{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679477412480.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.5107/sccj.38.202"}},{"identifier":{"@type":"NAID","@value":"130004188882"}}],"dc:title":[{"@language":"en","@value":"Dermatological Study on Dark Eye Circles and Their Treatment with Newly Developed Cosmetics"},{"@value":"目の周りのくまに対する皮膚科学的検討とその対処法について"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Blood flow stagnation is said to be an important factor for the incidence of dark eye circles, but there are few reports which have studied dark eye circles and the relationship to blood flow. We have examined dark eye circles dermatologically using a non-invasive method and made clear the factor related to it. We have also studied the effect of newly developed cosmetics on improvement of dark eye circles. Melanin and hemoglobin content, hemoglobin oxygen saturation and blood flow rate were measured to compare dark eye circles with a normal control. An increased amount of hemoglobin and decreased hemoglobin oxygen saturation were observed at the site of dark eye circles. We also observed that the blood flow rate was slow at dark eye circles in comparison with cheek. From these results, blood flow stagnation seems to be one of the factors that could induce dark eye circles. In addition, the increase of melanin at dark eye circles was also observed in older subjects. It was considered that not only congestion but also an increase of melanin content in the skin could induce dark eye circles. On the basis of these results, we developed anti-dark eye circle cosmetics that can improve blood circulation, reduce melanin content and maintain high moisture retention in the skin. After three weeks' usage of this product, it was confirmed that dark eye circles were improved, judging from the result of non-invasive instrumental measurements."},{"@value":"美容上問題となる「目の下のくま」の発生要因として, 一般的に血流の停滞が言われているが, 実際にくまと血流の関係について調査した報告は少なく, また, くまについて皮膚生理学的に論じた報告もほとんどない。そこで本研究では, 非侵襲的な方法を用いくまを皮膚科学的に解析し, その要因を明らかにするとともに, その対応を考え, 「目の下のくま」改善効果の高い商品の開発を行った。くまの発生要因を明らかにするために, くまのある女性とない女性を対象に, 眼下部の皮膚メラニン量, ヘモグロビン量およびヘモグロビン酸素飽和度, 血流速度の計測を実施した。くまのある女性の眼下部では, ヘモグロビン量の増加およびヘモグロビン酸素飽和度の減少が観察された。くま部位では頬と比較して血流速度の低下が見られたことから, 上記結果は血流の停滞により引き起こされたと考えられる。またメラニン量の増加も同時に観測され, その傾向は高年齢層でより顕著であった。以上の結果から, くま部位の明度低下は, 血流速度の低下による皮膚毛細血管内の還元ヘモグロビンの増加と, 皮膚メラニン量の増加によるものと考えられた。以上の検討をもとに, くま発生の主要因である「鬱血」および「色素沈着」, くまを目立たせる小じわ, キメの悪化の各々に対処した「血行促進剤」「美白剤」「保湿剤」配合プロトタイプ製剤を処方し, 3週間の連用効果試験を実施した。その結果, 美容技術者による目視評価, 被験者のアンケートにおいてプロトタイプ製剤の, 高いくま改善効果が確認された。また, 機器測定によってもヘモグロビン酸素飽和度の上昇とメラニン量の低下が確認され, 「くま」の改善に本処方は効果的であることが示された。"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410009221326542464","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000256135318"}],"foaf:name":[{"@language":"en","@value":"Masuda Yuji"},{"@language":"ja","@value":"舛田 勇二"}],"jpcoar:affiliationName":[{"@language":"en","@value":"SHISEIDO Research Center"},{"@language":"ja","@value":"株式会社資生堂リサーチセンター"}]},{"@id":"https://cir.nii.ac.jp/crid/1410009221326542469","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000256135319"}],"foaf:name":[{"@language":"en","@value":"Takahashi Motoji"},{"@language":"ja","@value":"高橋 元次"}],"jpcoar:affiliationName":[{"@language":"en","@value":"SHISEIDO Research Center"},{"@language":"ja","@value":"株式会社資生堂リサーチセンター"}]},{"@id":"https://cir.nii.ac.jp/crid/1410009221326542468","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000256135320"}],"foaf:name":[{"@language":"en","@value":"Satou Atsuko"},{"@language":"ja","@value":"佐藤 敦子"}],"jpcoar:affiliationName":[{"@language":"en","@value":"SHISEIDO Research Center"},{"@language":"ja","@value":"株式会社資生堂リサーチセンター"}]},{"@id":"https://cir.nii.ac.jp/crid/1410009221326542472","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000256135321"}],"foaf:name":[{"@language":"en","@value":"Yanai Motohiro"},{"@language":"ja","@value":"矢内 基弘"}],"jpcoar:affiliationName":[{"@language":"en","@value":"SHISEIDO Research Center"},{"@language":"ja","@value":"株式会社資生堂リサーチセンター"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204422114948","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000017340722"}],"foaf:name":[{"@language":"en","@value":"Ochiai Nobuhiko"},{"@language":"ja","@value":"落合 信彦"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"株式会社資生堂リサーチセンター"},{"@language":"en","@value":"SHISEIDO Research Center"}]},{"@id":"https://cir.nii.ac.jp/crid/1410009221326542466","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000256135322"}],"foaf:name":[{"@language":"en","@value":"Yamashita Toyonobu"},{"@language":"ja","@value":"山下 豊信"}],"jpcoar:affiliationName":[{"@language":"en","@value":"SHISEIDO Research Center"},{"@language":"ja","@value":"株式会社資生堂リサーチセンター"}]},{"@id":"https://cir.nii.ac.jp/crid/1410009221326542471","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000256135323"}],"foaf:name":[{"@language":"en","@value":"Iikura Tomio"},{"@language":"ja","@value":"飯倉 登美雄"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"株式会社資生堂リサーチセンター"},{"@language":"en","@value":"SHISEIDO Research Center"}]},{"@id":"https://cir.nii.ac.jp/crid/1410009221326542465","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000256135325"}],"foaf:name":[{"@language":"en","@value":"Ogawa Katsuki"},{"@language":"ja","@value":"小川 克基"}],"jpcoar:affiliationName":[{"@language":"en","@value":"SHISEIDO Research Center"},{"@language":"ja","@value":"株式会社資生堂リサーチセンター"}]},{"@id":"https://cir.nii.ac.jp/crid/1410009221326542467","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000256135326"}],"foaf:name":[{"@language":"en","@value":"Sayama Kazuhiko"},{"@language":"ja","@value":"佐山 和彦"}],"jpcoar:affiliationName":[{"@language":"en","@value":"SHISEIDO Research Center"},{"@language":"ja","@value":"株式会社資生堂リサーチセンター"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03875253"},{"@type":"LISSN","@value":"03875253"},{"@type":"EISSN","@value":"18844146"}],"prism:publicationName":[{"@language":"en","@value":"Journal of Society of Cosmetic Chemists of Japan"},{"@language":"ja","@value":"日本化粧品技術者会誌"},{"@language":"en","@value":"Jouranal of Society Cosmetic Chemists Japan"},{"@language":"ja","@value":"粧技誌"},{"@language":"en","@value":"J. Soc. Cosmet. Chem. Japan"}],"dc:publisher":[{"@language":"en","@value":"The Society of Cosmetic Chemists of Japan"},{"@language":"ja","@value":"日本化粧品技術者会"}],"prism:publicationDate":"2004","prism:volume":"38","prism:number":"3","prism:startingPage":"202","prism:endingPage":"210"},"reviewed":"false","availableAt":"2004","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=dark%20eye%20circles","dc:title":"dark eye circles"},{"@id":"https://cir.nii.ac.jp/all?q=eyelid","dc:title":"eyelid"},{"@id":"https://cir.nii.ac.jp/all?q=blood%20flow","dc:title":"blood flow"},{"@id":"https://cir.nii.ac.jp/all?q=hemoglobin","dc:title":"hemoglobin"},{"@id":"https://cir.nii.ac.jp/all?q=oxygen%20saturation","dc:title":"oxygen saturation"},{"@id":"https://cir.nii.ac.jp/all?q=melanin","dc:title":"melanin"},{"@id":"https://cir.nii.ac.jp/all?q=laser%20Doppler%20flow%20meter","dc:title":"laser Doppler flow meter"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390282680104703872","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Image Analysis and Synthesis of Faces Applied with Make-up Foundation"},{"@value":"4. 化粧顔画像の解析・合成"},{"@language":"ja-Kana","@value":"ケショウ カオ ガゾウ ノ カイセキ ゴウセイ"}]},{"@id":"https://cir.nii.ac.jp/crid/2051714791941817856","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"1B-2 分光顔画像による肌の色素成分イメージングとその応用(特別セッション「コスメティクスと色彩学」,第44回全国大会発表論文集)"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0024329917"},{"@type":"CROSSREF","@value":"10.5107/sccj.38.202"},{"@type":"CIA","@value":"130004188882"},{"@type":"CROSSREF","@value":"10.3169/itej.62.1928_references_DOI_BptWgRtXIXxFQQIMtj3AahdkiHn"}]}