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Malignant melanoma in a sibling

  • TAGUCHI Shijima
    Department of Dermatology, Graduate School of Comprehensive Human Sciences Medical Sciences for Control of Pathological Processes, University of Tsukuba
  • ISHII Yoshiyuki
    Department of Dermatology, Graduate School of Comprehensive Human Sciences Medical Sciences for Control of Pathological Processes, University of Tsukuba
  • ITO Syusaku
    Department of Dermatology, Hitachi Ltd. General Hospital
  • FUJISAWA Yasuhiro
    Department of Dermatology, Graduate School of Comprehensive Human Sciences Medical Sciences for Control of Pathological Processes, University of Tsukuba
  • TAKAHASHI Takenori
    Department of Dermatology, Graduate School of Comprehensive Human Sciences Medical Sciences for Control of Pathological Processes, University of Tsukuba
  • UMEBAYASHI Yoshihiro
    Department of Dermatology, Akita University School of Medicine
  • KAWACHI Yasuhiro
    Department of Dermatology, Graduate School of Comprehensive Human Sciences Medical Sciences for Control of Pathological Processes, University of Tsukuba
  • OTSUKA Fujio
    Department of Dermatology, Graduate School of Comprehensive Human Sciences Medical Sciences for Control of Pathological Processes, University of Tsukuba

Bibliographic Information

Other Title
  • 悪性黒色腫の姉妹例

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Abstract

A 71-year-old female was referred to our hospital with a 10-year history of a 40×35mm black macule in the left sole. The excised lesion was histologically diagnosed as malignant melanoma with a 0.5mm tumor thickness. Sentinel lymph node biopsy and radiographic examination revealed no evidence of nodal or distant metastasis. The patient's tumor stage was assessed as stage I A (pT1aN0M0) . A month later, her younger sister, who was 68 years old, visited to our hospital with a clinical presentation of a year's history of a black macule in the right big toe. Surgical specimen showed an in situ lesion of melanoma cells. There has been no evidence of recurrence in either case. Familial malignant melanoma in a sibling is rare. To our knowledge, only four family cases were previously reported in Japan. We reported a case of familial malignant melanoma with a few considerations of literature. [Skin Cancer (Japan)2007; 22: 320-324]

Journal

  • Skin Cancer

    Skin Cancer 22 (3), 320-324, 2007

    The Japanese Skin Cancer Society

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