{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679344065792.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.11299/brte.24.185"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"025168104"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/025168104"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I025168104"}},{"identifier":{"@type":"NAID","@value":"130004840203"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2015017058"}}],"dc:title":[{"@language":"en","@value":"Plasma Zinc Disposition in Subjects with Low Zinc Levels Following Administration of Polaprezinc (Zinc L-Carnosine Complex)"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"1.The plasma zinc disposition following administration of polaprezinc (Zinc L-Carnosine Complex) in six male subjects with an initial low serum zinc levels (<70 μg/dL) were compared to those in nineteen subjects with normal zinc levels.<br>2.The plasma zinc concentration reached a maximum plasma concentration (Cmax; 191 ± 30 μg/dL) at 1.83 h and returned to baseline level at 6 h after administration of 75 mg of polaprezinc (containing 17 mg of zinc). The plasma zinc concentration decreased at a half-life of 3.44 h. The area under the curve for plasma concentrations over time (0-12 h after administration; AUC<sub>0-12</sub>) was 1275 ± 138 μg•h<sup>-1</sup>•dL<sup>-1</sup>.<br>3.The plasma zinc level returned to the initial values at 6 h. It then decreased to values lower than those at baseline at 8 and 12 h following administration of polaprezinc.<br>4.In comparison with data from subjects with a normal zinc level, the absorption of zinc in subjects with low serum zinc following administration of polaprezinc was relatively low, and the deviation of AUC<sub>0-12</sub> was minimal."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326216856192","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10200536"},{"@type":"NRID","@value":"1000010200536"},{"@type":"ORCID","@value":"0000-0002-5241-5238"},{"@type":"NRID","@value":"9000001909407"},{"@type":"NRID","@value":"9000243725358"},{"@type":"NRID","@value":"9000000315663"},{"@type":"NRID","@value":"9000403963916"},{"@type":"NRID","@value":"9000345267868"},{"@type":"NRID","@value":"9000397939104"},{"@type":"NRID","@value":"9000006678021"},{"@type":"NRID","@value":"9000410874878"},{"@type":"NRID","@value":"9000255720695"},{"@type":"NRID","@value":"9000408411296"},{"@type":"NRID","@value":"9000362196228"},{"@type":"NRID","@value":"9000018662918"},{"@type":"NRID","@value":"9000018564116"},{"@type":"NRID","@value":"9000402077814"},{"@type":"NRID","@value":"9000283331207"},{"@type":"NRID","@value":"9000369330713"},{"@type":"NRID","@value":"9000253470344"},{"@type":"NRID","@value":"9000010123180"},{"@type":"NRID","@value":"9000404808475"},{"@type":"NRID","@value":"9000395380929"},{"@type":"NRID","@value":"9000018662551"},{"@type":"NRID","@value":"9000411950948"},{"@type":"NRID","@value":"9000396152657"},{"@type":"NRID","@value":"9000241643582"},{"@type":"NRID","@value":"9000021522231"},{"@type":"NRID","@value":"9000386308274"},{"@type":"NRID","@value":"9000411823402"},{"@type":"NRID","@value":"9000018386786"},{"@type":"NRID","@value":"9000253236986"},{"@type":"NRID","@value":"9000413781273"},{"@type":"NRID","@value":"9000401955415"},{"@type":"NRID","@value":"9000253578095"},{"@type":"NRID","@value":"9000409209843"},{"@type":"NRID","@value":"9000283577189"},{"@type":"NRID","@value":"9000256090190"},{"@type":"NRID","@value":"9000257981402"},{"@type":"NRID","@value":"9000009577274"},{"@type":"NRID","@value":"9000399557575"},{"@type":"NRID","@value":"9000375916759"},{"@type":"NRID","@value":"9000019192344"},{"@type":"NRID","@value":"9000253091794"},{"@type":"NRID","@value":"9000399375353"},{"@type":"NRID","@value":"9000018662959"},{"@type":"NRID","@value":"9000241573458"},{"@type":"NRID","@value":"9000402463134"},{"@type":"NRID","@value":"9000406181779"},{"@type":"NRID","@value":"9000020132709"},{"@type":"NRID","@value":"9000253237300"},{"@type":"NRID","@value":"9000253238464"},{"@type":"NRID","@value":"9000412113090"},{"@type":"NRID","@value":"9000401512871"},{"@type":"NRID","@value":"9000401954804"},{"@type":"NRID","@value":"9000415423356"},{"@type":"NRID","@value":"9000398416533"},{"@type":"NRID","@value":"9000398428929"},{"@type":"NRID","@value":"9000319549115"},{"@type":"NRID","@value":"9000410182279"},{"@type":"NRID","@value":"9000317548600"},{"@type":"NRID","@value":"9000398451933"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/yanagisawa0715"}],"foaf:name":[{"@language":"en","@value":"Yanagisawa Hiroyuki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"The Jikei University School of Medicine, Department of Public Health and Environmental Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679344065794","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000283331208"}],"foaf:name":[{"@language":"en","@value":"Kawashima Toru"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Kawashima Stomach and Intestines Department Hospital"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679344065793","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000283331209"}],"foaf:name":[{"@language":"en","@value":"Furuta Sigeru"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Zeria Pharmaceutical Co., Ltd."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679344065795","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000283331210"}],"foaf:name":[{"@language":"en","@value":"Shibasaki Yuji"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Zeria Pharmaceutical Co., Ltd."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679344065796","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000283331211"}],"foaf:name":[{"@language":"en","@value":"Yotsuya Osamu"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Zeria Pharmaceutical Co., Ltd."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0916717X"},{"@type":"LISSN","@value":"0916717X"},{"@type":"EISSN","@value":"18801404"},{"@type":"NDL_BIB_ID","@value":"000000077460"},{"@type":"ISSN","@value":"0916717X"},{"@type":"NCID","@value":"AN10423256"}],"prism:publicationName":[{"@language":"en","@value":"Biomedical Research on Trace Elements"},{"@language":"en","@value":"Biomed. Res. Trace Elements"}],"dc:publisher":[{"@language":"en","@value":"Japan Society for Biomedical Research on Trace Elements"},{"@language":"ja","@value":"一般社団法人 日本微量元素学会"}],"prism:publicationDate":"2013","prism:volume":"24","prism:number":"4","prism:startingPage":"185","prism:endingPage":"189"},"url":[{"@id":"http://id.ndl.go.jp/bib/025168104"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I025168104"},{"@id":"https://search.jamas.or.jp/link/ui/2015017058"}],"availableAt":"2013","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Plasma%20kinetics","dc:title":"Plasma kinetics"},{"@id":"https://cir.nii.ac.jp/all?q=polaprezinc","dc:title":"polaprezinc"},{"@id":"https://cir.nii.ac.jp/all?q=stable%20zinc%20absorption","dc:title":"stable zinc absorption"},{"@id":"https://cir.nii.ac.jp/all?q=taste%20disorder","dc:title":"taste disorder"},{"@id":"https://cir.nii.ac.jp/all?q=low%20zinc%20levels","dc:title":"low zinc levels"}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:1002789799"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I025168104"},{"@type":"CIA","@value":"130004840203"}]}