Effects of Docosahexaenoic Acid on the Endothelial Function in Patients with Coronary Artery Disease
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- Yagi Shusuke
- Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
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- Aihara Ken-ichi
- Department of Medicine and Bioregulatory Sciences, the University of Tokushima Graduate School of Health Biosciences
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- Fukuda Daiju
- Department of Cardio-Diabetes Medicine, the University of Tokushima Graduate School of Health Biosciences
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- Takashima Akira
- Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
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- Hara Tomoya
- Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
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- Hotchi Junko
- Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
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- Ise Takayuki
- Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
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- Yamaguchi Koji
- Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
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- Tobiume Takeshi
- Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
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- Iwase Takashi
- Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
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- Yamada Hirotsugu
- Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
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- Soeki Takeshi
- Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
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- Wakatsuki Tetsuzo
- Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
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- Shimabukuro Michio
- Department of Cardio-Diabetes Medicine, the University of Tokushima Graduate School of Health Biosciences
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- Akaike Masashi
- Department of Medical Education, the University of Tokushima Graduate School of Health Biosciences
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- Sata Masataka
- Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
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Aim: The consumption of n-3 polyunsaturated fatty acids (PUFA), including docosahexaenoic acid DHA), reduces the incidence of cardiovascular events, and reduced serum levels of n-3 PUFA may be associated with an increased risk of cardiovascular events. However, controversy remains regarding which components of PUFA are associated with the endothelial function in patients with coronary artery disease (CAD). We therefore examined the associations between the n-3 and n-6 PUFA levels and CAD.<br>Methods: We retrospectively reviewed 160 consecutive Japanese patients with CAD whose endothelial function was measured according to the percent change in flow-mediated dilation (FMD) and the serum levels of n-3 PUFA, including eicosapentaenoic acid (EPA) and DHA, and n-6 PUFA, including arachidonic acid (AA) and dihomo-gamma-linolenic acid (DHLA).<br>Results: A single regression analysis showed no relationships between the FMD and the serum levels of PUFA, including EPA, DHA, AA and DHLA. In contrast, a multiple regression analysis showed that the DHA level was a positive (P＜0.01) and age was a negative (P＜0.001) contributor to an increased FMD; however, sex, body mass index, systolic and diastolic blood pressure, current/past smoking and the levels of HbA1c, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, EPA, AA and DHLA did not significantly affect the outcome.<br>Conclusions: The serum level of DHA is associated with the endothelial function evaluated according to the FMD in patients with CAD, thus suggesting that a low serum level of DHA may be a predictive biomarker for endothelial dysfunction.
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ
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Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ 22 (5), 447-454, 2015
一般社団法人 日本動脈硬化学会