{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679432582528.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1539/joh.43.185"}},{"identifier":{"@type":"COI","@value":"1:CAS:528:DC%2BD3MXmsVOntbg%3D"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"5908962"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/5908962"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I5908962"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1539%2Fjoh.43.185"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1539/joh.43.185"}},{"identifier":{"@type":"NAID","@value":"130003416463"}},{"identifier":{"@type":"NAID","@value":"110003723154"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2002070809"}}],"dc:title":[{"@language":"en","@value":"Bisphenol-A Affects Spermatogenesis in the Adult Rat Even at a Low Dose."},{"@value":"Bisphenol‐A Affects Spermatogenesis in the Adult Rat Even at a Low Dose"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"<B>Bisphenol-A Affects Spermatogenesis in the Adult Rat Even at a Low Dose: Motoharu SAKAUE, <I>et al</I>. Environmental Health Sciences Division, National Institute for Environmental Studies</B>—Bisphenol-A (BPA), a xenobiotic estrogenic compound widely used as a plastics monomer, has been suspected to have a so-called low dose effect on the reproductive system when administered transplacentally. In the present study, we investigated possible low-dose effects of BPA on spermatogenesis in adult rats. Male rats (13 weeks old; W13) were administrated a daily oral dose of BPA, ranging from 2 ng to 200 mg/kg, for 6 days and examined for testicular weight (TW) and daily sperm production (DSP) at W14 and W18. A BPA dose as low as 20 μg/kg tended to decrease TW and significantly reduced both DSP and the efficiency of spermatogenesis (DSP per gram testis) at W18, showing that BPA suppressed a normal increase in DSP and TW from W13 to W18. A single administration of 20 μg BPA/kg to W13 rats affected the intensity or mobility of several protein spots in the testicular cytosol fraction as shown by two-dimensional gel electrophoresis analysis. The present study showed that BPA at a low dose affects spermatogenesis in the adult rat. <I>(J Occup Health 2001; 43: 185-190)</I>"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326233752448","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60348589"},{"@type":"NRID","@value":"1000060348589"},{"@type":"NRID","@value":"9000017332851"},{"@type":"NRID","@value":"9000324995776"},{"@type":"NRID","@value":"9000005131455"},{"@type":"NRID","@value":"9000020961548"},{"@type":"NRID","@value":"9000005131231"},{"@type":"NRID","@value":"9000240042769"},{"@type":"NRID","@value":"9000378127193"},{"@type":"NRID","@value":"9000005643665"},{"@type":"NRID","@value":"9000020475483"},{"@type":"NRID","@value":"9000409492508"},{"@type":"NRID","@value":"9000002074871"},{"@type":"NRID","@value":"9000252808522"},{"@type":"NRID","@value":"9000351208114"},{"@type":"NRID","@value":"9000021003593"},{"@type":"NRID","@value":"9000006244906"},{"@type":"NRID","@value":"9000391993334"},{"@type":"NRID","@value":"9000398151019"},{"@type":"NRID","@value":"9000021936923"},{"@type":"NRID","@value":"9000315143038"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/motoharu_sakaue"}],"foaf:name":[{"@language":"en","@value":"SAKAUE 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Health"},{"@language":"ja","@value":"ｊｏｕｒｎａｌ　ｏｆ　Ｏｃｃｕｐａｔｉｏｎａｌ　Ｈｅａｌｔｈ"},{"@language":"en","@value":"J Occup Health"},{"@language":"en","@value":"J. Occup. Health"},{"@language":"ja","@value":"ｊｏｕｒｎａｌ　ｏｆ　Ｏｃｃｕｐａｔｉｏｎａｌ　Ｈｅａｌｔｈ"}],"dc:publisher":[{"@language":"en","@value":"Japan Society for Occupational Health"},{"@language":"ja","@value":"公益社団法人 日本産業衛生学会"}],"prism:publicationDate":"2001","prism:volume":"43","prism:number":"4","prism:startingPage":"185","prism:endingPage":"190"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://id.ndl.go.jp/bib/5908962"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I5908962"},{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1539%2Fjoh.43.185"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1539/joh.43.185"},{"@id":"https://search.jamas.or.jp/link/ui/2002070809"}],"availableAt":"2001","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Bisphenol-A","dc:title":"Bisphenol-A"},{"@id":"https://cir.nii.ac.jp/all?q=Low%20dose","dc:title":"Low dose"},{"@id":"https://cir.nii.ac.jp/all?q=Adult%20rat","dc:title":"Adult rat"},{"@id":"https://cir.nii.ac.jp/all?q=Testis","dc:title":"Testis"},{"@id":"https://cir.nii.ac.jp/all?q=Spermatogenesis","dc:title":"Spermatogenesis"},{"@id":"https://cir.nii.ac.jp/all?q=Daily%20sperm%20production","dc:title":"Daily sperm production"},{"@id":"https://cir.nii.ac.jp/all?q=Testicular%20weight","dc:title":"Testicular weight"},{"@id":"https://cir.nii.ac.jp/all?q=2D-PAGE","dc:title":"2D-PAGE"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011144535742464","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Hemicastration Causes and Testosterone Prevents Enhanced Uptake of [3H] Thymidine by Sertoli Cells in Testes of Immature Rats\n1"}]},{"@id":"https://cir.nii.ac.jp/crid/1360016869030237440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Estrogen Receptor (α and β) Expression in the Excurrent Ducts of the Adult Male Rat Reproductive 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