{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679474022656.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1248/jhs.50.75"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"6828454"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/6828454"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I6828454"}},{"identifier":{"@type":"URI","@value":"https://dl.ndl.go.jp/pid/8717465"}},{"identifier":{"@type":"URI","@value":"http://www.jstage.jst.go.jp/article/jhs/50/1/50_1_75/_pdf"}},{"identifier":{"@type":"NAID","@value":"110003609130"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2005098268"}}],"dc:title":[{"@language":"en","@value":"Bioavailability of Zinc Yeast in Rats: Stimulatory Effect on Bone Calcification in Vivo"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"The bioavailability of zinc yeast as a functional food ingredient in rats was investigated. Zinc yeast, zinc sulfate, or zinc oxide was used. Serum zinc concentrations were significantly increased by a single oral administration of zinc yeast, zinc sulfate or zinc oxide at a dose of 10 mg Zn/100 g body weight. A significant increase was observed 1 hr after administration and it was also seen with the lowest dose of Zn 0.5 mg/100 g of zinc yeast or zinc oxide. A single oral administration of zinc yeast, zinc sulfate, or zinc oxide (10 mg Zn/100 g) caused a significant increase in liver zinc content. A significant increase in femoral-diaphyseal and -metaphyseal zinc contents was observed with the administration of zinc yeast or zinc sulfate. When zinc yeast or zinc oxide (10 mg Zn/100 g) was orally administered once daily for 7 days to rats, a significant increase in zinc levels in the serum, liver, and femoral-metaphyseal tissues was seen. Femoral-diaphyseal zinc content was significantly increased with the administration of zinc yeast. A significant increase in calcium content and alkaline phosphatase activity in the femoral-diaphyseal and -metaphyseal tissues occurred with the administration of zinc yeast or zinc oxide. The effect of zinc yeast was greater than that of zinc oxide. This study demonstrated that zinc yeast has high bioavailability in rats, and that its administration induces an anabolic effect on bone calcification <i>in vivo</i>. Zinc yeast may be useful as a functional food ingredient.<br>"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1030003658393669760","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70046308"},{"@type":"NRID","@value":"1000070046308"},{"@type":"NRID","@value":"9000000484955"},{"@type":"NRID","@value":"9000000647027"},{"@type":"NRID","@value":"9000003094672"},{"@type":"NRID","@value":"9000003128210"},{"@type":"NRID","@value":"9000006385424"},{"@type":"NRID","@value":"9000254214793"},{"@type":"NRID","@value":"9000005129696"},{"@type":"NRID","@value":"9000254216128"},{"@type":"NRID","@value":"9000254537501"},{"@type":"NRID","@value":"9000252820283"},{"@type":"NRID","@value":"9000004458007"},{"@type":"NRID","@value":"9000020675509"},{"@type":"NRID","@value":"9000005212416"},{"@type":"NRID","@value":"9000005237277"},{"@type":"NRID","@value":"9000005132873"},{"@type":"NRID","@value":"9000005130841"},{"@type":"NRID","@value":"9000254681513"},{"@type":"NRID","@value":"9000005172742"},{"@type":"NRID","@value":"9000254215542"},{"@type":"NRID","@value":"9000254216696"},{"@type":"NRID","@value":"9000020718278"},{"@type":"NRID","@value":"9000253211350"},{"@type":"NRID","@value":"9000254229961"},{"@type":"NRID","@value":"9000254697587"},{"@type":"NRID","@value":"9000010460291"},{"@type":"NRID","@value":"9000003104450"},{"@type":"NRID","@value":"9000005210926"},{"@type":"NRID","@value":"9000005259696"},{"@type":"NRID","@value":"9000254218290"},{"@type":"NRID","@value":"9000254216714"},{"@type":"NRID","@value":"9000020647634"},{"@type":"NRID","@value":"9000021947462"},{"@type":"NRID","@value":"9000020140855"},{"@type":"NRID","@value":"9000391571100"},{"@type":"NRID","@value":"9000254223487"},{"@type":"NRID","@value":"9000254225340"},{"@type":"NRID","@value":"9000254704549"},{"@type":"NRID","@value":"9000254595917"},{"@type":"NRID","@value":"9000283442291"},{"@type":"NRID","@value":"9000018663089"},{"@type":"NRID","@value":"9000006781317"},{"@type":"NRID","@value":"9000005226947"},{"@type":"NRID","@value":"9000020649032"},{"@type":"NRID","@value":"9000020223097"},{"@type":"NRID","@value":"9000254594074"},{"@type":"NRID","@value":"9000259861072"},{"@type":"NRID","@value":"9000018386284"},{"@type":"NRID","@value":"9000005224338"},{"@type":"NRID","@value":"9000005260283"},{"@type":"NRID","@value":"9000005258750"},{"@type":"NRID","@value":"9000254157190"},{"@type":"NRID","@value":"9000254678303"},{"@type":"NRID","@value":"9000254682899"},{"@type":"NRID","@value":"9000020648773"},{"@type":"NRID","@value":"9000020691717"},{"@type":"NRID","@value":"9000252820752"},{"@type":"NRID","@value":"9000254703380"},{"@type":"NRID","@value":"9000005244653"},{"@type":"NRID","@value":"9000003095220"},{"@type":"NRID","@value":"9000020129518"},{"@type":"NRID","@value":"9000005278086"},{"@type":"NRID","@value":"9000020810148"},{"@type":"NRID","@value":"9000020649967"},{"@type":"NRID","@value":"9000391553680"},{"@type":"NRID","@value":"9000005851511"},{"@type":"NRID","@value":"9000005130793"},{"@type":"NRID","@value":"9000005259898"},{"@type":"NRID","@value":"9000254594524"},{"@type":"NRID","@value":"9000254157097"},{"@type":"NRID","@value":"9000254218311"},{"@type":"NRID","@value":"9000007053717"},{"@type":"NRID","@value":"9000020649652"},{"@type":"NRID","@value":"9000391574100"},{"@type":"NRID","@value":"9000046192002"},{"@type":"NRID","@value":"9000006218777"},{"@type":"NRID","@value":"9000254686810"},{"@type":"NRID","@value":"9000254219676"},{"@type":"NRID","@value":"9000254157273"},{"@type":"NRID","@value":"9000005258606"},{"@type":"NRID","@value":"9000021942840"},{"@type":"NRID","@value":"9000253211562"},{"@type":"NRID","@value":"9000331875985"},{"@type":"NRID","@value":"9000000646964"},{"@type":"NRID","@value":"9000018663081"},{"@type":"NRID","@value":"9000005210852"},{"@type":"NRID","@value":"9000005238964"},{"@type":"NRID","@value":"9000254157791"},{"@type":"NRID","@value":"9000005258933"},{"@type":"NRID","@value":"9000020666107"},{"@type":"NRID","@value":"9000391574687"},{"@type":"NRID","@value":"9000254537301"},{"@type":"NRID","@value":"9000253211889"},{"@type":"NRID","@value":"9000254233354"},{"@type":"NRID","@value":"9000254233256"},{"@type":"NRID","@value":"9000254228107"},{"@type":"NRID","@value":"9000254697609"},{"@type":"NRID","@value":"9000254702831"},{"@type":"NRID","@value":"9000256304018"},{"@type":"NRID","@value":"9000003127889"},{"@type":"NRID","@value":"9000364359572"},{"@type":"NRID","@value":"9000020354711"},{"@type":"NRID","@value":"9000020335357"},{"@type":"NRID","@value":"9000020183240"},{"@type":"NRID","@value":"9000254233885"},{"@type":"NRID","@value":"9000298893846"},{"@type":"NRID","@value":"9000005243137"},{"@type":"NRID","@value":"9000005211124"},{"@type":"NRID","@value":"9000020318157"},{"@type":"NRID","@value":"9000254157257"},{"@type":"NRID","@value":"9000254593096"},{"@type":"NRID","@value":"9000020741085"},{"@type":"NRID","@value":"9000254537436"},{"@type":"NRID","@value":"9000254537180"},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Masayoshi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204497676417","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000005132014"},{"@type":"NRID","@value":"9000254537395"}],"foaf:name":[{"@language":"en","@value":"Igarashi Aki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204498132996","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000005125230"}],"foaf:name":[{"@language":"en","@value":"Uchiyama Satoshi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13449702"},{"@type":"EISSN","@value":"13475207"},{"@type":"CODEN","@value":"JHSCFD"},{"@type":"NDL_BIB_ID","@value":"000000160750"},{"@type":"ISSN","@value":"13449702"},{"@type":"LISSN","@value":"13449702"},{"@type":"NCID","@value":"AA11316464"}],"prism:publicationName":[{"@language":"ja","@value":"ＪＯＵＲＮＡＬ　ＯＦ　ＨＥＡＬＴＨ　ＳＣＩＥＮＣＥ"},{"@language":"en","@value":"Journal of Health Science"},{"@language":"en","@value":"JOURNAL OF HEALTH SCIENCE"},{"@language":"en","@value":"J. Health Sci."},{"@language":"ja","@value":"Ｊ．　Ｈｅａｌｔｈ　Ｓｃｉ．"}],"dc:publisher":[{"@language":"en","@value":"The Pharmaceutical Society of Japan"},{"@language":"ja","@value":"公益社団法人 日本薬学会"}],"prism:publicationDate":"2004","prism:volume":"50","prism:number":"1","prism:startingPage":"75","prism:endingPage":"81"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://id.ndl.go.jp/bib/6828454"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I6828454"},{"@id":"https://dl.ndl.go.jp/pid/8717465"},{"@id":"http://www.jstage.jst.go.jp/article/jhs/50/1/50_1_75/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2005098268"}],"availableAt":"2004","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=zinc","dc:title":"zinc"},{"@id":"https://cir.nii.ac.jp/all?q=zinc%20yeast","dc:title":"zinc yeast"},{"@id":"https://cir.nii.ac.jp/all?q=zinc%20oxide","dc:title":"zinc oxide"},{"@id":"https://cir.nii.ac.jp/all?q=bone","dc:title":"bone"},{"@id":"https://cir.nii.ac.jp/all?q=osteoporosis","dc:title":"osteoporosis"},{"@id":"https://cir.nii.ac.jp/all?q=bioavailability","dc:title":"bioavailability"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011143673774976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Stimulatory effect of ?-alanyl-L-histidinato zinc on cell proliferation is dependent on protein synthesis in osteoblastic MC3T3-E1 cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144440503552","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"The effect of aging on bone formation in rats: Biochemical and histological evidence for decreased bone formation capacity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146642804608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Acid and Alkaline Phosphatase in Serum"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618735834368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Newer Aspects of the Roles of Zinc, Manganese, and Copper in Human Nutrition"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298345425783552","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"β-Aianyi-L-histidinato Zinc: A Potent Activator in Bone Formation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096430032640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role of zinc in bone formation and bone resorption"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569166653696","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Stimulatory effect of daidzein in osteoblastic MC3T3-E1 cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569697157120","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Epidemiology of osteoporosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521399432448","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Inhibitory effect of genistein on osteoclast-like cell formation in mouse marrow cultures"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995297536512","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Calcium and vitamin D enriched diets increase and preserve vertebral mineral content in aging laboratory rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469295207168","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Laboratory diagnosis of zinc deficiency."}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470792593792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of Zinc Deficiency on Serum Somatomedin Levels and Skeletal Growth in Young Rats*"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945533677056","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Stimulatory Effect of Beta-Alanyl-<i>L</i>-Histidinato Zinc on Bone Formation in Tissue Culture"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419546196480","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"β-alanyl-l-histidinato zinc and bone resorption"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420395996672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Aging affects cellular zinc and protein synthesis in the femoral diaphysis of rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895865595008","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369180699648","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Stimulatory effect of zinc on bone formation in tissue culture"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844143651200","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Inhibitory effect of zinc compounds on osteoclast-like cell formation in mouse marrow cultures"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845346094208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Intake of fermented soybean ( natto ) increases circulating vitamin K 2 (menaquinone-7) and γ-carboxylated osteocalcin concentration in normal individuals"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319145501440","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Effect of zinc-chelating dipeptides on osteoblastic MC3T3-E1 cells: Activation of aminoacyl-tRNA synthetase"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795400810752","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of ?-alanyl-L-histidinato zinc on differentiation of osteoblastic MC3T3-El cells: Increases in alkaline phosphatase activity and protein concentration"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269817166848","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Studies on matrix vesicles isolated from chick epiphyseal cartilage Association of pyrophosphatase and ATPase activities with alkaline phosphatase"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204367466880","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Role of Zinc in Bone Metabolism and Preventive Effect on Bone Disorder"},{"@value":"Biomedical research on trace elements award review article: Role of zinc in bone metabolism and preventive effect on bone disorder"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204497676416","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Enhancing Effect of Zinc and Vitamin K2 (Menaquinone-7) on Bone Components in the Femoral Tissue of Female Elderly Rats."}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204498058240","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Wistar-Imamichi Rats Exhibit a Strong Resistance to Cadmium Toxicity."}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204498066688","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Isoflavone and Bone Metabolism: Its Cellular Mechanism and Preventive Role in Bone Loss."}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204621897344","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Histomorphological Confirmation of the Preventive Effect of .BETA.-Alanyl-L-histidinato Zinc on Bone Loss in Ovariectomized Rats."},{"@value":"Histomorphological Confirmation of the Preventive Effect of β-Alanyl-L-Histidinato Zinc on Bone Loss in Ovariectomized Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679473729920","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Prolonged Intake of Dietary Fermented Soybeans (Natto) with the Reinforced Vitamin K2 (Menaquinone-7) Enhances Circulating .GAMMA.-Carboxylated Osteocalcin Concentration in Normal Individuals."}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679473739136","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Preventive Effect of Dietary Fermented Soybean on Bone Loss in Ovariectomized Rats. Enhancement with Isoflavone and Zinc Supplementation."}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679475193728","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Increase in Bone Components of Rats Orally Administered Isoflovone-containing Soybean Extract (Nijiru)"}]},{"@id":"https://cir.nii.ac.jp/crid/1520572360575922560","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Increase in Bone Components of Rats Orally Administered Isoflovone-containing Soybean Extract(Nijiru)"},{"@language":"ja-Kana","@value":"Increase in Bone Components of Rats Orally Administered Isoflovone-containing Soybean Extract Nijiru"}]},{"@id":"https://cir.nii.ac.jp/crid/1523951029610927616","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Prolonged Intake of Dietary Fermented Soybeans(Natto) with the Reinforced Vitamin K2(Menaquinone-7) Enhances Circulating γ-Carboxylated Osteocalcin Concentration in Normal 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