{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679391728512.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1293/tox.11.197"}},{"identifier":{"@type":"COI","@value":"1:CAS:528:DyaK1cXnsVSqtrs%3D"}},{"identifier":{"@type":"URI","@value":"http://www.jstage.jst.go.jp/article/tox/11/3/11_3_197/_pdf"}},{"identifier":{"@type":"NAID","@value":"10019086088"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/1999067558"}}],"dc:title":[{"@language":"en","@value":"Effects of Neonatal Administration of Monosodium Glutamate on Bone in Rats."}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"It has been known that monosodium glutamate (MSG) treatment to neonatal rodents affects hypothalamic arcuate nucleus, the primary site of growth hormone releasing hormone, and consequently inhibits growth hormone release. However, there have been few reports on bone changes with aging after MSG treatment to neonatal rodents. Male and female neonatal F344 rats were subcutaneously given 4,000 mg/kg of MSG on days 0, 2, 4, 6, and 8 after birth, and the changes of the femurs were examined at 12 months of age. As a result, the bone length, diameters of the femur diaphysis and bone mineral density, especially the metaphysis region, were decreased by the treatment. Histologically, the amount of trabecular bone in the epiphysis and metaphysis regions also decreased in MSG-treated rats, together with an increase of adipose tissue in the bone marrow."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410001204414586897","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000003099538"},{"@type":"NRID","@value":"9000253284947"},{"@type":"NRID","@value":"9000253284325"}],"foaf:name":[{"@language":"en","@value":"Teranishi Munehiro"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Laboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679391728514","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000001932980"}],"foaf:name":[{"@language":"en","@value":"Makino Toshihiko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Laboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679391728512","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Yamoto Takashi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Laboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd."}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204416269700","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000005632129"}],"foaf:name":[{"@language":"en","@value":"Takaoka Masaya"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Laboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd."}]},{"@id":"https://cir.nii.ac.jp/crid/1410001206426180356","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000005632134"},{"@type":"NRID","@value":"9000253284948"},{"@type":"NRID","@value":"9000253284323"}],"foaf:name":[{"@language":"en","@value":"Manabe Sunao"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Laboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09149198"},{"@type":"EISSN","@value":"1881915X"},{"@type":"NCID","@value":"AA12022786"}],"prism:publicationName":[{"@language":"en","@value":"Journal of Toxicologic Pathology"},{"@language":"ja","@value":"Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃ　Ｐａｔｈｏｌｏｇｙ"},{"@language":"en","@value":"J Toxicol Pathol"},{"@language":"ja","@value":"Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃ　Ｐａｔｈｏｌｏｇｙ"}],"dc:publisher":[{"@language":"en","@value":"JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY"},{"@language":"ja","@value":"日本毒性病理学会"}],"prism:publicationDate":"1998","prism:volume":"11","prism:number":"3","prism:startingPage":"197","prism:endingPage":"201"},"reviewed":"false","url":[{"@id":"http://www.jstage.jst.go.jp/article/tox/11/3/11_3_197/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/1999067558"}],"availableAt":"1998","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Monosodium%20L-Glutamate","dc:title":"Monosodium L-Glutamate"},{"@id":"https://cir.nii.ac.jp/all?q=Rat","dc:title":"Rat"},{"@id":"https://cir.nii.ac.jp/all?q=Bone","dc:title":"Bone"},{"@id":"https://cir.nii.ac.jp/all?q=Bone%20Mineral%20Density","dc:title":"Bone Mineral Density"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1361137044548146944","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Effect of Monosodium Glutamate on Some Endocrine Functions"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996123034624","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"The ovariectomized rat model of postmenopausal bone loss"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469544196480","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium 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Rat?"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896326114048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Opposite effects of insulin-like growth factor-I on the formation of trabecular and cortical bone in adult female rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318721070976","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Models of Neuroendocrine Regulation: Use of Monosodium Glutamate as an Investigational Tool"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319504087168","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Late Endocrine Effects of Administering Monosodium Glutamate to Neonatal Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670321032684288","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Marked Reduction in Gonadal Steroid Hormone Levels in Rats Treated Neonatally with Monosodium <i>L</i>-Glutamate: Further Evidence for Disruption of Hypothalamic-Pituitary-Gonadal Axis Regulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951796062396160","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"GLUTAMATE—INDUCED RETINAL DEGENERATION IN NEONATAL MICE. ELECTRON MICROSCOPY OF THE ACUTELY EVOLVING LESION"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270584152064","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Growth Hormone-Releasing Hormone Depletion in the Female Rat: Similarities to Aging"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270992108032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Analysis of the Disruption in Hypothalamic-Pituitary Regulation in Rats Treated Neonatally with Monosodium L-Glutamate (MSG): Evidence for the Involvement of Tuberoinfundibular Cholinergic and Dopaminergic Systems in Neuroendocrine Regulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204414586880","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Comparison of Bone Changes between Neonatally Monosodium Glutamate-Treated Rats and Mini Rats."}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204415544192","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Comparative Bone Morphometry between Mini Rats and Wistar Rats."}]},{"@id":"https://cir.nii.ac.jp/crid/1570009750540460416","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Glutamate-induced retinal degeneration in neonatal mice. Electron microscopy of the acutely evolving lesions"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572700493621888","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effect of monosodium glutamate on the histogenesis of bone and bone marrow in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572700493883008","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Analysis of the disruption in hypothalamic-pituitary regulation in rats treated neonatally with monosodium L-glutamate (MSG). Evidence for the involvement of tuberoinfundibular cholinergic and dopaminergic systems in neuroendocrine regulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854176690936064","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Is glutamate-induced reduction in growth hormone-releasing hormone a neuroendocrine model of aging in the rat?"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698600400463488","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Opposite effects of insulin-like growth factor-I on the formation of trabecular and cortical bone in adult female rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824500307567488","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Glutamate-induced neuronal necrosis in the infant mouse hypothalamus"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387450260987648","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Skeletal system"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950400214409472","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Growth hormone-releasing hormone depletion in the female rat : similarities to aging"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0008664859"},{"@type":"CROSSREF","@value":"10.1293/tox.11.197"},{"@type":"CIA","@value":"10019086088"},{"@type":"CROSSREF","@value":"10.1293/tox.12.119_references_DOI_7jlgc3cOcGFYojbmkw6RfySA7IY"},{"@type":"CROSSREF","@value":"10.1293/tox.12.183_references_DOI_7jlgc3cOcGFYojbmkw6RfySA7IY"}]}