{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679473768064.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1248/jhs.53.715"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"9275553"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/9275553"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I9275553"}},{"identifier":{"@type":"URI","@value":"https://dl.ndl.go.jp/pid/8717933"}},{"identifier":{"@type":"URI","@value":"http://www.jstage.jst.go.jp/article/jhs/53/6/53_6_715/_pdf"}},{"identifier":{"@type":"NAID","@value":"110006545938"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2008132413"}}],"dc:title":[{"@language":"en","@value":"Human Aryl Hydrocarbon Receptor Ligand Activity of 31 Non-substituted Polycyclic Aromatic Hydrocarbons as Soil Contaminants"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Toxic equivalency factors (TEFs) of 31 non-substituted polycyclic aromatic hydrocarbons (PAHs) for the human aryl hydrocarbon receptor (AhR) ligand activity were measured using the yeast recombinant reporter gene assay established by Miller <i>et al.</i>, in order to estimate the toxic equivalents of individual PAHs in environmental samples. Ten PAHs showed sigmoid-shape concentration-response curves. An effective concentration to achieve 50% activity obtained with 1 μmol/l benzo[<i>a</i>]pyrene (BaP) (EC<sub>50BaP</sub>) was calculated by curve fitting, and TEFs were calculated from the ratio of EC<sub>50BaP</sub> for BaP to that for the chemical studied. The highest TEF was found for naphthacene (NPC) (TEF=35) followed by benzo[<i>b</i>]fluorene (BbFl) (19), benzo[<i>k</i>]fluoranthene (BkF) (11), benz[<i>a</i>]anthracene (BaA) (7.0), benzo[<i>j</i>]fluoranthene (BjF) (4.0), benzo[<i>a</i>]fluorene (BaFl) (1.9), benzo[<i>b</i>]fluoranthene (BbF) (1.4), chrysene (CHR) (1.1), and BaP (1.0). Concentration dependent activities were also observed for indeno[1,2,3-<i>cd</i>]pyrene (IP) and fluoranthene (FLT). The TEFs of IP and FLT were about 0.2 and 0.02, respectively. The other 19 PAHs, naphthalene (NPT), acenaphtylene (ACL), acenaphthene (ACT), fluorene (FLU), anthracene (ANT), phenanthrene (PHN), pyrene (PYR), triphenylene (TRI), benzo[<i>e</i>]pyrene (BeP), perylene (PER), benzo[<i>ghi</i>]perylene (BgP), dibenz[<i>a, h</i>]anthracene (DahA), picene (PIC), coronene (COR), dibenzo[<i>a, e</i>]pyrene (DaeP), dibenzo[<i>a, h</i>]pyrene (DahP), dibenzo[<i>a, i</i>]pyrene (DaiP), dibenzo[<i>a, l</i>]pyrene (DalP) and naphtho[2,3-<i>a</i>]pyrene (NaP), showed little or no activity in the 0.1-1,000 nmol/l range. The toxic equivalents (TEQs) of surface soil were calculated by multiplication of the TEFs with the concentrations in soil samples collected from Kyoto, Japan. The TEQ of BaA showed the highest value of the 16 US Environmental Protection Agency Priority Pollutant PAHs."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420282801189340928","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70340445"},{"@type":"NRID","@value":"1000070340445"},{"@type":"NRID","@value":"9000254537290"},{"@type":"NRID","@value":"9000004508663"},{"@type":"NRID","@value":"9000003008288"},{"@type":"NRID","@value":"9000356888757"},{"@type":"NRID","@value":"9000009004360"},{"@type":"NRID","@value":"9000005130643"},{"@type":"NRID","@value":"9000020780152"},{"@type":"NRID","@value":"9000023406557"},{"@type":"NRID","@value":"9000287284672"},{"@type":"NRID","@value":"9000004507183"},{"@type":"NRID","@value":"9000415411919"}],"foaf:name":[{"@language":"en","@value":"Murahashi Tsuyoshi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Kyoto Pharmaceutical 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Tetsushi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Kyoto Pharmaceutical University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679473768066","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Kanayama Misa"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Kyoto Pharmaceutical University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679473768064","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000006621713"}],"foaf:name":[{"@language":"en","@value":"Kubo Takako"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Kyoto Pharmaceutical University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679473768067","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Hirayama Teruhisa"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Kyoto Pharmaceutical University"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13449702"},{"@type":"EISSN","@value":"13475207"},{"@type":"CODEN","@value":"JHSCFD"},{"@type":"NDL_BIB_ID","@value":"000000160750"},{"@type":"ISSN","@value":"13449702"},{"@type":"LISSN","@value":"13449702"},{"@type":"NCID","@value":"AA11316464"}],"prism:publicationName":[{"@language":"ja","@value":"ＪＯＵＲＮＡＬ　ＯＦ　ＨＥＡＬＴＨ　ＳＣＩＥＮＣＥ"},{"@language":"en","@value":"Journal of Health Science"},{"@language":"en","@value":"JOURNAL OF HEALTH SCIENCE"},{"@language":"en","@value":"J. Health Sci."},{"@language":"ja","@value":"Ｊ．　Ｈｅａｌｔｈ　Ｓｃｉ．"}],"dc:publisher":[{"@language":"en","@value":"The Pharmaceutical Society of Japan"},{"@language":"ja","@value":"公益社団法人 日本薬学会"}],"prism:publicationDate":"2007","prism:volume":"53","prism:number":"6","prism:startingPage":"715","prism:endingPage":"721"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://id.ndl.go.jp/bib/9275553"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I9275553"},{"@id":"https://dl.ndl.go.jp/pid/8717933"},{"@id":"http://www.jstage.jst.go.jp/article/jhs/53/6/53_6_715/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2008132413"}],"availableAt":"2007","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=aryl%20hydrocarbon%20receptor","dc:title":"aryl hydrocarbon receptor"},{"@id":"https://cir.nii.ac.jp/all?q=polycyclic%20aromatic%20hydrocarbon","dc:title":"polycyclic aromatic hydrocarbon"},{"@id":"https://cir.nii.ac.jp/all?q=soil","dc:title":"soil"},{"@id":"https://cir.nii.ac.jp/all?q=toxic%20equivalency%20factor","dc:title":"toxic equivalency factor"},{"@id":"https://cir.nii.ac.jp/all?q=human","dc:title":"human"},{"@id":"https://cir.nii.ac.jp/all?q=yeast","dc:title":"yeast"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360292620464725376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Human Aryl Hydrocarbon Receptor Signaling Pathway Constructed in Yeast Displays Additive Responses to Ligand Mixtures"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093993056640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The cytosolic receptor binding affinities and ahh induction potencies of 29 polynuclear aromatic hydrocarbons"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568722734976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Characterization of 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Activation of transcription by indole compounds"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980076651613184","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Ability of polycyclic aromatic hydrocarbons to induce 7-ethoxyresorufin-O-deethylase activity in a trout liver cell line"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261551602712704","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Atmospheric washout of polycyclic aromatic hydrocarbons in the southern Chesapeake Bay region"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543024923259904","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Determination of polycyclic aromatic hydrocarbons in bulk precipitation and runoff waters in an urban region (Poland)"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387451541103872","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Polycyclic aromatic hydrocarbons in Brazilian vegetables and fruits"}]},{"@id":"https://cir.nii.ac.jp/crid/1573668926498344576","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Assessment of aryl hydrocarbon receptor complex interactions using pBEVY plasmids : expressionvectors with bi-directional promoters for use in Saccharomyces cerevisiae"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950401408208896","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The cytosolic receptor binding affinities and AHH induction potencies of 29 polynuclear aromatic hydrocarbons"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231874784146176","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Aryl hydrocarbon receptor-mediated activity of mutagenic polycyclic aromatic hydrocarbons determined using in vitro reporter gene assay"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0030308363"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I9275553"},{"@type":"CROSSREF","@value":"10.1248/jhs.53.715"},{"@type":"CIA","@value":"110006545938"},{"@type":"OPENAIRE","@value":"doi_dedup___::26a1948aaa96ab0a779294098b1411e2"}]}