{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679329166336.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3191/thermalmedicine.21.209"}},{"identifier":{"@type":"URI","@value":"http://www.jstage.jst.go.jp/article/thermalmedicine1985/21/4/21_4_209/_pdf"}},{"identifier":{"@type":"NAID","@value":"130003646697"}},{"identifier":{"@type":"NAID","@value":"10029676519"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2006163875"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Induction of Hsp70 in Lymphocytes by Whole Body Far-infrared Hyperthermia"},{"@language":"ja","@value":"遠赤外線温熱治療によるリンパ球におけるHsp70の誘導"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Heat shock proteins function as protein-repairing enzymes for the recovery of stress-damaged cells and defense of cells against many kinds of stress. Therefore, the effects of heat shock protein are expected to play a part in the improvement and recovery of the ability to compete in sports. In the present study, we examined whether whole body hyperthermia at 40°C-42°C for 40 minutes can induce heat shock protein Hsp70 safely and efficiently in human lymphocytes isolated from venous blood in vivo. In addition, to reduce a load of the hyperthermia, we examined the effect of teprenone on the induction of heat shock proteins by hyperthermia of half period.<BR>The relative amount of Hsp70 increased by 2.6-fold (p = 0.051) at 48 h and 2.1-fold (p < 0.05) at 96 h after hyperthermia alone. No significant increase in the relative amount of Hsp70 was observed after the administration of teprenone (600 mg) followed by hyperthermia of half period. Further studies are necessary to evaluate the effect of the administration of teprenone on the induction of heat shock proteins by hyperthermia of half period."},{"@value":"HSP (heat shock protein) には, 予めこれを誘導しておくことで細胞修復作用や生体防御作用が認められ, 大きな侵襲による損傷を抑制することから, スポーツ競技力向上, 回復にその効果が期待される.これらの背景をもとに, ヒトにおいて遠赤外線照射加温により安全に能率よくHsp70が誘導し得るか否かを検討した.さらに加温による負荷を軽減する目的で, テプレノン服用後に遠赤外線照射の加温時間を半分に短縮し, その効果を検討した.<BR>腹・仰臥位をそれぞれ20分間ずつの合計40分間, 40から42℃に遠赤外線照射加温しHsp70の誘導動態を確認した.Hsp70の誘導は, 加温48時問後で2.64倍 (p=0.051), 96時間後で2.07倍 (p<0.05) と有意に増強した.さらに, テプレノン600mg/日の服用の24時間後に加温時間を半分とした遠赤外線照射加温行ったがHsp70の有意な増加は得られなかった."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1030003658340235777","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60065597"},{"@type":"NRID","@value":"1000060065597"},{"@type":"NRID","@value":"9000238953845"},{"@type":"NRID","@value":"9000253500123"},{"@type":"NRID","@value":"9000265264269"},{"@type":"NRID","@value":"9000005341256"},{"@type":"NRID","@value":"9000238886258"},{"@type":"NRID","@value":"9000238929919"},{"@type":"NRID","@value":"9000238926135"},{"@type":"NRID","@value":"9000343347203"},{"@type":"NRID","@value":"9000404789654"},{"@type":"NRID","@value":"9000010085414"},{"@type":"NRID","@value":"9000364163083"},{"@type":"NRID","@value":"9000253500514"},{"@type":"NRID","@value":"9000364817977"},{"@type":"NRID","@value":"9000253500567"},{"@type":"NRID","@value":"9000107321119"},{"@type":"NRID","@value":"9000253499216"},{"@type":"NRID","@value":"9000253500484"},{"@type":"NRID","@value":"9000255814004"},{"@type":"NRID","@value":"9000257772877"},{"@type":"NRID","@value":"9000255814097"},{"@type":"NRID","@value":"9000238890953"},{"@type":"NRID","@value":"9000343347261"},{"@type":"NRID","@value":"9000253501348"},{"@type":"NRID","@value":"9000253499443"},{"@type":"NRID","@value":"9000258035096"},{"@type":"NRID","@value":"9000255814110"},{"@type":"NRID","@value":"9000402926463"},{"@type":"NRID","@value":"9000364824226"},{"@type":"NRID","@value":"9000283102663"},{"@type":"NRID","@value":"9000364163153"},{"@type":"NRID","@value":"9000253501198"},{"@type":"NRID","@value":"9000256373098"},{"@type":"NRID","@value":"9000266885744"},{"@type":"NRID","@value":"9000364825152"},{"@type":"NRID","@value":"9000253499629"},{"@type":"NRID","@value":"9000368410418"},{"@type":"NRID","@value":"9000364818061"},{"@type":"NRID","@value":"9000238954649"},{"@type":"NRID","@value":"9000020321585"},{"@type":"NRID","@value":"9000330326445"},{"@type":"NRID","@value":"9000253501103"},{"@type":"NRID","@value":"9000256376884"},{"@type":"NRID","@value":"9000283246792"},{"@type":"NRID","@value":"9000257182967"},{"@type":"NRID","@value":"9000343347387"},{"@type":"NRID","@value":"9000378086217"},{"@type":"NRID","@value":"9000257772790"},{"@type":"NRID","@value":"9000362191531"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0174809"}],"foaf:name":[{"@language":"en","@value":"ITOH YOUKO"},{"@language":"ja","@value":"伊藤 要子"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Radioisotope Res. 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SHIGEHITO"},{"@language":"ja","@value":"和田 重人"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Dentisty and Oral Surgery, Faculty of Medicine, Toyama Medical and Pharmaceutical University"},{"@language":"ja","@value":"富山医科薬科大学医学部歯科口腔外科学講座"}]},{"@id":"https://cir.nii.ac.jp/crid/1410009222636215943","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000018795273"},{"@type":"NRID","@value":"9000253500571"}],"foaf:name":[{"@language":"en","@value":"FURUYA YUKARI"},{"@language":"ja","@value":"古谷 由香里"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Adult Nursing (Acute Stage), Faculty of Medicine, Toyama Medical and Pharmaceutical University"},{"@language":"ja","@value":"富山医科薬科大学医学部成人看護外科教室"}]},{"@id":"https://cir.nii.ac.jp/crid/1410009222636215939","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000253500572"}],"foaf:name":[{"@language":"en","@value":"YATSUZUKA MIKI"},{"@language":"ja","@value":"八塚 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美穂"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"富山医科薬科大学医学部成人看護外科教室"},{"@language":"en","@value":"Department of Adult Nursing (Acute Stage), Faculty of Medicine, Toyama Medical and Pharmaceutical University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410009222636215940","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000003209068"},{"@type":"NRID","@value":"9000253500575"}],"foaf:name":[{"@language":"en","@value":"OGAWA KOUHEI"},{"@language":"ja","@value":"小川 耕平"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Toyama Prefecture International Health Complex"},{"@language":"ja","@value":"富山県国際健康プラザ"}]},{"@id":"https://cir.nii.ac.jp/crid/1410009222636215936","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000253500576"}],"foaf:name":[{"@language":"en","@value":"TAZAWA KENICHI"},{"@language":"ja","@value":"田澤 賢一"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Second Department of Surgery, Faculty of Medicine, Toyama Medical 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J. Hyperthermic Oncol."},{"@language":"en","@value":"Thermal Medicine"},{"@language":"en","@value":"Thermal Medicine(Japanese Journal of Hyperthermic Oncology)"},{"@language":"ja","@value":"日本ハイパーサーミア誌"},{"@language":"en","@value":"Jpn J Hyperthermic Oncol"},{"@language":"ja","@value":"日本ハイパーサーミア学会誌"}],"dc:publisher":[{"@language":"en","@value":"Japanese Society for Thermal Medicine"},{"@language":"ja","@value":"日本ハイパーサーミア学会"}],"prism:publicationDate":"2005","prism:volume":"21","prism:number":"4","prism:startingPage":"209","prism:endingPage":"220"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://www.jstage.jst.go.jp/article/thermalmedicine1985/21/4/21_4_209/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2006163875"}],"availableAt":"2005","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=far-infrared%20hyperthermia","dc:title":"far-infrared hyperthermia"},{"@id":"https://cir.nii.ac.jp/all?q=heat%20shock%20protein","dc:title":"heat shock protein"},{"@id":"https://cir.nii.ac.jp/all?q=Hsp70","dc:title":"Hsp70"},{"@id":"https://cir.nii.ac.jp/all?q=teprenone","dc:title":"teprenone"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781885758720","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16591233"},{"@type":"JGN","@value":"JP16591233"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16591233/"}],"notation":[{"@language":"ja","@value":"温然トレーニングによるHSP 70の誘導と運動能力向上への挑戦"},{"@language":"en","@value":"Improvement of athletic performances by mild hyperthermic training which included mild hyperthermia in sports training protocol."}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011145226842880","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Long duration mild temperature hyperthermia and brachytherapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520615046912","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Pre-treatment with mild whole-body heating prevents gastric ulcer induced by restraint and water-immersion stress in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420127808256","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Single Oral Dose of Geranylgeranylacetone Induces Heat-Shock Protein 72 and Renders Protection Against Ischemia/Reperfusion Injury in Rat Heart"}]},{"@id":"https://cir.nii.ac.jp/crid/1520853834318011392","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"電熱(赤外放射加熱)"},{"@language":"ja-Kana","@value":"デンネツ セキガイ ホウシャ カネツ"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135650026325248","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Heat stress preconditioning and delayed myocardial protection : what is new?"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980074956453248","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Addition of hyperthermia or cisplatin to radiotherapy for patients with cervical cancer ; two promising combinations-no definite conclusions-"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980074956456576","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Backtable heat-enhanced preconditioning ; a simple and effective means of improving function of heart transplants"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261549933164288","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261549933168512","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Cataneous effects and therapeutic uses of heat with emphasis on infrared radiation"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105974863297792","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Many Mechanisms for Hsp70 protection from cerebral ischemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105974863298944","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"New clinical application of hyperthermia -Preheating therapy-"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105974863299968","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A new quantitative assay of heat shock protein 70 by based on an enzyme-linked immunosorbent assay method"}]},{"@id":"https://cir.nii.ac.jp/crid/1573668924816719872","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Chaperoning signaling pathway ; 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