{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679407359744.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.5551/jat.13.68"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/jat/13/1/13_1_68/_pdf"}},{"identifier":{"@type":"PMID","@value":"16505594"}},{"identifier":{"@type":"NAID","@value":"130006827159"}},{"identifier":{"@type":"NAID","@value":"10020628037"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2007003370"}}],"dc:title":[{"@language":"en","@value":"Probucol and Atorvastatin Decrease Urinary 8-Hydroxy-2'-deoxyguanosine in Patients with Diabetes and Hypercholesterolemia"},{"@value":"Probucol and atorvastatin decrease urinary 8-hydroxy-2′-deoxyguanosine in patients with diabetes and hypercholesterolemia"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"To clarify whether probucol and statins suppress oxidative stress in diabetic patients, we studied the effects of probucol and the statin atorvastatin on urinary 8-hydroxy-2’deoxyguanosine (8-OHdG) levels in diabetics with hypercholesterolemia. A randomized, open study was performed on a total of 36 patients with type 2 diabetes and hypercholesterolemia. The patients were randomly assigned to a probucol group (500 mg/day, <I>n</I> = 18) or an atorvastatin group (10 mg/day, <I>n</I> = 18). During three months, total- and LDL-cholesterol decreased significantly in both groups. LDL-cholesterol was significantly lower in the atorvastatin group than probucol group. HDL-C decreased significantly in the probucol group and did not change in the atorvastatin group. 8-OHdG decreased significantly in both groups after 3 months; 12.4 ± 7.5 to 8.1 ± 4.2 ng/mg/Cr in the atorvastatin group (<I>p </I>< 0.05) and 12.3 ± 8.8 to 6.8 ± 2.6 ng/mg/Cr in the probucol group (<I>p </I>< 0.05), and these changes did not differ significantly between the two groups. But, in patients with high 8-OHdG levels (more than 10 ng/mg/Cr) before administration, urinary 8-OHdG decreased significantly from 19.5 ± 4.9 to 9.2 ± 3.4 ng/mg Cr (<I>p </I>< 0.01) in the atorvastatin group, and from 19.7 ± 8.2 to 6.67 ± 2.2 ng/mg Cr (<I>p </I>< 0.01) in the probucol group. Urinary 8-OHdG was significantly lower in the probucol group than in the atorvastatin group after the second and third months of administration (<I>p </I>< 0.05). These results suggest that while probucol and atorvastatin both reduce systemic oxidative stress, probucol might be the more useful in patients with strong oxidative stress."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679407359747","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000391512957"},{"@type":"NRID","@value":"9000000942889"}],"foaf:name":[{"@language":"en","@value":"Koide Nobukiyo"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Center of Diabetes, Endocrinology and Metabolism, Sakura Hospital, Toho University, Chiba, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751135191552","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00398835"},{"@type":"NRID","@value":"1000000398835"},{"@type":"NRID","@value":"9000006191797"},{"@type":"NRID","@value":"9000391512955"},{"@type":"NRID","@value":"9000322101928"},{"@type":"NRID","@value":"9000309999317"},{"@type":"NRID","@value":"9000403158242"},{"@type":"NRID","@value":"9000314381181"},{"@type":"NRID","@value":"9000243892445"},{"@type":"NRID","@value":"9000257808968"},{"@type":"NRID","@value":"9000019074840"},{"@type":"NRID","@value":"9000413895285"},{"@type":"NRID","@value":"9000257808950"},{"@type":"NRID","@value":"9000257808872"},{"@type":"NRID","@value":"9000411567832"},{"@type":"NRID","@value":"9000240051877"},{"@type":"NRID","@value":"9000283343831"},{"@type":"NRID","@value":"9000283343559"},{"@type":"NRID","@value":"9000257811760"},{"@type":"NRID","@value":"9000409789063"},{"@type":"NRID","@value":"9000283595119"},{"@type":"NRID","@value":"9000382675207"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/masahiroohira"}],"foaf:name":[{"@language":"en","@value":"Ohira Masahiro"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Center of Diabetes, Endocrinology and Metabolism, Sakura Hospital, Toho University, Chiba, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679407359744","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000391512954"},{"@type":"NRID","@value":"9000002103091"}],"foaf:name":[{"@language":"en","@value":"Ebisuno Mariko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Center of Diabetes, Endocrinology and Metabolism, Sakura Hospital, Toho University, Chiba, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679407359751","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000391512956"},{"@type":"NRID","@value":"9000001327451"}],"foaf:name":[{"@language":"en","@value":"Saiki Atsuhito"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Center of Diabetes, Endocrinology and Metabolism, Sakura Hospital, Toho University, Chiba, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679407359753","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000391512959"}],"foaf:name":[{"@language":"en","@value":"Takeyoshi Murano"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Clinical Laboratory Medicine, Sakura Hospital, Toho University, Chiba, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679407359746","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000391512958"},{"@type":"NRID","@value":"9000000942893"}],"foaf:name":[{"@language":"en","@value":"Oyama Tomokazu"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Center of Diabetes, Endocrinology and Metabolism, Sakura Hospital, Toho University, Chiba, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679407359750","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000391512951"},{"@type":"NRID","@value":"9000004325500"}],"foaf:name":[{"@language":"en","@value":"Shirai Koji"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Internal Medicine, Sakura Hospital, Toho University, Chiba, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679407359745","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000391512950"},{"@type":"NRID","@value":"9000001693928"}],"foaf:name":[{"@language":"en","@value":"Endo Kei"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Center of Diabetes, Endocrinology and Metabolism, Sakura Hospital, Toho University, Chiba, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679407359749","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000391512952"},{"@type":"NRID","@value":"9000004090924"}],"foaf:name":[{"@language":"en","@value":"Miyashita Yoh"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Center of Diabetes, Endocrinology and Metabolism, Sakura Hospital, Toho University, Chiba, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679407359752","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000391512953"},{"@type":"NRID","@value":"9000001841769"}],"foaf:name":[{"@language":"en","@value":"Sasaki Hidehisa"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Pharmaceutical Department, Sakura Hospital, Toho University, Chiba, Japan."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13403478"},{"@type":"EISSN","@value":"18803873"},{"@type":"NCID","@value":"AA11018976"}],"prism:publicationName":[{"@language":"en","@value":"Journal of Atherosclerosis and Thrombosis"},{"@language":"ja","@value":"Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ"},{"@language":"en","@value":"JAT"},{"@language":"en","@value":"J Atheroscler Thromb"},{"@language":"ja","@value":"Ｊ　Ａｔｈｅｒｏｓｃｌｅｒ　Ｔｈｒｏｍｂ"}],"dc:publisher":[{"@language":"en","@value":"Japan Atherosclerosis Society"},{"@language":"ja","@value":"一般社団法人 日本動脈硬化学会"}],"prism:publicationDate":"2006","prism:volume":"13","prism:number":"1","prism:startingPage":"68","prism:endingPage":"75"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://www.jstage.jst.go.jp/article/jat/13/1/13_1_68/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2007003370"}],"availableAt":"2006","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Probucol","dc:title":"Probucol"},{"@id":"https://cir.nii.ac.jp/all?q=8-OHdG","dc:title":"8-OHdG"},{"@id":"https://cir.nii.ac.jp/all?q=Oxidative%20stress","dc:title":"Oxidative stress"},{"@id":"https://cir.nii.ac.jp/all?q=Diabetes%20mellitus","dc:title":"Diabetes mellitus"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050564285904205440","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Comparison of effects of bezafibrate and fenofibrate on circulating proprotein convertase 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Experimental strategies for optimization of nutritional antioxidant intake in humans"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291225605807744","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291225605813376","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of probucol and pravastatin on common carotid atherosclerosis in patients with asymptomatic hyperlipidemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854175559232512","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Oxidative damage to mitochondrial DNA and its relationship to diabetic complications"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854175559233664","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Prevention 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