{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679366270336.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1246/nikkashi.1994.307"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"3865671"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/3865671"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I3865671"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/nikkashi1972/1994/3/1994_3_307/_pdf"}},{"identifier":{"@type":"NAID","@value":"10006669271"}},{"identifier":{"@type":"NAID","@value":"130004060914"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/1995068281"}}],"dc:title":[{"@language":"en","@value":"Physiological Activities of Organic Germanium Compounds Regulation of the Maillard Reaction by Organic Germanium Compounds"},{"@language":"ja","@value":"有機ゲルマニウム化合物の生理活性 有機ゲルマニウム化合物によるMaillard反応の調節"},{"@language":"ja-Kana","@value":"ユウキ ゲルマニウム カゴウブツ ノ セイリ カッセイ ユウキ ゲルマニウム"},{"@value":"Chemistry of Germanium-Characteristics and Similarity as a Group 14 Element. Physiological Activities of Organic Germanium Compounds. Regulation of the Maillard Reaction by Organic Germanium Compounds."}],"description":[{"type":"abstract","notation":[{"@language":"en","@value":"Organic germanium compounds [bis (2-carboxyethylgermanium) trioxide: Ge-132, bis (2-amino-2carboxy-1-phenylethylgermanium) triwdde: Ge-373, bis (2-amino-2-carboxyethylgermanium) trioxide: Ge-385] were found effective in suppressing the formation of Advanced Glycation Endproducts (AGE)from serum proteins, collagen and lens crystallin. We examined the Maillard reaction between amino acids and ribose, and the effects of organic Ge-compounds on the reaction. Ge-compounds did not prevent the formation of Amadori-rearranged substances (ARS), but inhibited further progress toward AGE formation. Specifically, Ge-385 caused the decrease in AGE after incubating the mixtures for longer than 10 days. The mode of action of Ge-compounds in the Maillard reaction was investigated by a NMR to clarify the interaction between glucose and organic Ge-compounds. These compounds could conjugate glucose directly through hydroxyl residues of glucose at the sites 1 and 2. The glucose Gecompound complexes might result in the disconnection of amino-carbonyl products to glucosone and amino residues. Organic germanium compound, specifically Ge-385, which has two amino residues in its one molecule, appears to be much more effective than Ge-132 in the prevention of AGE formation by making carbonyl-NH<SUB>2</SUB>- (Ge-385) conjugates as the substitute of reactive amino residues on functional polypeptides. The effects of organic Ge-compounds were examined in DM-rats induced by streptozotocin (STZ). Both drugs, Ge-132 and 385, were respectively administered to STZ-DM-rats via peroral rout, and clinico-pathological examinations revealed that the formation of glycated serum albumin, serum fructosamine, and cataract (turbidity of lens) were remarkably improved. Ge-compounds are the first candidates that prevent and reversibly solubilize the Maillard products which induce severe clinical complications in patients with diabetes mellitus."},{"@language":"ja","@value":"有機ゲルマニウム化合物,とくにBis(2-carboxyethylgermanium)trioxide[(GeCH<SUB>2</SUB>CH<SUB>2</SUB>COOH)<SUB>2</SUB>O<SUB>3</SUB>,Ge-132],Bis(2-amino-2-carboxy-1-phenylethylgermanium)trioxide[GeCHPhCH(NH<SUB>2</SUB>)COOH<SUB>2</SUB>O<SUB>3</SUB>,Ge-373],Bis(2-amino-2-carboxyethylgermanium)trioxide[GeCH<SUB>2</SUB>CH(NH<SUB>2</SUB>)COOH]<SUB>2</SUB>O<SUB>3</SUB>,Ge385]の生理活性をinvitroモデル実験系および実験動物(糖尿病ラット)に投与して検討した.Ge-373は,DNAを断片化する作用を示した.この事実から,有機ゲルマニウム化合物が糖に対して特殊な作用を発揮するのではないかと考え,MaiUard反応(non-enzymaticamino-carbonylreaction)における効果の検討を行った.種々アミン酸とリボースを混合しAmadori転移およびAdvancedGlycationEndproducts(AGE)の生成を測定する実験系に,Ge-132またはGe-385を加え,AGE形成を蛍光分光光度計により測定した.有機ゲルマニウム化合物は,Amadori転移産物の形成は阻害しなかったが,AGEの形成を抑制した.とくにGe-385は,いったんできたAGEを可逆的に減少させる作用を発揮した.Streptozotocin(STZ)により誘発した糖尿病ラットにGe-132またはGe-385を100mg/kg/d経口投与し,糖尿病合併症に対する効果を観察した.Glycatedalbumin,fructosamineの低下,レンズ混濁の低下が観察された.糖と有機ゲルマニウム化合物,とくにGe-132との相互作用の様子をNuclearMagneticResonance(NMR)を用いて解析した.Ge-132は糖の1および2位のヒドロキシル基と反応し,糖一有機ゲルマニウム複合体を形成することが判明した.この反応がAmadori転移以降の反応を阻害し,AGEの可逆的可溶化を誘導する化学分子論的機序であろうと考えられる."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410851398295282180","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000004102818"},{"@type":"NRID","@value":"9000255709082"}],"foaf:name":[{"@language":"en","@value":"NOMOTO Keiko"},{"@language":"ja","@value":"野元 けい子"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"北里大学医学部分子生物学"},{"@language":"en","@value":"Molecular Biology Laboratory, Kitasato University Schoolof Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1410851398295282176","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000006100171"},{"@type":"NRID","@value":"9000255709081"}],"foaf:name":[{"@language":"en","@value":"NAKAMURA Kunie"},{"@language":"ja","@value":"中村 國衛"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Molecular Biology Laboratory, Kitasato University Schoolof Medicine"},{"@language":"ja","@value":"北里大学医学部分子生物学"}]},{"@id":"https://cir.nii.ac.jp/crid/1410851398295282177","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000003011364"},{"@type":"NRID","@value":"9000255709083"}],"foaf:name":[{"@language":"en","@value":"OSAWA Toshihiko"},{"@language":"ja","@value":"大沢 俊彦"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"名古屋大学農学部食品工業化学"},{"@language":"en","@value":"Department of Food Technology, Faculty of Agriculture, Nagoya University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410851398295282178","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000000514216"},{"@type":"NRID","@value":"9000255709084"}],"foaf:name":[{"@language":"en","@value":"TAKAHASHI Yukio"},{"@language":"ja","@value":"高橋 幸男"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"株式会社浅井ゲルマニウム研究所"},{"@language":"en","@value":"Asai Germanium Institute"}]},{"@id":"https://cir.nii.ac.jp/crid/1410851398295282179","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000004417246"},{"@type":"NRID","@value":"9000255709086"}],"foaf:name":[{"@language":"en","@value":"KAKIMOTO Norihiro"},{"@language":"ja","@value":"柿本 紀博"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"株式会社浅井ゲルマニウム研究所"},{"@language":"en","@value":"Asai Germanium Institute"}]},{"@id":"https://cir.nii.ac.jp/crid/1410851398295282181","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000004417245"},{"@type":"NRID","@value":"9000255709085"}],"foaf:name":[{"@language":"en","@value":"AKIBA Mitsuo"},{"@language":"ja","@value":"秋葉 光雄"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Asai Germanium Institute"},{"@language":"ja","@value":"株式会社浅井ゲルマニウム研究所"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03694577"},{"@type":"EISSN","@value":"21850925"},{"@type":"NDL_BIB_ID","@value":"000000018251"},{"@type":"ISSN","@value":"03694577"},{"@type":"LISSN","@value":"03694577"},{"@type":"NCID","@value":"AN00186595"}],"prism:publicationName":[{"@language":"en","@value":"NIPPON KAGAKU KAISHI"},{"@language":"ja","@value":"日本化学会誌（化学と工業化学）"},{"@language":"en","@value":"Nippon Kagaku Kaishi"},{"@language":"ja","@value":"日化"},{"@language":"en","@value":"NIPPON KAGAKU KAISHI"},{"@language":"ja","@value":"日本化学会誌"}],"dc:publisher":[{"@language":"en","@value":"The Chemical Society of Japan"},{"@language":"ja","@value":"公益社団法人 日本化学会"}],"prism:publicationDate":"1994-03-10","prism:volume":"1994","prism:number":"3","prism:startingPage":"307","prism:endingPage":"316"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/bib/3865671"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I3865671"},{"@id":"https://www.jstage.jst.go.jp/article/nikkashi1972/1994/3/1994_3_307/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/1995068281"}],"availableAt":"1994-03-10","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=General%20Chemistry","dc:title":"General Chemistry"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1570854174510059264","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1571135649486766336","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1573668924277166080","@type":"Article","relationType":["cites"]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0002550294"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I3865671"},{"@type":"CROSSREF","@value":"10.1246/nikkashi.1994.307"},{"@type":"CIA","@value":"10006669271"},{"@type":"CIA","@value":"130004060914"}]}