{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679459507328.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.5650/oleoscience.7.413"}},{"identifier":{"@type":"COI","@value":"1:CAS:528:DC%2BD2sXhtF2rtr7F"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"8954150"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/8954150"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I8954150"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/oleoscience/7/10/7_413/_pdf"}},{"identifier":{"@type":"NAID","@value":"130004650802"}},{"identifier":{"@type":"NAID","@value":"40015656364"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2008069045"}}],"dc:title":[{"@language":"en","@value":"Health and Nutritional Effects of Vitamin E Homologues and Vitamin K"},{"@language":"ja","@value":"ビタミンE類およびビタミンKの健康栄養機能"},{"@language":"ja-Kana","@value":"ビタミン Eルイ オヨビ ビタミン K ノ ケンコウ エイヨウ キノウ"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Vitamin E is the most important and fat-soluble natural anti-oxidant. Since negative correlations between cardiovascular mortality rate and vitamin E intake have been reported, vitamin E supplement continues to be advocated. Although αa-tocopherol has been used as vitamin E, recent studies have demonstrated that γ-tocopherol and tocotrienols, the major homologues of vitamin E of the food origin, have unique health benefits. Thus, usage of γ-tocopherol, tocotrienols, or a combination of natural vitamin E homologue is emphasized, although the effects should be confirmed by large scale clinical tests. Accumulated evidence implicates vitamin K, which was originally recognized as cofactor for blood coagulation, protects against osteoporosis and atherosclerosis. Vitamin K is essential for the optimal action of the calcium-binding-proteins called osteocalcin and matrix Gla protein (MGP). Osteocalcin is essential for bone metabolism, and MGP is known to inhibit calcification in the arteries. Menaquinone-7, a major vitamin K homologue in natto, has the highest nutritional effect."},{"@language":"ja","@value":"ビタミンEは生物界で最も重要な脂溶性の天然抗酸化剤である。心疾患死亡率とビタミンE摂取の問に負の相関があることから, ビタミンEサプリメントが広がってきた。従来ビタミンEとしては最も生理活性の高いα-トコフェロールが使用されてきたが, 食品由来ビタミンE類の重要な成分であるγ-トコフェロールとトコトリエノールに, α-トコフェロールにみられない固有の機能が証明されてきた。これらのビタミンE類の単独摂取や組み合わせ摂取の必要性も推奨されるようになってきているが, 今後, 大規模な臨床試験で効果を確かめることが望まれる。一方, 従来血液凝固の必須因子として知られていたビタミンKが, 骨粗嶺症と動脈硬化を予防することが多くの研究により明らかとなった。ビタミンKはオステオカルシンとマトリックスGlaタンパク質と呼ばれるカルシウム結合性タンパクの活性化に必須である・オステオカルシンは, 骨代謝に必須の働きを示し, マトリックスGlaタンパク質は, 動脈の石灰化を抑制する。ビタミンKのうち, 納豆の主要なビタミンKであるメナキノン-7が最も高い栄養価を有している."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410001205700085504","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000004482549"},{"@type":"NRID","@value":"9000258615464"}],"foaf:name":[{"@language":"en","@value":"SATO Toshiro"},{"@language":"ja","@value":"佐藤 俊郎"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Fine Chemical Laboratory, J-OIL MILLS, INC."},{"@language":"ja","@value":"株式会社J-オイルミルズ ファイン研究所"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13458949"},{"@type":"LISSN","@value":"13458949"},{"@type":"EISSN","@value":"21873461"},{"@type":"NDL_BIB_ID","@value":"000000163126"},{"@type":"ISSN","@value":"13458949"},{"@type":"NCID","@value":"AA11503417"}],"prism:publicationName":[{"@language":"en","@value":"Oleoscience"},{"@value":"オレオサイエンス"}],"dc:publisher":[{"@language":"en","@value":"Japan Oil Chemists' Society"},{"@language":"ja","@value":"公益社団法人 日本油化学会"}],"prism:publicationDate":"2007","prism:volume":"7","prism:number":"10","prism:startingPage":"413","prism:endingPage":"421"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/bib/8954150"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I8954150"},{"@id":"https://www.jstage.jst.go.jp/article/oleoscience/7/10/7_413/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2008069045"}],"availableAt":"2007","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=vitamin%20E","dc:title":"vitamin E"},{"@id":"https://cir.nii.ac.jp/all?q=tocopherol","dc:title":"tocopherol"},{"@id":"https://cir.nii.ac.jp/all?q=%CE%B3-tocopherol","dc:title":"γ-tocopherol"},{"@id":"https://cir.nii.ac.jp/all?q=tocotrienol","dc:title":"tocotrienol"},{"@id":"https://cir.nii.ac.jp/all?q=vitamin%20K","dc:title":"vitamin K"},{"@id":"https://cir.nii.ac.jp/all?q=menaquinone","dc:title":"menaquinone"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011144002204672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The metabolism and distribution of docosapentaenoic acid (n−6) in rats and rat hepatocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145460474752","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tocotrienol: a review of its therapeutic potential"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618889266816","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Evidence for the nitration of γ-tocopherol in vivo: 5-nitro-γ-tocopherol is elevated in the plasma of subjects with coronary heart disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619602091136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lowering of serum cholesterol in hypercholesterolemic 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