{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679274948864.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2336/nishinihonhifu.58.237"}},{"identifier":{"@type":"NAID","@value":"10019134704"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/1996185132"}}],"dc:title":[{"@language":"en","@value":"A Case of Proliferating Trichilemmal Tumor with Trichilemmoma."},{"@language":"ja","@value":"外毛根鞘腫を伴った増殖性外毛根鞘性腫よう"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"An 80-year-old man noticed a verrucous tumor on his head. The tumor consisted of a black nodule and a light-red nodule. Histopathologically the former was trichilemmoma (Tr), while the latter was proliferating trichilemmal tumor (PTT). It was uncertain whether or not the PTT was malignant, because the tumor cells were composed of atypical cells and mitotic cells, and the atypical cells were stained positive with anti-proliferating cell nuclear antigen (PCNA) antibody. It is well known that sugarchains of glycoproteins and glycolipids on cell membrane show structural alterations during malignant transformation. Therefore, we immunohistochemically investigated Tr, PTT and normal follicles regarding their lectin-binding characteristics. As a result, apparent differences in the staining properties were found between PTT and the normal follicles, but not between PTT and Tr."},{"@language":"ja","@value":"80歳の男性の頭部に黒色腫瘤と淡紅色腫瘤からなる疣状の腫瘍を認めた。病理組織学的に黒色部は外毛根鞘腫, 淡紅色部は増殖性外毛根鞘性腫瘍であった。増殖性外毛根鞘性腫瘍の腫瘍細胞の中に異型細胞と核分裂像を示す細胞が認められ, 異型細胞は抗PCNA抗体に陽性反応を示し, 悪性化が疑われた。悪性化に伴って細胞膜の糖蛋白や糖脂質の糖鎖構造が変化することが知られているため, 外毛根鞘腫と増殖性外毛根鞘性腫瘍と正常毛包のレクチン結合性を免疫組織化学的に検索した。その結果, 増殖性外毛根鞘性腫瘍と正常毛包の間には染色性に明らかな差異が認められたが, 増殖性外毛根鞘性腫瘍と外毛根鞘腫の間には差異が認められなかった。"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679274948867","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000001936716"}],"foaf:name":[{"@language":"en","@value":"KUBOTA Masaaki"},{"@language":"ja","@value":"窪田 正昭"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Dermatology, Fukui Medical School"},{"@language":"ja","@value":"福井医科大学皮膚科教室"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679274948868","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000004722203"}],"foaf:name":[{"@language":"en","@value":"ISHIGURO Kazumori"},{"@language":"ja","@value":"石黒 和守"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Dermatology, Fukui Medical School"},{"@language":"ja","@value":"福井医科大学皮膚科教室"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204978322052","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000003763124"}],"foaf:name":[{"@language":"en","@value":"YANAGIHARA Makoto"},{"@language":"ja","@value":"柳原 誠"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Dermatology, Fukui Medical School"},{"@language":"ja","@value":"福井医科大学皮膚科教室"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679028442881","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000004509639"}],"foaf:name":[{"@language":"en","@value":"AOYAMA Fumiyo"},{"@language":"ja","@value":"青山 文代"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Dermatology, Aoyama Hifuka"},{"@language":"ja","@value":"青山皮膚科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204335065344","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000003763125"}],"foaf:name":[{"@language":"en","@value":"UEDA Keiichi"},{"@language":"ja","@value":"上田 恵一"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"福井医科大学皮膚科教室"},{"@language":"en","@value":"Department of Dermatology, Fukui Medical School"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03869784"},{"@type":"LISSN","@value":"03869784"},{"@type":"EISSN","@value":"18804047"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/03869784"},{"@type":"NCID","@value":"AN00183881"}],"prism:publicationName":[{"@language":"en","@value":"The Nishinihon Journal of Dermatology"},{"@language":"ja","@value":"西日本皮膚科"},{"@language":"en","@value":"Nishinihon J Dermatol"},{"@language":"en","@value":"Nishi Nihon Hifuka"},{"@language":"ja","@value":"西日皮膚"}],"dc:publisher":[{"@language":"en","@value":"Western Division of Japanese Dermatological Association"},{"@language":"ja","@value":"日本皮膚科学会西部支部"}],"prism:publicationDate":"1996","prism:volume":"58","prism:number":"2","prism:startingPage":"237","prism:endingPage":"240"},"reviewed":"false","url":[{"@id":"https://search.jamas.or.jp/link/ui/1996185132"}],"availableAt":"1996","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Dermatology","dc:title":"Dermatology"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011144443480192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Intergroup Relations"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096018420096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Primary Neoplasms of the Hair Follicle"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420850443264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Local Effect of the Ovary on Implantation in CFE Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844358461824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Polymer modified textile materials. Von J<scp>ERZY</scp> W<scp>YPYCH</scp>. ISBN 0‐471‐83959‐0. New York/Chichester/Brisbane/Toronto/Singapore: John Wiley & Sons 1987. XIII, 317 S., £ 70,00"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268176607104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bibliography"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205738515584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"ヒト皮膚におけるレクチン結合様式の組織化学的研究　第Ⅱ報　外陰Paget病におけるレクチン結合様式の検討"},{"@language":"en","@value":"[Histochemical studies of lectin binding pattern in human skin, II. 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