{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679388769920.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2329/perio.50.231"}},{"identifier":{"@type":"NAID","@value":"10027095159"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2008231952"}}],"dc:title":[{"@language":"en","@value":"Effects of Xylitol-Containing Chewing Gum on Plaque Formation and Salivary Components"},{"@language":"ja","@value":"キシリトール含有ガム摂取によるプラーク形成および唾液成分に及ぼす影響"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"The aim of the present study was to investigate the effects of xylitol-containing chewing gum on plaque formation and composition of the saliva. Seven subjects (mean age 31.3±8.5) with apparently healthy gingival, with no evidence of periodontal disease, were enrolled in this study. This study was designed as a single-blind, cross-over, clinical trial. It included one test period (3 days) and one control period (3 days), with a 2-day washout period. At the beginning of each period during the three-day experimental period, the participants were told to abstain from using all mechanical plaque control measures. During the test period, the subjects were instructed to chew 2 pieces of xylitol gum for five minutes, three times a day. At the beginning and the end of each period, the dental plaque formation was scored using the Quigley & Hein plaque index (QHI), and the salivary composition (content, pH, LDH, ALP, F-Hb, <I>S.mutans</I>) was examined. The results revealed that during the test period, the QHI score increased by 1.08±0.08, whereas during the control period, it increased by 1.52±0.23. Thus, the increase in the QHI score was significantly greater (p<0.05) during the test period than during the control period. There were no significant differences in the salivary composition among the groups.<BR>Nihon Shishubyo Gakkai Kaishi (J Jpn Soc Periodontol) 50(4) : 231-237, 2008."},{"@language":"ja","@value":"今回キシリトール含有ガム摂取の効果を臨床的, 細菌学的, 生化学的見地から検討した。被験者は臨床的に歯周炎の徴候がなく, 実験開始前の少なくとも3ヵ月以内に抗生物質を使用していない7名(平均年齢31.3±8.5歳)を対象とし, またすべての被験者は非喫煙者とした。実験はsingle-blind, cross-over designにて行われた。実験開始後3日間すべての被験者に口腔清掃を禁じ(trial 1), 次の2日間はwashout periodとして口腔清掃を再開させたのち, さらに3日間口腔清掃を禁じ(trial 2), キシリトール含有ガムをtrial 1もしくはtrial 2のどちらかの期間に摂取させた。このときtrial 1もしくはtrial 2で, キシリトール含有ガムを摂取した時期をキシリトール期, しなかった時期をコントロール期とした。trial 1,2のそれぞれ開始時および終了時に臨床パラメータとしてQHIを, 唾液検査項目として唾液量および唾液pH, LDH, ALP, F-Hb, <I>S.mutans</I>菌数を測定し, コントロール期とキシリトール期それぞれのday 0からday 3にかけての変化量を計算し, 各パラメータを統計処理した。キシリトール期はQHIスコア増加量が1.08±0.08となり, コントロール期の増加量が1.52±0.23と比較し統計学的有意差が認められた。唾液検査に関してはコントロール期, キシリトール期の両期間について統計学的有意差は認められなかった。<BR>日本歯周病学会会誌(日歯周誌)50(4) : 231-237, 2008"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410290696587468290","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000018193170"}],"foaf:name":[{"@language":"en","@value":"Sato Hirokazu"},{"@language":"ja","@value":"佐藤 宏和"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Periodontology The Nippon Dental University, School of Life Dentistry at Tokyo"},{"@language":"ja","@value":"日本歯科大学生命歯学部歯周病学講座"}]},{"@id":"https://cir.nii.ac.jp/crid/1410290696587468289","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Ito Hiroshi"},{"@language":"ja","@value":"伊藤 弘"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Periodontology The Nippon Dental University, School of Life Dentistry at Tokyo"},{"@language":"ja","@value":"日本歯科大学生命歯学部歯周病学講座"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751139659264","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40409222"},{"@type":"NRID","@value":"1000040409222"},{"@type":"NRID","@value":"9000391505100"},{"@type":"NRID","@value":"9000258314447"},{"@type":"NRID","@value":"9000258290806"},{"@type":"NRID","@value":"9000258316111"},{"@type":"NRID","@value":"9000258312041"},{"@type":"NRID","@value":"9000283734782"},{"@type":"NRID","@value":"9000345276456"},{"@type":"NRID","@value":"9000283733207"},{"@type":"NRID","@value":"9000242387365"},{"@type":"NRID","@value":"9000258311478"},{"@type":"NRID","@value":"9000283734199"},{"@type":"NRID","@value":"9000258313239"},{"@type":"NRID","@value":"9000258314738"},{"@type":"NRID","@value":"9000368417536"},{"@type":"NRID","@value":"9000283735453"},{"@type":"NRID","@value":"9000309577802"},{"@type":"NRID","@value":"9000283733537"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/satoetsu"}],"foaf:name":[{"@language":"en","@value":"Murakashi Etsuko"},{"@language":"ja","@value":"村樫 悦子"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Periodontology The Nippon Dental University, School of Life Dentistry at Tokyo"},{"@language":"ja","@value":"日本歯科大学生命歯学部歯周病学講座"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204413393664","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000005787859"}],"foaf:name":[{"@language":"en","@value":"Sekino Satoshi"},{"@language":"ja","@value":"関野 愉"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"日本歯科大学生命歯学部歯周病学講座"},{"@language":"en","@value":"Department of Periodontology The Nippon Dental University, School of Life Dentistry at Tokyo"}]},{"@id":"https://cir.nii.ac.jp/crid/1410290696587468416","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Numabe Yukihiro"},{"@language":"ja","@value":"沼部 幸博"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Periodontology The Nippon Dental University, School of Life Dentistry at Tokyo"},{"@language":"ja","@value":"日本歯科大学生命歯学部歯周病学講座"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03850110"},{"@type":"LISSN","@value":"03850110"},{"@type":"EISSN","@value":"1880408X"},{"@type":"NCID","@value":"AN0019129X"}],"prism:publicationName":[{"@language":"en","@value":"Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology)"},{"@language":"ja","@value":"日本歯周病学会会誌"},{"@language":"en","@value":"Nihon Shishubyo Gakkai Kaishi"},{"@language":"en","@value":"Journal of the Japanese Society of Periodontology"},{"@language":"en","@value":"J. Jpn. Soc. Periodontol."},{"@language":"ja","@value":"日歯周誌"},{"@language":"en","@value":"J Jpn Soc Periodontol"}],"dc:publisher":[{"@language":"en","@value":"JAPANESE SOCIETY OF PERIODONTOLOGY"},{"@language":"ja","@value":"特定非営利活動法人 日本歯周病学会"}],"prism:publicationDate":"2008","prism:volume":"50","prism:number":"4","prism:startingPage":"231","prism:endingPage":"237"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://search.jamas.or.jp/link/ui/2008231952"}],"availableAt":"2008","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=xylitol","dc:title":"xylitol"},{"@id":"https://cir.nii.ac.jp/all?q=preventive%20periodontitis","dc:title":"preventive periodontitis"},{"@id":"https://cir.nii.ac.jp/all?q=salivary%20composition","dc:title":"salivary composition"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%AD%E3%82%B7%E3%83%AA%E3%83%88%E3%83%BC%E3%83%AB","dc:title":"キシリトール"},{"@id":"https://cir.nii.ac.jp/all?q=%E6%AD%AF%E5%91%A8%E7%97%85%E4%BA%88%E9%98%B2","dc:title":"歯周病予防"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%94%BE%E6%B6%B2%E6%88%90%E5%88%86","dc:title":"唾液成分"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011145296430720","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"The effect of xylitol and chlorhexidine acetate/xylitol chewing gums on plaque accumulation and gingival inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619749116544","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Spotlight"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093965074944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Use of Chlorhexidine Chewing Gum Significantly Reduces Dental Plaque Formation Compared to Use of Similar Xylitol and Sorbitol Products"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095653698432","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mutans Streptococci Dose Response to Xylitol Chewing Gum"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846640371043200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effects of xylitol on the femur and mandibular bone in ovariectomized rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570157282944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Six-month polyol chewing-gum programme in kindergarten-age children: a feasibility study focusing on mutans streptococci and dental plaque"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518488031872","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of Xylitol and Sorbitol in Chewing-Gums on Mutans Streptococci, Plaque pH and Mineral Loss of Enamel"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520008557440","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Effect of a xylitol chewing gum on plaque quantity and quality"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945495076608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Xylitol Concentration in Saliva and Dental Plaque after Use of Various Xylitol-Containing Products"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945508900992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Long-Term Effect of Xylitol Gum Use on Mutans Streptococci in Adults"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844082834944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dental plaque formation and salivary mutans streptococci in schoolchildren after use of xylitol‐containing chewing gum"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320255334272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"New insights into salivary lactate dehydrogenase of human subjects"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268716513152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Properties of Whole Saliva and Dental Plaque in Relation to 40-Month Consumption of Chewing Gums Containing Xylitol, Sorbitol or Sucrose"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268829396992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Composite restorative resins: Composition versus wall-to-wall polymerization contraction"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269189283328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Thirty-nine-month xylitol chewing-gum programme in initially 8-year-old school children: a feasibility study focusing on mutans streptococci and lactobacilli"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204413393664","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Inhibitory Effect of Xylitol on de novo Plaque Formation."},{"@value":"キシリトールのプラーク沈着抑制効果に関する研究"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291226300747136","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Properties of whole saliva and dental plaque in relation to 40-month consumption of chewing gums containing xylitol, sorbitol, of sucrose"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291226300751104","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Xylitol の Streptococccus mutans 菌体付着, 不溶性 glucan 生成への影響及び代謝適応性"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854175236037504","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Mutans Streptococci Dose Response to Xylitol Chewing Gum"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135651230883072","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Remineralizing potential, antiplaque and antigingivitis effects of xylitol and sorbitol sweetened chewing gum"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135651230884224","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Long-term effect of xylitol gum use on mutans streptococci in adults"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417126207591552","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Use of chlorhexidine chewing gum significantly reduces dental plaque formation compared to use of similar xylitol and sorbitol products"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417126207592576","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"唾液を検体とする歯周病検査の意義"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698601184302848","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Xylitol-, sorbitol-, fructose- and sucrose-induced physico-chemical changes in saliva"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698601184304000","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"唾液生化学検査における基準値設定のための解析"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261550390636416","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"歯周病のスクリーニングテストの開発 : 唾液を用いた生化学検査について"},{"@language":"en","@value":"Study on the Items of Biochemical Examinations for Periodontal Disease : Its Application for Screening Test"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261551137729024","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effect of xylitol-containing chewing gums on lactic acid production in dental plaque from caries active pre-school children"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824501091145600","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Chewing gum and dental health. Literature review"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824501091146752","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Xylitol concentration in saliva and dental plaque after use of various xylitol-containing products"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105976067854080","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effect of xylitol and sorbitol in chewing-gums on mutans streptococci, plaque pH and mineral loss of enamel"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105976067855360","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Six-month polyol chewing-gum programme in kindergarten-age children : a feasibility study focusing on mutans streptococci and dental plaque"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950400409094784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"唾液の乳酸脱水素酵素の検討"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950400997992448","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Thirty-nine-month xylitol chewing-gum programme in initially 8-year-old school children : a feasibility study focusing on mutans streptococci and lactobacilli"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231875974697472","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"New insights into salivary lactate dehydrogenase of human subjects"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231875974698624","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Dental plaque formation and salivary mutans streptococci in schoolchildren after use of xylitol-containig chewing gum"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231875974702336","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Three clinical trials comparing xylitol- and sorbitol-containing chewing gums for their effect on supragingival plaque accumulation"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0032623242"},{"@type":"CROSSREF","@value":"10.2329/perio.50.231"},{"@type":"CIA","@value":"10027095159"},{"@type":"OPENAIRE","@value":"doi_dedup___::467de778facabb9fee7a5c8586a1d860"},{"@type":"CROSSREF","@value":"10.1007/s11282-011-0079-4_references_DOI_Uq4cp8ij6eyXwQngpphuIHJiqnq"}]}