Synthesis and Antimicrobial Characteristics of Novel Antimicrobial Agent, 1,4-Dialky-1,4-dihydroxyethylpiperadinium Diiodides Immobilized on Inorganic Materials.
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- ZHOU FEI
- Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima
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- MAEDA TAKUYA
- Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima
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- NAGAMUNE HIDEAKI
- Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima
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- KOURAI HIROKI
- Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima
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A series of bis-quaternary ammonium compounds, 1, 4-dialky1-1, 4-dihydroxyethylpiperadinum diiodides (DAHP, bis-QACs), was immobilized on inorganic materials (glass beads and ferrite powder) using trimethoxysilane as a coupler to prepare the immobilized antimicrobial agents. GPA-n [with alkyl chain length (n) of 8 or 12 and a carrier of glass beads] and FPA-n [n =8, 12 and a carrier of ferrite] were developed. Their antimicrobial characteristics against Escherichia coil IFO 3301 or Staphylococcus aureus IFO 12732 were then investigated, and compared with those of [3-(trimethoxysilyl) propyl] octadecyldimethylammonium chloride (TPOAC, mono-QACs) immobilized on inorganic materials. The antibacterial activity of the immobilized DAHP against E. coli IFO 3301 was 30 times higher than that of the immobilized TPOAC. GPA-12 and FPA-12 had a higher antimicrobial activity than GPA-8 and FPA-8, and exhibited wide spectra of antibacterial activity against six strains of gram-negative and five strains of gram-positive bacteria. The antibacterial activity was hardly influenced by environmentalpH but was significantly affected by temperature. A concomitant substance, peptone, had a distinct effect on the antibacterial activity of GPA-12 and FPA-12.
収録刊行物
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- Ｂｉｏｃｏｎｔｒｏｌ Ｓｃｉｅｎｃｅ
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Ｂｉｏｃｏｎｔｒｏｌ Ｓｃｉｅｎｃｅ 8 (4), 167-175, 2003
日本防菌防黴学会
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詳細情報 詳細情報について
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- CRID
- 1390282679441319168
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- NII論文ID
- 10011872178
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- NII書誌ID
- AA11169621
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- ISSN
- 18840205
- 13424815
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可