{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679336192000.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2995/jacsurg.27.28"}},{"identifier":{"@type":"NAID","@value":"10031138859"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2013133827"}}],"dc:title":[{"@language":"en","@value":"A case of recurrent organizing pneumonia after radiation therapy for postoperative breast cancer"},{"@value":"乳癌術後放射線治療後に発症した器質化肺炎の1例"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"We report the case of a 61-year-old female patient with breast cancer who developed recurrent organizing pneumonia outside the radiation field after radiation therapy for postoperative breast cancer. The patient had received tangential radiation therapy and aromatase inhibitors for postoperative breast cancer. Chest computed tomography confirmed an irregular nodule and ground-glass opacities in the left lower lobe outside the radiation field 10 months after radiation therapy. The nodule demonstrated high uptake on 18F-fluorodeoxyglucose positron emission tomography; therefore, lung cancer could not be ruled out. We performed partial resection of the lung, and a diagnosis of organized pneumonia was made on histopathological examination of the resected specimen. Three days after surgery, a chest radiograph revealed an abnormal shadow in the right lower field. The possibility of organizing pneumonia was considered when pulmonary infiltrate did not respond to conventional antibiotic therapy and the patient recovered completely after treatment with steroids. Furthermore, chest CT performed 4 months after surgery revealed consolidation in the right lower lobe. Again, the patient recovered completely with steroid treatment, indicating the possibility of recurrent organizing pneumonia. The number of such reported cases has increased in recent years; however, the etiology remains unclear. In the case presented, aromatase inhibitor therapy combined with radiation therapy may have been the cause of the organizing pneumonia."},{"@value":"乳癌術後に放射線照射を受けた患者で，照射野外に器質化肺炎（organizing pneumonia；OP）を発症した症例を経験した．左乳癌温存術後に放射線照射及びアロマターゼ阻害薬による術後補助療法が施行され，10ヵ月後の胸部CTで照射野外の左肺下葉末梢にスリガラス影を伴った28 mmの辺縁不整な結節影を認めた．炎症所見は正常で，PET-CTで集積を認めたため肺癌を疑い，肺部分切除術を行った．術中迅速診断で器質化肺炎と診断された．術後第3日目の胸部X線で右下肺野に浸潤影を認め，抗菌薬投与するも改善なく，器質化肺炎を疑い副腎皮質ステロイド薬投与を開始し軽快した．また，術後4ヵ月後の胸部CTで対側肺の右下葉に浸潤影が出現し，副腎皮質ステロイド薬投与で陰影は消失．右肺下葉の病変についても器質化肺炎の再発が強く疑われた．近年同様の症例の報告が増加しているが，その発症機序は明かでない．今回放射線療法に併用されたアロマターゼ阻害薬が発症に関与している可能性が示唆された."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410001204754007424","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000006602382"}],"foaf:name":[{"@language":"en","@value":"Hosaka Makoto"},{"@language":"ja","@value":"保坂 誠"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Thoracic Surgery, Suzuka Kaisei Hospital"},{"@language":"ja","@value":"鈴鹿回生病院呼吸器外科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204749492994","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000014488952"}],"foaf:name":[{"@language":"en","@value":"Matsushima Yasushi"},{"@language":"ja","@value":"松島 康"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Thoracic Surgery, Suzuka Kaisei Hospital"},{"@language":"ja","@value":"鈴鹿回生病院呼吸器外科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204754007426","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000018857315"}],"foaf:name":[{"@language":"en","@value":"Ishida Junzo"},{"@language":"ja","@value":"石田 順造"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Thoracic Surgery, Suzuka Kaisei Hospital"},{"@language":"ja","@value":"鈴鹿回生病院呼吸器外科"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09190945"},{"@type":"LISSN","@value":"09190945"},{"@type":"EISSN","@value":"18814158"},{"@type":"NCID","@value":"AN10467885"}],"prism:publicationName":[{"@language":"en","@value":"The Journal of the Japanese Association for Chest Surgery"},{"@language":"ja","@value":"日本呼吸器外科学会雑誌"},{"@language":"en","@value":"Jpn J Chest Surg"},{"@language":"en","@value":"The Journal of the Japanese Associtation for Chest Surgery"},{"@language":"en","@value":"The Journal of the Japanese Association for Chest Surgery"},{"@language":"ja","@value":"日呼外会誌"}],"dc:publisher":[{"@language":"en","@value":"The Japanese Association for Chest Surgery"},{"@language":"ja","@value":"日本呼吸器外科学会"}],"prism:publicationDate":"2013","prism:volume":"27","prism:number":"1","prism:startingPage":"28","prism:endingPage":"32"},"reviewed":"false","url":[{"@id":"https://search.jamas.or.jp/link/ui/2013133827"}],"availableAt":"2013","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E5%99%A8%E8%B3%AA%E5%8C%96%E8%82%BA%E7%82%8E","dc:title":"器質化肺炎"},{"@id":"https://cir.nii.ac.jp/all?q=%E4%B9%B3%E7%99%8C","dc:title":"乳癌"},{"@id":"https://cir.nii.ac.jp/all?q=%E6%94%BE%E5%B0%84%E7%B7%9A%E6%B2%BB%E7%99%82","dc:title":"放射線治療"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%A2%E3%83%AD%E3%83%9E%E3%82%BF%E3%83%BC%E3%82%BC%E9%98%BB%E5%AE%B3%E8%96%AC","dc:title":"アロマターゼ阻害薬"},{"@id":"https://cir.nii.ac.jp/all?q=organizing%20pneumonia","dc:title":"organizing pneumonia"},{"@id":"https://cir.nii.ac.jp/all?q=breast%20cancer","dc:title":"breast cancer"},{"@id":"https://cir.nii.ac.jp/all?q=radiation%20therapy","dc:title":"radiation therapy"},{"@id":"https://cir.nii.ac.jp/all?q=aromatase%20inhibitor","dc:title":"aromatase inhibitor"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050285299902624640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Analysis of Factors Associated With Radiation-Induced Bronchiolitis Obliterans Organizing Pneumonia Syndrome After Breast-Conserving Therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1050862643883620864","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"肺癌術後照射後に発症したbronchiolitis obliterans organizing pneumonia様肺炎の 1 例"},{"@language":"en","@value":"Radiation Pneumonitis Resembling Bronchiolitis Obliterans Organizing Pneumonia after Postoperative Irradiation for Lung Cancer: A case report"},{"@language":"ja-Kana","@value":"ハイガン ジュツゴ ショウシャゴ ニ ハッショウ シタ bronchiolitis obliterans organizing pneumoniaヨウ ハイエン ノ 1レイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094615352192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The clinical characteristics and non-steroidal treatment for radiation-induced bronchiolitis obliterans organizing pneumonia syndrome after breast-conserving therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519841634688","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bronchiolitis Obliterans Organizing Pneumonia Syndrome Primed by Radiation Therapy to the Breast"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994344490368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Focal Organizing Pneumonia on Surgical Lung Biopsy"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418936873728","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Disease activity and 18F-FDG uptake in organising pneumonia: semi-quantitative evaluation using computed tomography and positron emission tomography"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204362015488","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A case of organizing pneumonia with elevation of serum CEA and post operative breast cancer"},{"@language":"ja","@value":"乳癌術後に高ＣＥＡ血症を呈した器質化肺炎の一例"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679824761088","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A CASE OF BRONCHIOLITIS BOLITERANS ORGANIZING PNEUMONIA AFTER CONSERVATIVE TREATMENT OF BREAST CANCER"},{"@language":"ja","@value":"乳房温存療法における放射線治療後に発症したｂｒｏｎｃｈｉｏｌｉｔｉｓ　ｏｂｌｉｔｅｒａｎｓ　ｏｒｇａｎｉｚｉｎｇ　ｐｎｅｕｍｏｎｉａの１例"}]},{"@id":"https://cir.nii.ac.jp/crid/1390586963950930560","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"乳房温存療法に続く放射線治療の51カ月後に再発を確認した器質化肺炎の1例"},{"@language":"en","@value":"A case of organizing pneumonia which recurred 51 months after radiotherapy following breast-conserving surgery"}]},{"@id":"https://cir.nii.ac.jp/crid/1390587903895863808","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"小細胞肺癌に対する放射線治療後に照射野外に発症したBOOPの1例"},{"@language":"en","@value":"Occurrence of BOOP outside Radiation Field after Radiation Therapy for Small Cell Lung Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1523951030970519296","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"研究・症例 肺癌術後の放射線療法後に発症したBOOPの1例"},{"@language":"ja-Kana","@value":"ケンキュウ ・ ショウレイ ハイガン ジュツゴ ノ ホウシャセン リョウホウ ゴ ニ ハッショウ シタ BOOP ノ 1レイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135651363211904","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Analysis of factors associated with radiation-induced bronchiolitis obliterans organizing pneumonia syndrome after breast-conserving therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698601316632960","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Bronchiolitis obliterans organizing pneumonia syndrome primed by radiation therapy to the breast. The Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires (GERM \"O\" P)"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261551270058112","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Focal organizing pneumonia on surgical lung biopsy : causes, clinicoradiologic features, and outcomes"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261551270059392","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Disease activity and ^<18>F-FDG uptake in organising pneumonia: semi-quantitative evaluation using computed tomography and positron emission tomography"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105976200185856","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The clinical characteristics and non-steroidal treatment for radiation-induced broachiolitis obliterans organizing pneumonia syndrome after breast-conserving therapy"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:1001440783"},{"@type":"CROSSREF","@value":"10.2995/jacsurg.27.28"},{"@type":"CIA","@value":"10031138859"}]}