},{"@language":"ja","@value":"土屋 亜紀子"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Research Center, Grelan Pharmaceutical Co., Ltd."},{"@language":"ja","@value":"グレラン製薬(株)開発研究センター"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204271086082","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000005270521"}],"foaf:name":[{"@language":"en","@value":"OHBAYASHI Shigeo"},{"@language":"ja","@value":"大林 繁夫"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"グレラン製薬(株)開発研究センター"},{"@language":"en","@value":"Research Center, Grelan Pharmaceutical Co., Ltd."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00155691"},{"@type":"EISSN","@value":"13478397"},{"@type":"NDL_BIB_ID","@value":"000000018989"},{"@type":"ISSN","@value":"00155691"},{"@type":"LISSN","@value":"00155691"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/00155691"},{"@type":"NCID","@value":"AN00198335"}],"prism:publicationName":[{"@language":"en","@value":"Folia Pharmacologica Japonica"},{"@language":"ja","@value":"日本薬理学雑誌"},{"@language":"en","@value":"Folia Pharmacol. Jpn."},{"@language":"ja","@value":"日薬理誌"},{"@language":"en","@value":"Folia Pharmacologica Japonica"},{"@language":"ja","@value":"日本薬理学雑誌"}],"dc:publisher":[{"@language":"en","@value":"The Japanese Pharmacological Society"},{"@language":"ja","@value":"公益社団法人 日本薬理学会"}],"prism:publicationDate":"1995","prism:volume":"106","prism:number":"1","prism:startingPage":"41","prism:endingPage":"50"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/bib/3633232"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I3633232"},{"@id":"https://search.jamas.or.jp/link/ui/1996001769"}],"availableAt":"1995","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011146040932864","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Effect of the acyl-CoA:cholesterol acyltransferase inhibitor, E5324, on experimental atherosclerosis in rabbits"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146261324800","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Effect of clofibrate on plasma lipids of rat and rabbit"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617885506688","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Hyperlipidemic Rabbit Models for Anti-Atherosclerotic Drug Development"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619316615936","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits."}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095948018816","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis."}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468381336320","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia."}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945927758080","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843917697664","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit."}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795738235264","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Effects of fenofibrate on plasma lipoproteins in hypercholesterolemia and combined hyperlipidemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270573584640","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes."}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204270353664","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effect of NIP-200 on hyperlipidemia and atherosclerosis in cholesterol-fed rabbits."},{"@value":"コレステロール負荷ウサギの高脂血症ならびに動脈硬化症に対するＮＩＰ‐２００の作用"},{"@language":"ja-Kana","@value":"コレステロール フカ ウサギ ノ コウ シケツショウ ナラビニ ドウミャク コ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204273369984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Anti-atheromatous effects of fenofibrate, a hypolipidemic drug. II. Anti-atheromatous effects are independent of its hypolipidemic effect in hereditary hyperlipidemic rabbits."},{"@value":"抗高脂血症薬フェノフィブラートの抗動脈硬化作用　（ＩＩ）　遺伝的高脂血症ウサギにおける血清脂質低下作用を介さない抗動脈硬化作用"},{"@language":"ja-Kana","@value":"コウ コウ シケツショウヤク フェノフィブラート ノ コウ ドウミャク コウカ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206433976576","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Combined Effects of Probucol and Bezafibrate on Lipoprotein Metabolism and Liver Cholesteryl Ester Transfer Protein mRNA in Cholesterol-Fed Rabbits"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679265065216","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"HYPOLIPIDEMIC EFFECT OF A NEW ARYLOXY COMPOUND, S-8527, IN EXPERIMENTAL ANIMALS"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679669428224","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"コレステロール食負荷ウサギにおけるsimvastatin (MK-733)の動脈硬化抑制作用"},{"@language":"en","@value":"Anti-atherogenic Effect of Simvastatin (MK-733) in Cholesterol-fed Rabbits"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679810427648","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"EFFECT OF CLINOFIBRATE ON HYPERLIPIDEMIA AND ATHEROSCLEROSIS IN CHOLESTEROL-FED RABBITS"},{"@language":"ja","@value":"コレステロール負荷ウサギの高脂血症ならびに動脈硬化症に対するClinofibrateの作用"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009751736792704","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Preventive effect of MK-733 (Simvastatin), an inhibitor of HMG CoA reductase, on hypercholesterolemia and atherosclerosis induced by cholesterol feeding in rabbits"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291224515795456","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Preservation pf endothelium dependent vascular relaxation in cholesterol-fed rabbit by treatment with the calcium blocker PN200110"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291224515797760","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Dexamethasone-induced suppression of aortic atherosclerosis in cholesterol-fed rabbits, possible mechanism"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291226716429184","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of MK-733 (simvastatin), an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A cholesterol acyltransferase activity in rabbits"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572699492506496","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effect of fibric acid derivatives on blood lipid and lipoprotein levels"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135649445929856","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"フェノフィブラートおよびベザフィブラートの正脂血および高脂血症動物における血清脂質低下作用"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135649445931008","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Inhibition of acyl coenzyme A: cholesterol acyltransferase by 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417124422640000","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"New developments concerning the mode of action of fenofibrate"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698601596102528","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Probucol attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698601596376320","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Toxicity of the HMG-coenzyme A reductase inhibitor, lovastatin, to rabbits"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261548956347136","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Sterol synthesis in vivo in 18 tissues of the squirrel monkey, guinea pig, rabbit, hamster, and rat"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261549352772224","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"日立RPL-42Tローターを用いた微量超遠心分離法によるリポ蛋白コレステロールの測定"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543026060570112","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The protective action of essential oil of onion and garlic in cholesterol-fed rabbits"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543026343901312","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Influence of procetofen on lipid metabolism in normocholesterolemic rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105976013908864","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A new method for the quantitative detection of platelet aggregates in patients with arterial insufficiency"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105976488275200","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"高コレステロール飼料食ウサギの大動脈粥状硬化形成におよぼす4-(4'-chlorobenzyloxy)benzyl nicotinate [KCD-232]の影響"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387449259612416","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Prindopril inhibits both the development of atherosclerosis in the cholesterol-fed rabbit and lipoprotein binding to smooth muscle cells in culture"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387449259613440","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effect of fenofibrate on HMG-CoA reductase activity and LDL receptor expression in rat liver"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387449259614336","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Comparison of CI-976,an ACAT inhibitor, and selected lipid-lowering agents for antiatherosclerotic activity in iliacfemoral and thoracic lesions"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387450990791040","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Atherosclerosis in rabbits identified as high and low responders to an atherogenic diet and the effect of treatment with a β_1-blocker"}]},{"@id":"https://cir.nii.ac.jp/crid/1573668923871156992","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Practical methods for plasma lipoprotein analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1573668924236324480","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Evaluation of the use of serum lanosterol concentration to assess wholebody cholesterol synthesis in rabbits"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950400944179072","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of ciprofibrate and fenofibrate on liver lipids and lipoprotein synthesis in normo-and hyperlipidemic rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950401227635072","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"動脈硬化形成および臓器脂質沈着におよぼす大豆油不ケン化物の影響"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950401408597376","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Experimental pharmacological study of moroxybrate, a hypolipidaemic, antithrombotic, antiathromatous agent"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231874189747200","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Influence of a hyperlipemic drug (Procetofene) on platelet functions and lipid composition in type IIb hyperlipoproteinemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231876390626432","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effect of MK-733 an in hibitor of HMG-CoA reductase, on absorption and excretion of 3H-cholesterol in rabbits."}]},{"@id":"https://cir.nii.ac.jp/crid/1574231876395551872","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Influence of hypocholesteromic drugs on aortic cholesterol esterase in rabbits"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0008167015"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I3633232"},{"@type":"CROSSREF","@value":"10.1254/fpj.106.41"},{"@type":"PUBMED","@value":"7590522"},{"@type":"CIA","@value":"30034987315"},{"@type":"CIA","@value":"10006060721"},{"@type":"CROSSREF","@value":"10.3390/app10238681_references_DOI_6DZ70qXIjxJH52x7zNkN1QDpWHx"},{"@type":"CROSSREF","@value":"10.1253/jcj.63.471_references_DOI_6DZ70qXIjxJH52x7zNkN1QDpWHx"}]}